Thiophen-2-thiohydroxamsaeure

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: Thiophen-2-thiohydroxamsaeure
• 英文别名: N-hydroxythiophene-2-carbothioamide
• 化学式: C₅H₅NOS₂
• 分子量: 159.233
• InChiKey: BSRAWLJOZCGGFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-溴-3-甲基-2-丁烯 、 五氟苯甲酰氯 、 Thiophen-2-thiohydroxamsaeure 在 四丁基碘化铵 、 三乙胺 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以47%的产率得到3-methylbut-2-en-1-yl N-((perfluorobenzoyl)oxy)thiophene-2-carbimidothioate
  参考文献：
  名称：

  Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives

  摘要：

  An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydroximic acids that serve as potentially useful building blocks for organic synthesis.

  DOI：

  10.1021/jo500080x
• 作为产物：
  描述：

  噻酚-2-甲醛肟 在 sodium sulfide 、 N-氯代丁二酰亚胺 、 三乙胺 作用下， 以 乙醚 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 Thiophen-2-thiohydroxamsaeure
  参考文献：
  名称：

  Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives

  摘要：

  An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydroximic acids that serve as potentially useful building blocks for organic synthesis.

  DOI：

  10.1021/jo500080x

文献信息

• Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives
  作者：Bérénice C. Lemercier、Joshua G. Pierce

  DOI：10.1021/jo500080x

  日期：2014.3.7

  An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydroximic acids that serve as potentially useful building blocks for organic synthesis.