p-(methylthio)phenethyl bromide | 613233-75-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: p-(methylthio)phenethyl bromide
• 英文别名: 1-(2-bromoethyl)-4-methylsulfanylbenzene；(+/-)-4-methylthiophenethyl bromide；4-methylthiophenethyl bromide
• CAS: 613233-75-3
• 化学式: C₉H₁₁BrS
• 分子量: 231.156
• InChiKey: YUGWUZOHOJMMHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  p-(methylthio)phenethyl bromide 在 偶氮二异丁腈 、 三正丁基氢锡 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 苯 为溶剂， 反应 25.0h， 生成 (+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methanesulfonylphenyl)propyl)-12H-pyrano-[4,3j]-1,2-benzodioxepin-10(3H)-one
  参考文献：
  名称：

  Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies toward the Development of Artemisinin-Based Drugs against Leishmaniasis and Malaria

  摘要：

  Artemisinin (1) and its analogues have been well studied for their antimalarial activity. Here we present the antimalarial activity of some novel C-9-modified artemisinin analogues synthesized using artemisitene as the key intermediate. Further, antileishmanial activity of more than 70 artemisinin derivatives against Leishmania donovani promastigotes is described for the first time. A comprehensive structure-activity relationship study using CoMFA is discussed. These analogues exhibited leishmanicidal activity in micromolar concentrations, and the overall activity profile appears to be similar to that against malaria. Substitution at the C-9beta position was shown to improve the activity in both cases. The 10-deoxo derivatives showed better activity compared to the corresponding lactones. In general, compounds with C-9alpha substitution exhibited lower antimalarial as well as antileishmanial activities compared to the corresponding C-9beta analogues. The importance of the peroxide group for the observed activity of these analogues against leishmania was evident from the fact that 1-deoxyartemisinin analogues did not exhibit antileishmanial activity. The study suggests the possibility of developing artemisinin analogues as potential drug candidates against both malaria and leishmaniasis.

  DOI：

  10.1021/jm030181q
• 作为产物：
  描述：

  2-[4-(methylmercapto)phenyl]-1-ethanol 在 咪唑 、 溴 、 三苯基膦 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 2.0h， 以92%的产率得到p-(methylthio)phenethyl bromide
  参考文献：
  名称：

  [EN] ARTEMISININ-BASED PEROXIDE COMPOUNDS AS BROAD SPECTRUM ANTI-INFECTIVE AGENTS
  [FR] COMPOSES DE PEROXYDE A BASE D'ARTEMISININE TENANT LIEU D'AGENTS ANTI-INFECTIEUX A LARGE SPECTRE

  摘要：

  本文描述了合成、生物测定结果以及新的C-9和C-10取代青蒿素衍生物的用途，这些衍生物具有易于功能化的基团，通过碳链或杂原子连接到青蒿素骨架上。同时还展示了这类化合物在广谱抗寄生虫活性方面的表现。其中一些类似物具有明显的细胞毒性，专门用于治疗癌症性疾病。

  公开号：

  WO2003095444A1

文献信息

• Thermodynamic Stabilities of Phenonium Ions Based on Bromide-Transfer Equilibria in the Gas Phase
  作者：Mustanir、Masaaki Mishima、Mizue Fujio、Yuho Tsuno

  DOI：10.1246/bcsj.71.1401

  日期：1998.6

  α-cumyl(1-methyl-1-phenylethyl) cation suggested that π-delocalization in the phenonium ion is essentially less effective than through a benzylic π-interaction. On the other hand, the ρ value of −12.6 is distinctly larger than that for the ordinary benzylic carbocation systems, but is comparable to that of the benzenium ion. In addition, it has been found that the r+ value of the phenonium ions in the gas phase

