环酰菌胺 | 126833-17-8

• 物质功能分类: 化学农药原药 - 杀菌剂 - 其他杀菌剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 环酰菌胺
• 中文别名: N-(2,3-二氯-4-羟基苯基)-1-甲基环己甲酰胺；N-(2,3-二氯-4-羟基苯基)-1-甲基环己烷甲酰胺
• 英文名称: fenhexamid
• 英文别名: N-(2,3-dichloro-4-hydroxy-phenyl)-1-methyl-cyclohexanecarboxamide；N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexane-1-carboxamide；N-(2,3-dichloro-4-hydroxyphenyl)-1-methyl-cyclohexanecarboxamide；N-(2,3-dichloro-4-hydroxyphenyl)-1-methyl-cyclohexyl carboxamide；N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide；N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexylcarboxamide
• CAS: 126833-17-8
• 化学式: C₁₄H₁₇Cl₂NO₂
• 分子量: 302.2
• InChiKey: VDLGAVXLJYLFDH-UHFFFAOYSA-N

物化性质

• 熔点：
  141°
• 沸点：
  320°C(lit.)
• 密度：
  1.338±0.06 g/cm3(Predicted)
• 闪点：
  150 °C
• 溶解度：
  DMF：5 mg/ml，DMSO：3 mg/ml，乙醇：微溶
• LogP：
  4.020 (est)
• 颜色/状态：
  White powder
• 蒸汽压力：
  3X10-9 mm Hg at 20 °C /Extrapolated/
• 稳定性/保质期：
  Stable to hydrolysis for 30 days at pH 5, 7, 9 (25 °C).
• 分解：
  When heated to decomposition it emits toxic vapors of nitrogen oxides and chloride.
• 解离常数：
  pKa = 7.3
• 碰撞截面：
  164.82 Ų [M+H]+ [CCS Type: TW]

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

ADMET

代谢

迅速且完全吸收/排泄（<48小时）在大鼠中；明显的肠肝循环。胆汁中的代谢物-葡萄糖苷酸；主要排泄途径/粪便（大部分为原形）；尿液中较少（大部分为葡萄糖苷酸）。

Rapidly and completely absorbed/excreted (<48 hours) /in rats/; pronounced enterohepatic circulation. Metabolite in bile- glucuronide; major route of excretion/feces (mostly parent); lesser amounts in urine (mostly glucuronide).

来源:Hazardous Substances Data Bank (HSDB)

代谢

在大鼠中的代谢物表征研究表明，在排泄物中检测到的主要成分是未改变的母化合物，占给药剂量的62-75%，且与给药方案和性别无关。代谢物1，即母化合物的葡萄糖醛酸苷，占剂量的4%到23%。代谢物组分2和3分别占剂量的高达3%和7%。提出的生物转化的主要途径是通过将芳香羟基与葡萄糖醛酸结合。在粪便排泄之前，肠道的水解作用将结合物转化回母化合物，导致肠肝循环。这表明，尽管粪便中的主要残留物是由于未改变的母化合物，但吸收率接近给定剂量的100%。此外，环己基环的2、3和4位置发生了羟基化，随后形成了这些羟基化代谢物的葡萄糖醛酸和硫酸盐结合物。放射性残留物的鉴定范围为88%至99%，且与剂量和性别无关。

Metabolite characterization studies /in rats/ showed that the main component detected in excreta was the unchanged parent compound which accounted for 62-75% of the dose independent of the dosing regime and sex. Metabolite 1, the glucuronic acid conjugate of the parent compound, ranged from 4 to 23% of the dose. Metabolite fractions 2 and 3 accounted for up to 3 and 7% of the dose, respectively. The proposed major pathway for biotransformation is via conjugation of the aromatic hydroxyl group with glucuronic acid. Prior to fecal excretion, hydrolysis in the intestine converts the conjugate back to the parent compound giving rise to enterohepatic circulation. This demonstrates that, although the main residues in the feces are due to unchanged parent compound, the absorption rate is close to 100% of the given dose. Furthermore, hydroxylation took place in the positions 2, 3 and 4 of the cyclohexyl ring followed by formation of glucuronic acid and sulfate conjugates of these hydroxylated metabolites. Identification of radioactive residues ranged from 88 to 99% and was independent of dose and sex.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

