N-nonyl-valeric acid amide | 114084-61-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-nonyl-valeric acid amide
• 英文别名: N-nonylpentanamide
• CAS: 114084-61-6
• 化学式: C₁₄H₂₉NO
• 分子量: 227.39
• InChiKey: GOMQAPPROMGMME-UHFFFAOYSA-N

物化性质

• 熔点：
  29-31 °C
• 沸点：
  304.6±10.0 °C(Predicted)
• 密度：
  0.856±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-nonyl-valeric acid amide 、 氢化铝锂 生成 N-pentylnonan-1-amine
  参考文献：
  名称：

  GALL, RUDI;BOSIES, ELMAR

  摘要：

  DOI：
• 作为产物：
  描述：

  壬胺 、 戊酰氯 以 乙醚 为溶剂， 生成 N-nonyl-valeric acid amide
  参考文献：
  名称：

  Diphosphonate derivatives, pharmaceutical compositions and methods of use

  摘要：

  本发明提供了一般式为：##STR1## 的二膦酸盐，其中R.sub.1是直链或支链，饱和或不饱和的1-9个碳原子的脂肪烃基，可选地被苯或环己基取代，R.sub.2是环己基或环己基甲基、苄基或4到18个碳原子的直链或支链、饱和或不饱和的脂肪烃，可选地被苯或氧取代，其中氧可以被酯化或乙醚化，R.sub.3是氢或1-4个碳原子的直链或支链烷基，X是1-6个碳原子的直链或支链烷基，Y是氢、羟基或氨基，可选地被1-6个碳原子的烷基取代；以及其药学上可接受的盐。本发明还提供了制备这些二膦酸衍生物的方法和含有它们的药物组合物，用于预防和治疗钙代谢疾病或紊乱，如骨质疏松症、帕吉特病、贝克特瑞氏病、骨转移、尿路结石、异位骨化、类风湿性关节炎、骨关节炎和退行性关节炎。

  公开号：

  US04927814A1

文献信息

• MODULATION OF THE IMMUNE RESPONSE
  申请人：Nguyen David-Huy Nhu

  公开号：US20120009222A1

  公开（公告）日：2012-01-12

  The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
• [EN] COMPOSITION AND DEVICE FOR FACILITATING VENIPUNCTURE<br/>[FR] COMPOSITION ET DISPOSITIF POUR FACILITER UNE PONCTION VEINEUSE
  申请人：MEDIS S R L

  公开号：WO2005051365A1

  公开（公告）日：2005-06-09

  A device for external use designed to improve the location of subcutaneous veins so as to facilitate the practice of venipuncture, which said device is based on substances able to highlight the venous system without damaging the skin application area.
• [EN] MODULATION OF THE IMMUNE RESPONSE<br/>[FR] MODULATION DE LA RÉPONSE IMMUNITAIRE
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2010062322A2

  公开（公告）日：2010-06-03

  The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceutical compositions thereof and methods for using the same.