  苯鎓（亚乙基苯鎓）离子和环取代衍生物的热力学稳定性是基于气相中的溴化物转移平衡确定的。已经表明，苯鎓离子比叔丁基阳离子稳定 2.4 kcal mol-1，并且取代基对其稳定性的影响可以与具有 -12.6 的 ρ 值和 r+ 的 Yukawa-Tsuno 方程相关联0.62。r+ 值小于 α-枯基（1-甲基-1-苯乙基）阳离子的单位值表明，苯鎓离子中的 π-离域作用基本上不如通过苄基 π-相互作用有效。另一方面，-12.6 的 ρ 值明显大于普通苄型碳正离子系统的值，但与苯离子相当。此外，已经发现，气相中苯鎓离子的 r+ 值与芳基辅助过程中 2-芳基乙基甲苯磺酸酯的乙酰化过程中的 r+ 值完全一致。这表明 π 的度数...
• CYCLIC TERTIARY AMINE COMPOUND
  申请人：Sankyo Company, Limited

  公开号：EP1632488A1

  公开（公告）日：2006-03-08

  The present invention provides a cyclic tertiary amine compound which is capable of inhibiting the production of inflammatory cytokines. It is either a compound having a structure represented by the following general formula (I): (wherein A represents an optionally substituted trivalent group derived from pyrimidine, pyrrole, or the like; R1 represents an aryl or a heteroaryl group which may optionally be substituted; R2 represents a heteroaryl group which may optionally be substituted; and R3 represents a cyclic tertiary amino group) or a pharmacologically acceptable salt of the compound.

  本发明提供了一种能够抑制炎症细胞因子产生的环状三级胺化合物。它是具有以下一般式(I)所表示结构的化合物：（其中A表示从嘧啶、吡咯等衍生的可选择取代的三价基团；R1表示可能被取代的芳基或杂环芳基团；R2表示可能被取代的杂环芳基团；R3表示环状三级胺基团），或该化合物的药理学可接受的盐。
• Artemisinin-based peroxide compounds as broad spectrum anti-infective agents
  申请人：Avery Mitchell

  公开号：US20050240034A1

  公开（公告）日：2005-10-27

  Described herein is the synthesis, bioassay results and utility of new C- 9 and C- 10 substituted artemisinin derivatives with easily functionalizable groups attached to the artemisinin skeleton through carbon chain or heteroatoms. Described also is the demonstration of this class of compounds for their broad-spectrum anti-parasitic activity. Certain of these analogs possess noticeable cytotoxicity deliberately focused on treatment of cancerous diseases.

  本文介绍了一种新型C-9和C-10取代青蒿素衍生物的合成、生物测定结果和实用性，这些衍生物通过碳链或杂原子与青蒿素骨架连接，具有易于官能团化的基团。同时，本文还展示了这类化合物的广谱抗寄生虫活性。其中某些类似物具有明显的细胞毒性，可用于治疗癌症疾病。
• CPCR Agonists
  申请人：Bradly Stuart Edward

  公开号：US20100063081A1

  公开（公告）日：2010-03-11

  Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

  式(I)的化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
• Cyclic tertiary amine compound
  申请人：Kimura Tomio

  公开号：US20070049620A1

  公开（公告）日：2007-03-01

  A cyclic tertiary amine compound which is capable of inhibiting the production of inflammatory cytoines. The compound having a structure represented by the following formula (I): wherein A represents an optionally substituted trivalent group which is benzene, pyrimidine, pyrrole, pyridine, pyridazine, furan, thiopene, pyrazole, imidazole, isoxazole or isothiazole; R 1 represents an aryl or a heteroaryl group, which is unsubstituted or substituted; R 2 represents a heteroaryl group which is unsubtituted or substituted; and R 3 represents a cyclic tertiary amino group, or a pharmacologically acceptable salt of the compound.

  一种环状三级胺化合物，能够抑制炎症细胞因子的产生。该化合物具有以下式子（I）所表示的结构：其中A代表苯、嘧啶、吡咯、吡啶、吡嗪、呋喃、噻吩、吡唑、咪唑、异恶唑或异硫唑的可选取代三价基团；R1代表非取代或取代的芳基或杂环基团；R2代表非取代或取代的杂环基团；R3代表环状三级胺基团，或该化合物的药理学上可接受的盐。