识别和使用：戊菌酰胺是一种固体。戊菌酰胺是一种针对灰葡萄孢、果生链核盘菌、链核盘菌和核盘菌属的特定杀菌剂。人类暴露和毒性：戊菌酰胺在工程化的人类乳腺癌细胞中显示出抗雄激素的内分泌干扰活性。戊菌酰胺在MCF-7、T47D和MDA-MB-231人类乳腺癌细胞中增加miR-21表达，并具有下游的抗雌激素活性。动物研究：当戊菌酰胺涂抹在兔子的皮肤上时，有轻微刺激性；当滴入同种动物的眼睛中时，有最小程度的刺激性。采用Buehler方法的豚鼠皮肤致敏试验结果为阴性。在一项为期1年的狗口服慢性毒性研究中，雄性/雌性在最低观察到有害作用剂量（LOAEL）124/133 mg/kg/天时，出现红细胞（RBC）计数、血红蛋白和血细胞比容降低，以及红细胞中Heinz小体增加；此外，在雌性中，绝对和相对肾上腺重量增加与肾上腺皮质内质网空泡发生率及严重程度增加的组织病理学观察相关。在一项发育毒性研究中，戊菌酰胺在妊娠第6至18天通过灌胃给予16只雌性兔子，剂量分别为0、100、300或1000 mg/kg/天。在试验条件下，任何剂量下均未观察到与治疗相关的死亡、一般外观或行为的影响。在试验条件下，受试化合物在任何测试剂量下均未诱导任何与治疗相关的胎儿畸形或偏差。子宫内发育的所有影响均与母体毒性相关，因此没有明显的初级发育效应。戊菌酰胺在包括1000 mg/kg/天在内的限量剂量下不具有致畸性。戊菌酰胺在以下试验中进行了测试：反向基因突变-沙门氏菌，无论有无代谢激活均不具突变性；正向基因突变-HGPRT位点，无论有无代谢激活均不具突变性；微核试验-小鼠，不具突变性；非计划性DNA合成-大鼠肝细胞，不具突变性；染色体畸变-CHO细胞，无论有无代谢激活均不具突变性。生态毒性研究：戊菌酰胺对虹鳟鱼和蓝鳃太阳鱼有中等毒性，对羊头鱼有轻微毒性。对有益昆虫的戊菌酰胺毒性的研究是使用配方戊菌酰胺（50%活性成分）进行的。基于捕食螨和rove甲虫死亡的NOEC为2 kg/公顷配方戊菌酰胺。寄生蜂的NOEC为4 kg/公顷配方戊菌酰胺。

