(S)-(+)-methyl 6-methyl-4-phenyl-1,4-dihydropyridazine-5-carboxylate | 1233823-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-(+)-methyl 6-methyl-4-phenyl-1,4-dihydropyridazine-5-carboxylate
• CAS: 1233823-73-8
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: ZZHKFPPFAQOCNB-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  50.69
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-aminocarbonyl-3-methyl-4-methoxycarbonyl-1,2-diaza-1,3-diene 、 苯乙醛 在 (S)-(pyrrolidinemethyl)pyrrolidine 、 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 生成 (R)-(-)-methyl 6-methyl-4-phenyl-1,4-dihydropyridazine-5-carboxylate 、 (S)-(+)-methyl 6-methyl-4-phenyl-1,4-dihydropyridazine-5-carboxylate
  参考文献：
  名称：

  Organocatalyzed synthesis of chiral non-racemic 1,4-dihydropyridazines

  摘要：

  Chiral non-racemic 1,4-dihydropyridazines were prepared by the reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes under organocatalytic conditions. L-Proline and (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine coupled with trifluoroacetic acid were used as organocatalysts. Enantiomeric excesses ranged from 25% to 78%. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.03.007

文献信息

• Organocatalyzed synthesis of chiral non-racemic 1,4-dihydropyridazines
  作者：Giuliana Pitacco、Orazio A. Attanasi、Lucia De Crescentini、Gianfranco Favi、Fulvia Felluga、Cristina Forzato、Fabio Mantellini、Patrizia Nitti、Ennio Valentin、Ennio Zangrando

  DOI：10.1016/j.tetasy.2010.03.007

  日期：2010.3

  Chiral non-racemic 1,4-dihydropyridazines were prepared by the reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes under organocatalytic conditions. L-Proline and (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine coupled with trifluoroacetic acid were used as organocatalysts. Enantiomeric excesses ranged from 25% to 78%. (C) 2010 Elsevier Ltd. All rights reserved.