2-氯-3-硝基苯磺酰氯 | 15945-25-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-3-硝基苯磺酰氯
• 英文名称: 2-chloro-3-nitrobenzenesulfonyl chloride
• 英文别名: 2-Chlor-3-nitrobenzolsulfonylchlorid；chloro-nitro-benzenesulphonyl chloride
• CAS: 15945-25-2
• 化学式: C₆H₃Cl₂NO₄S
• 分子量: 256.066
• InChiKey: XVHPRYPYHDUEAH-UHFFFAOYSA-N

物化性质

• 熔点：
  76-78 °C
• 沸点：
  374.6±32.0 °C(Predicted)
• 密度：
  1.708±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氯-3-硝基苯磺酰氯 在 氢碘酸 作用下， 反应 3.0h， 以87%的产率得到bis(2-chloro-3-nitrophenyl)disulfide
  参考文献：
  名称：

  Preparation and NMR Analysis of 2,6-Heterodifunctional Halobenzenes as Precursors for Substituted Biphenyls

  摘要：

  Preparation and complete characterization of 16 2,6-disubstituted halobenzenes, including nine new compounds, from two common starting materials is described. Seven of the new compounds contain one or two propylthio groups, which have been introduced in two ways. Direct reaction of arenediazonium salts with 1-propanethiolate gives yields comparable to those obtained in a three-step method through sulfonyl chlorides. The H-1- and C-13 NMR chemical shifts of 17 1,2,3-trisubstituted benzenes have been correlated with the predicted values and the observed trends explained using commonly available modeling packages. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)01019-4
• 作为产物：
  描述：

  2,6-二硝基氯苯 在 盐酸 、 铁粉 、 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 3.5h， 生成 2-氯-3-硝基苯磺酰氯
  参考文献：
  名称：

  Preparation and NMR Analysis of 2,6-Heterodifunctional Halobenzenes as Precursors for Substituted Biphenyls

  摘要：

  Preparation and complete characterization of 16 2,6-disubstituted halobenzenes, including nine new compounds, from two common starting materials is described. Seven of the new compounds contain one or two propylthio groups, which have been introduced in two ways. Direct reaction of arenediazonium salts with 1-propanethiolate gives yields comparable to those obtained in a three-step method through sulfonyl chlorides. The H-1- and C-13 NMR chemical shifts of 17 1,2,3-trisubstituted benzenes have been correlated with the predicted values and the observed trends explained using commonly available modeling packages. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)01019-4

文献信息

• ANTICOAGULANT COMPOUNDS, PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS TO TREAT THROMBOTIC CONDITIONS, AND PLASMA-SUBSTITUTING SOLUTION TO CORRECT HYPERCOAGULATION DEFECTS OF HEMODILUTION
  申请人：Sinauridze Elena Ivanovna

  公开号：US20110003826A1

  公开（公告）日：2011-01-06

  This invention relates to new chemical compounds, application of these compounds as anticoagulants, pharmaceutical compositions, and plasma-substituting solutions on their basis, and can be used for treating thromboembolic complications of diseases such as myocardial infarction, stroke, and thrombosis of deep veins or a pulmonary artery; and for preventing hypercoagulation conditions in consequence of injuries, surgeries, sepsis, various obstetric pathologies, in disaster medicine, resuscitation, and so on.

  这项发明涉及新的化合物、这些化合物作为抗凝血剂的应用、基于这些化合物的药物组合以及代用血浆溶液，并可用于治疗心肌梗死、中风、深静脉或肺动脉血栓形成等疾病的血栓栓塞并预防因受伤、手术、败血症、各种产科病理等原因导致的高凝血状态，在灾难医学、复苏等方面也可应用。
• THROMBIN FUNCTION COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEM
  申请人：Sinauridze Elena Ivanovna

  公开号：US20100324058A1

  公开（公告）日：2010-12-23

  This invention relates to new chemical compounds, application of these compound as thrombin inhibitors, and pharmaceutical compositions based on them, and can be used to treat and prevent thrombin-dependent thromboembolic events, and in research.

  这项发明涉及新的化合物，这些化合物作为凝血酶抑制剂的应用，以及基于它们的药物组合物，可用于治疗和预防依赖凝血酶的血栓栓塞事件，并用于研究。
• Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles
  申请人：Pfizer Inc.

  公开号：US04002623A1

  公开（公告）日：1977-01-11

  1-[3-(Dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)propyl]imidazo[4,5-b]pyridines and salts thereof with pharmaceutically acceptable acids, a novel class of compounds useful in the treatment of inflammatory conditions. Alternate methods of preparation are provided and the primary synthetic route is described in detail.

  1-[3-(二烷基氨基)丙基]-2-酰胺基苯并咪唑和2-酰胺基氨基-3-[3-(二烷基氨基)丙基]咪唑并[4,5-b]吡啶以及它们与药用可接受的酸盐，是一类新型化合物，在治疗炎症性疾病中有用。提供了替代制备方法，并详细描述了主要的合成途径。
• [EN] SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY<br/>[FR] SULFONAMIDES AYANT UNE ACTIVITE ANTI-ANGIOGENIQUE ET ANTICANCEREUSE
  申请人：ABBOTT LAB

  公开号：WO2004033419A1

  公开（公告）日：2004-04-22

  Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

  描述了具有甲硫氨酸氨肽酶-2（MetAP2）抑制剂的化合物。还描述了包含这些化合物的制药组合物，使用这些化合物进行治疗的方法，抑制血管生成的方法以及治疗癌症的方法。
• Silver halide photographic materials with reducible brightening agent
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04942114A1

  公开（公告）日：1990-07-17

  A silver halide photographic material having at least one silver halide emulsion layer on a support, comprising a compound of formula (I): PWR--(Time).sub.t --FWA (I) in which PWR represents a group capable of releasing (Time).sub.t --FWA upon reduction; FWA represents a group which functions as a brightening agent; Time represents a group capable of releasing FWA through a reaction which follows the release of (Time).sub.t --FWA from PWR; and t represents an integer of 0 or 1.

  一种银卤化物感光材料，其在支撑体上具有至少一层银卤化物乳胶层，包括式(I)的化合物：PWR--(Time).sub.t --FWA(I)，其中PWR代表能够在还原时释放(Time).sub.t --FWA的基团；FWA代表作为增白剂的基团；Time代表通过在释放PWR中的(Time).sub.t --FWA后发生的反应来释放FWA的基团；t表示0或1的整数。