IDENTIFICATION AND USE: Fenhexamid is a solid. Fenhexamid is a specific fungicide for the control of Botrytis cinerea, Monilinia fructigena, Monilinia laxa, and Sclerotinia sclerotiorum. HUMAN EXPOSURE AND TOXICITY: Fenhexamid showed endocrine disruptor activity as antiandrogen in an androgen receptor reporter assay in engineered human breast cancer cells. Fenhexamid increase miR-21 expression with downstream antiestrogenic activity in MCF-7, T47D, and MDA-MB-231 human breast cancer cells. ANIMAL STUDIES: It was slightly irritating when applied to the skin of rabbits, and was minimally irritating when instilled into the eyes of the same species. Results of skin sensitization testing in guinea pigs, employing the Buehler method, were negative. A 1-yr chronic oral toxicity study in dogs was conducted, in which decreased red blood cell (RBC) counts, hemoglobin and hematocrit and increased Heinz bodies in RBC were seen at the LOAEL of 124/133 mg/kg/day in males/females; also, in females, increased absolute and relative adrenal weights correlated with histopathological observations of increases in the incidence and severity of intracytoplasmic vacuoles in the adrenal cortex. In a developmental toxicity study, fenhexamid was administered to 16 female rabbits by gavage at dose levels of 0, 100, 300 or 1000 mg/kg/day from days 6 through 18 of gestation. No treatment-related effects were seen on mortality, general appearance or behavior. Administration of the test compound did not induce any treatment-related fetal malformations or deviations at any of the doses tested under the conditions of this study. All effects on intrauterine development were correlated with maternal toxicity and, therefore, no primary developmental effect was evident. Fenhexamid was not teratogenic up to and including 1000 mg/kg/day, the limit dose. Fenhexamid was tested in the following assays: Reverse Gene Mutation -Salmonella, non-mutagenic with or without metabolic activation; Forward Gene Mutation -HGPRT locus, non-mutagenic with or without metabolic activation; Micronucleus Assay -Mice, non-mutagenic; Unscheduled DNA Synthesis -Rat hepatocytes, non-mutagenic; Chromosome Aberration -CHO cells, non-mutagenic with or without metabolic activation. ECOTOXICITY STUDIES: Fenhexamid is moderately toxic to rainbow trout and bluegill sunfish, and slightly toxic to sheepshead minnow. Studies on the toxicity of fenhexamid to beneficial insects were done with formulated fenhexamid (50% a.i.). The NOEC based on mortality of predacious mite and rove beetle was 2 kg formulated fenhexamid/ha. The NOEC for parasitic wasp was 4 kg formulated fenhexamid/ha.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：不太可能对人类致癌

Cancer Classification: Not Likely to be Carcinogenic to Humans

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性数据

LC50 (大鼠) > 5,057 毫克/立方米/4小时

LC50 (rat) > 5,057 mg/m3/4h

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

在这个研究中，调查了两种杀菌剂，fenhexamid 和 myclobutanil 单独使用以及联合使用对两种人类细胞系，SH-SY5Y 神经细胞和 U-251 MG 胶质细胞的影响。在用从 1 到 1000 微摩尔的递增浓度的农药孵化 48 小时后，研究了基因表达谱以及毒性终点，包括细胞活力、线粒体去极化以及细胞谷胱甘肽的维持。在单独或联合给药时，两种细胞系在细胞活力评估或线粒体膜电位方面的敏感性没有显著差异。相比之下，在杀菌剂存在的情况下，SH-SY5Y 细胞在总巯基耗竭方面显示出对氧化应激的显著更高的敏感性，与星形细胞相比。用这两种农药处理导致细胞系中调节细胞周期控制和生长（RB1、TIMP1）以及对 DNA 损伤（ATM 和 CDA25A）和凋亡控制（FAS）的响应的几个基因的表达显著变化。没有证据表明在这项研究中，fenhexamid 和 myclobutanil 的组合比单独暴露显著更有毒性，尽管基因表达变化表明两种细胞系对单独和联合暴露的亚致死反应可能存在差异。

... In this study, the effects of two fungicides, fenhexamid and myclobutanil were investigated individually and in combination on two human cell lines, SH-SY5Y neuronal cells and U-251 MG glial cells. After 48 hr of incubation with increasing concentrations of pesticides ranging from 1 to 1000 uM, gene expression profiles were studied in addition to toxicity end points, including cell viability, mitochondrial depolarization as well as cellular glutathione maintenance. There were no significant differences between the susceptibility of the two cell lines in terms of cell viability assessment or mitochondrial membrane potential, when agents were administered either individually or in combination. By contrast, in the presence of the fungicides, the SH-SY5Y cells showed significantly greater susceptibility to oxidative stress in terms of total thiol depletion in comparison with the astrocytic cells. Treatment with the two pesticides led to significant changes in the cell lines' expression of several genes which regulate cell cycle control and growth (RB1, TIMP1) as well as responses to DNA attrition (ATM and CDA25A) and control of apoptosis (FAS). There was no evidence in this study that the combination of fenhexamid and myclobutanil was significantly more toxic than individual exposure, although gene expression changes suggested there may be differences in the sub-lethal response of both cell lines to both individual and combined exposure.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

