Phosphine‐ and Hydrogen‐Free: Highly Regioselective Ruthenium‐Catalyzed Hydroaminomethylation of Olefins
作者:Samet Gülak、Lipeng Wu、Qiang Liu、Robert Franke、Ralf Jackstell、Matthias Beller
DOI:10.1002/anie.201402368
日期:2014.7.7
A highly regioselective ruthenium‐catalyzed hydroaminomethylation of olefins is reported. Using easily available trirutheniumdodecacarbonyl an efficient sequence consisting of a water‐gas shift reaction, hydroformylation of olefins, with subsequent imine or enamine formation and final reduction is realized. This novel procedure is highly practical (ligand‐free, one pot) and economic (low catalyst loading
据报道,烯烃具有高度区域选择性的钌催化的氢氨基甲基化作用。使用容易获得的十二烷基三羰基羰基化合物,可以实现由水煤气变换反应,烯烃的加氢甲酰化,随后的亚胺或烯胺形成以及最终的还原反应组成的有效序列。这种新颖的方法非常实用(无配体,一锅),经济(催化剂用量低,金属价格便宜)。本体工业的以及官能化的烯烃与各种胺反应,通常以高收率(高达92%),优异的区域选择性(n / iso > 99:1)和对终端烯烃有利的全化学选择性,得到相应的叔胺。