1-Benzyl-5-(4'-n-butylphenyl)-4-methyl-4-imidazolin-2-one | 133260-22-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Benzyl-5-(4'-n-butylphenyl)-4-methyl-4-imidazolin-2-one
• 英文别名: 3-benzyl-4-(4-butylphenyl)-5-methyl-1H-imidazol-2-one
• CAS: 133260-22-7
• 化学式: C₂₁H₂₄N₂O
• 分子量: 320.434
• InChiKey: LQLSODNHCPNHFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 生成 1-Benzyl-5-(4'-n-butylphenyl)-4-methyl-4-imidazolin-2-one
  参考文献：
  名称：

  5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

  摘要：

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.064

文献信息

• 4-imidazoline derivatives
  申请人：Mitsubishi Kasei Corporation

  公开号：US05116858A1

  公开（公告）日：1992-05-26

  4-Imidazoline derivatives represented by the formula (I) and/or formula (II): ##STR1## wherein R.sup.1 represents C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; R.sup.2 and R.sup.3 independently represent hydrogen, C.sub.3 -C.sub.20 alkyl, C.sub.3 -C.sub.20 alkenyl, C.sub.3 -C.sub.20 alkynyl, C.sub.3 -C.sub.20 alkoxy, C.sub.3 -C.sub.20 alkenyloxy, C.sub.3 -C.sub.20 alkynyloxy, C.sub.3 -C.sub.8 cyloalkyl, C.sub.1 -C.sub.10 alkylthio, or optionally substituted aralkyl or aralkyloxy; R.sup.4 represents C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; provided that R.sup.2 and R.sup.3 cannot be hydrogen at the same time, and pharmaceutically acceptable salts thereof. A pharmaceutical formulation containing the compound is also provided.

  4-咪唑啉衍生物的化学式(I)和/或化学式(II)：其中R.sup.1代表C.sub.1 -C.sub.8烷基，C.sub.3 -C.sub.8烯基，C.sub.3 -C.sub.8炔基，C.sub.3 -C.sub.8环烷基，或者可选择地取代的芳基烷基；R.sup.2和R.sup.3独立地代表氢，C.sub.3 -C.sub.20烷基，C.sub.3 -C.sub.20烯基，C.sub.3 -C.sub.20炔基，C.sub.3 -C.sub.20烷氧基，C.sub.3 -C.sub.20烯氧基，C.sub.3 -C.sub.20炔氧基，C.sub.3 -C.sub.8环烷基，C.sub.1 -C.sub.10硫代烷基，或者可选择地取代的芳基烷基或芳基烷氧基；R.sup.4代表C.sub.1 -C.sub.6烷基，C.sub.3 -C.sub.8环烷基，或者可选择地取代的芳基烷基；但要求R.sup.2和R.sup.3不能同时为氢，以及其药学上可接受的盐。还提供了含有该化合物的药物配方。
• 4-Imidazoline derivatives and their use in preparing pharmaceutical compositions
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0396973A1

  公开（公告）日：1990-11-14

  4-lmidazoline derivatives represented by the formula (I) and/or formula (II): wherein R1 represents C1-C8 alkyl, C3-C8 alkenyl, C3-Cs alkynyl, C3-C8 cycloalkyl, or optionally substituted aralkyl; R2 and R3 independently represent hydrogen, C3-C20 alkyl, C3-C20 alkenyl, C3-C20 alkynyl, C3-C20 alkoxy, C3-C20 alkenyloxy, C3-C20 alkynyloxy, C3-CS cycloalkyl, C1-C10 alkylthio, or optionally substituted aralkyl or aralkyloxy; R4 represents C1-C6 alkyl, C3-C8 cycloalkyl, or optionally substituted aralkyl; provided that R2 and R3 cannot be hydrogen at the same time, and pharmaceutically acceptable salts thereof. A pharmaceutical formulation containing the compound is also provided.

  由式 (I) 和/或式 (II) 代表的 4-咪唑啉衍生物： 其中 R1 代表 C1-C8 烷基、C3-C8 烯基、C3-Cs 炔基、C3-C8 环烷基或任选取代的芳烷基；R2 和 R3 独立地代表氢、C3-C20 烷基、C3-C20 烯基、C3-C20 炔基、C3-C20 烷氧基、C3-C20 烯氧基、C3-C20 炔氧基、C3-CS 环烷基、C1-C10 硫代烷基或任选取代的芳烷基或芳烷氧基； R4 代表 C1-C6 烷基、C3-C8 环烷基或任选取代的芳烷基；但 R2 和 R3 不能同时为氢，以及其药学上可接受的盐。 还提供了含有该化合物的药物制剂。
• US5116858A
  申请人：——

  公开号：US5116858A

  公开（公告）日：1992-05-26
• 5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
  作者：Kazutoshi Watanabe、Yasuhiro Morinaka、Yoshio Hayashi、Masaki Shinoda、Hiroyoshi Nishi、Nobuko Fukushima、Toshiaki Watanabe、Akira Ishibashi、Satoshi Yuki、Masahiko Tanaka

  DOI：10.1016/j.bmcl.2007.12.064

  日期：2008.2

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.