迅速且完全吸收/排泄（<48小时）在大鼠体内；明显的肠肝循环。胆汁中的代谢物是葡萄糖苷酸；主要排泄途径是粪便（大部分为原形）；尿液中较少（大部分为葡萄糖苷酸）。

Rapidly and completely absorbed/excreted (<48 hours) /in rats/; pronounced enterohepatic circulation. Metabolite in bile- glucuronide; major route of excretion/feces (mostly parent); lesser amounts in urine (mostly glucuronide).

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在大鼠身上，10小时后，平均皮肤吸收率为20%（低剂量组）。（来自表格）

At 10 hours, mean dermal absorption /in rats/ was 20% (low dose group). /From table/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

KBR 2738/(纯净的 Fenhexamid)/在雄性和雌性Wistar大鼠体内的吸收、分布、代谢和排泄进行了研究，研究对象接受了单次口服低剂量1 mg/kg，单次口服高剂量100 mg/kg以及15次重复低剂量1 mg/kg/天。结果显示，(14)C-KBR 2738在各剂量组中均能迅速从胃肠道（GI）吸收。在单次和重复给予低剂量后，血药浓度在5到10分钟内达到峰值。在高剂量给药后，最大值在给药后40至90分钟被检测到。通过胆汁插管实验表明，测试化合物的吸收几乎是完全的，因为给药后48小时，超过97%的给药剂量从GI道被吸收。这些结果表明有明显的首次通过效应和肠肝循环。组织残留物迅速下降，48小时后，体内除GI道外的总放射性残留物在所有剂量组中均小于给药剂量的0.3%。肝脏和肾脏是所有剂量组中放射性浓度最高的器官。没有生物积累的证据。排泄迅速且几乎完全，粪便为主要排泄途径。大约62-81%的回收放射性物质在粪便中，48小时内15-36%在尿液中。在胆汁插管实验中，超过90%的回收放射性物质随胆汁排出。只有0.02%的给药放射性物质在呼出的空气中回收。在单次高剂量后，雌性大鼠体内的放射性残留物（不包括GI道）显著低于雄性。在15次重复低剂量后，雌性的肾排泄量显著高于雄性。在单次低剂量与单次高剂量相比，无论性别，肾排泄量都显著更高。

