(S)-8-amino-3-[2,3-bis(tert-butyldimethylsilyloxy)propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine | 1187577-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: (S)-8-amino-3-[2,3-bis(tert-butyldimethylsilyloxy)propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine
• 英文别名: 4-[(2S)-2,3-bis[[tert-butyl(dimethyl)silyl]oxy]propyl]-2,4,6,11,13-pentazatricyclo[7.4.0.03,7]trideca-1,3(7),5,8,10,12-hexaen-10-amine
• CAS: 1187577-41-8
• 化学式: C₂₃H₄₀N₆O₂Si₂
• 分子量: 488.781
• InChiKey: HGKLVMQAOMESFA-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.37
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (S)-8-amino-3-[2,3-bis(tert-butyldimethylsilyloxy)propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine 在 吡啶 、 四丁基氟化铵 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 14.5h， 生成 8-benzoylamino-3-[(2S)-3-(4,4'-dimethoxytrityloxy)-2-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxy]-propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine
  参考文献：
  名称：

  Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms

  摘要：

  The development of a reliable and simple method for detecting single nucleotide polymorphisms (SNPs), common genetic variations in the human genome, is currently an important research area because SNPs are important for identifying disease-causing genes and for pharmacogenetic studies. Here, we developed a novel method for SNP detection. We designed and synthesized DNA probes containing a fluorescent tricyclic base-linked acyclonucleoside P. The type of nucleobases involved in the SNP sites in the DNA and RNA targets could be determined using four DNA probes containing P. Thus, this system would provide a novel and simple method for detecting SNPs in DNA and RNA targets. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.045
• 作为产物：
  描述：

  (9ci)-5-氨基-1H-咪唑并[4,5-b]吡啶-6-甲腈 在 咪唑 、 potassium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 169.0h， 生成 (S)-8-amino-3-[2,3-bis(tert-butyldimethylsilyloxy)propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine
  参考文献：
  名称：

  Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms

  摘要：

  The development of a reliable and simple method for detecting single nucleotide polymorphisms (SNPs), common genetic variations in the human genome, is currently an important research area because SNPs are important for identifying disease-causing genes and for pharmacogenetic studies. Here, we developed a novel method for SNP detection. We designed and synthesized DNA probes containing a fluorescent tricyclic base-linked acyclonucleoside P. The type of nucleobases involved in the SNP sites in the DNA and RNA targets could be determined using four DNA probes containing P. Thus, this system would provide a novel and simple method for detecting SNPs in DNA and RNA targets. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.045

文献信息

• Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms
  作者：Kinji Furukawa、Mayumi Hattori、Tokimitsu Ohki、Yoshiaki Kitamura、Yukio Kitade、Yoshihito Ueno

  DOI：10.1016/j.bmc.2011.11.045

  日期：2012.1

  The development of a reliable and simple method for detecting single nucleotide polymorphisms (SNPs), common genetic variations in the human genome, is currently an important research area because SNPs are important for identifying disease-causing genes and for pharmacogenetic studies. Here, we developed a novel method for SNP detection. We designed and synthesized DNA probes containing a fluorescent tricyclic base-linked acyclonucleoside P. The type of nucleobases involved in the SNP sites in the DNA and RNA targets could be determined using four DNA probes containing P. Thus, this system would provide a novel and simple method for detecting SNPs in DNA and RNA targets. (C) 2011 Elsevier Ltd. All rights reserved.