The absorption, distribution, metabolism and excretion of [Phenyl-UL-(14)C] KBR 2738 /(pure Fenhexamid)/ in male and female Wistar rats was determined after a single oral low dose of 1 mg/kg, a single oral high dose of 100 mg/kg and 15 repeated low doses of 1 mg/kg/day. (14)C-KBR 2738 was rapidly absorbed from the gastrointestinal (GI) tract in all dose groups. After single and repeated administration of the low dose, the plasma concentration peaked within 5 to 10 minutes. After administration of the high dose, the maximum was detected 40 to 90 minutes post-dosing. The absorption of the test compound was shown to be almost complete in a bile-cannulation experiment, as more than 97% of the administered dose was absorbed from the GI tract 48 hours after intraduodenal administration. These results are indicative of a pronounced first pass effect and enterohepatic circulation. Tissue residues declined rapidly and after 48 hours the total radioactivity residue in the body, excluding the GI tract, was <0.3% of the administered dose in all dose groups. Liver and kidney were the organs with the highest concentrations of radioactivity in all dose groups. There was no evidence of bioaccumulation. Excretion was rapid and almost complete with feces as the major route of excretion. Approximately 62-81% of the recovered radioactivity was found in feces, and 15-36% in urine within 48 hours post-dosing. More than 90% of the recovered radioactivity was eliminated with bile in the bile cannulation experiment. Only 0.02% of the administered radioactivity was recovered in exhaled air. Radioactive residues in rat bodies (excluding GI tract) were significantly lower in females after a single high dose. There was significantly higher renal excretion for females in comparison with males after 15 repeated low doses. In both sexes renal excretion was significantly higher after a single low dose when compared with a single high dose.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在为期56天的生物利用度研究中，将95.4%纯度的KBR 2738以1%花生油辅料掺入饲料中，给予SPF级培育的Wistar大鼠（每组每种性别10只），剂量水平为0、1000、5000、10,000、15,000或20,000 ppm（对于雄性分别为57.5、284.7、575.7、943.8和1217.1 mg/kg/天，对于雌性分别为78.0、407.1、896.5、1492.5和1896.7 mg/kg/天），持续56天。本研究的目的是确定在饲料中以10,000至20,000 ppm浓度给予KBR 2738时，是否会发生肠道吸收的饱和。因此，在预计达到稳态条件的治疗3或4周后，测定了血浆和尿液样本中的KBR 2738水平。结果显示，从20,000 ppm剂量大鼠采集的血浆样本中KBR 2738的水平低于检测限。尿液样本显示可测量的结合型KBR 2738排泄，表明在所考察的剂量范围内存在肠道吸收。雄性在15,000 ppm时达到最大排泄率，表明在15,000至20,000 ppm之间肠道吸收达到饱和。在10,000 ppm及以上浓度下，雌性的尿液排泄量略低于雄性。在20,000 ppm时达到最高值，这表明在这个剂量水平下雌性并未达到肠道吸收的饱和。

In a 56-day bioavailability study, KBR 2738 (95.4% purity) was administered to 10/sex/dose SPF-bred Wistar rats in their diet (1% peanut oil excipient) at dose levels of 0, 1000, 5000, 10,000, 15,000 or 20,000 ppm (57.5, 284.7, 575.7, 943.8, and 1217.1 mg/kg/day for males and 78.0, 407.1, 896.5, 1492.5 and 1896.7 mg/kg for females) for 56 days. The purpose of this study was to determine whether or not there was saturation of intestinal absorption of KBR 2738 when given in the diet at concentrations of 10,000 to 20,000 ppm. Therefore, KBR 2738 levels were determined in plasma and urine samples after a treatment period of 3 or 4 weeks, when steady state conditions were expected. Results showed that plasma samples taken from 20,000 ppm rats had KBR 2738 levels below the limit of detection. Urine samples showed measurable excretion of conjugated KBR 2738 indicating intestinal absorption in the dose range examined. Males had a maximum excretion rate at 15,000 ppm indicating a saturation of intestinal absorption between 15,000 and 20,000 ppm. Urine excretion in females was somewhat lower than in males, at concentrations of 10,000 ppm and above. The highest value was determined at 20,000 ppm suggesting that saturation in intestinal absorption was not achieved with this dose level in females.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  9
• 危险品标志：
  N,
• 安全说明：
  S61
• 危险类别码：
  R51/53
• WGK Germany：
  2
• 危险品运输编号：
  UN 3077 9/PG 3
• RTECS号：
  GU7879550
• 包装等级：
  III
• 危险类别：
  9
• 危险性防范说明：
  P264,P270,P273,P280,P301+P312+P330,P302+P352+P312,P305+P351+P338+P310,P332+P313,P391,P501
• 危险性描述：
  H302+H312,H315,H318,H411

制备方法与用途

用途

适宜作物：葡萄、硬果、草莓、蔬菜、柑橘、观赏植物等。对作物、人类及环境安全，是理想的综合害虫治理用药。

防治对象

主要防治各种灰霉病以及相关的菌核病、黑斑病等。

使用方法

本品作为叶面杀菌剂使用，剂量为500~1000g(a.i.)/hm²。对灰霉病具有特效。

合成方法

以环己酮和2,3-二氯硝基苯为起始原料，经过以下反应制得目标产物：

毒性

大小鼠急性经口LD₅₀ > 5000mg/kg。大鼠急性经皮LD₅₀ > 5000mg/kg。大鼠急性吸入LC₅₀(4h) > 5057mg/kg空气。本品对兔眼睛和皮肤无刺激性。

动物长期饲喂实验结果如下：

• 大鼠：雄鼠28mg/(kg·d)，雌鼠40mg/(kg ·d)(24个月)
• 小鼠：800mg/kg(雄鼠247.4mg/(kg·d)，雌鼠364.8mg/(kg·d))
• 狗：18.3mg/(kg ·d)(12个月)

该产品无致畸、致癌、致突变作用。

反应信息

• 作为反应物：
  描述：

  3-氯苯并ób]噻酚-2-羰酰氯 、 环酰菌胺 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以91%的产率得到3-chlorbenzothiophen-2-carboxylic acid 4-(1-methylcyclohexyl)carbonylamino-2,3-dichlorphenyl ester
  参考文献：
  名称：

  Aminophenolderivate

  摘要：

  这项发明涉及新的氨基酚衍生物，其制备方法以及作为杀真菌剂的用途。

  公开号：

  EP1477485A1
• 作为产物：
  描述：

  二氯-苯酚 在 盐酸 、 sodium dithionite 、 三乙胺 、 sodium hydroxide 作用下， 以 乙醇 、 水 、 乙酸乙酯 为溶剂， 反应 11.9h， 生成 环酰菌胺
  参考文献：
  名称：

  一种环酰菌胺及其合成方法

  摘要：

  本发明公开了一种环酰菌胺及其合成方法，包括以下原料：苯胺、盐酸、亚硝酸钠溶液、2，3－二氯苯酚、氢氧化钠、水、乙醇、保险粉、1－甲基环已酸、二氯甲烷、N，N‑二甲基甲酰胺、氯化亚砜、乙酸乙酯和三乙胺。本发明所得的该环酰菌胺的含量在98％以上，收率达到86～87％，在环酰菌胺合成过程中，偶氮物还原生成2,3－二氯－4－羟基苯胺时，采用保险粉还原，保险粉的还原性强，在弱碱性还原反应速度快，将氢氧化钠和保险粉交叉投入，可使转化率在98％以上，并且加完保险粉有反酸现象，最终使pH维持在6～7之间。环酰菌胺的生产条件温和，易操作，安全性高，总收率高，成本低，适用于企业规模化生产和应用。

  公开号：

  CN108689875A

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• [EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
  申请人：BASF SE

  公开号：WO2014206910A1

  公开（公告）日：2014-12-31

  The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及公式（I）中变量如索权和说明中所定义的自行车基取代异噻唑啉化合物。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] AZOLINE COMPOUNDS<br/>[FR] COMPOSÉS AZOLINE
  申请人：BASF SE

  公开号：WO2015128358A1

  公开（公告）日：2015-09-03

  The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式（I）的噁唑啉化合物，其中A、B1、B2、B3、G1、G2、X1、R1、R3a、R3b、Rg1和Rg2如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] SUBSTITUTED QUINAZOLINES AS FUNGICIDES<br/>[FR] QUINAZOLINES SUBSTITUÉES, UTILISÉES EN TANT QUE FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2010136475A1

  公开（公告）日：2010-12-02

  The present invention relates to a compound of formula (I) wherein wherein the substituents have the definitions as defined in claim 1or a salt or a N-oxide thereof, their use and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

  本发明涉及一种具有如下式（I）的化合物，其中取代基具有权利要求1中定义的定义，或其盐或N-氧化物，它们的用途以及用于控制和/或预防植物中微生物感染，特别是真菌感染的方法，以及制备这些化合物的方法。
• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。

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