3-[4-[[Bis(pyridin-2-ylmethyl)amino]methyl]triazol-1-yl]-7-(diethylamino)chromen-2-one | 1271725-09-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-[4-[[Bis(pyridin-2-ylmethyl)amino]methyl]triazol-1-yl]-7-(diethylamino)chromen-2-one
• 英文别名: 3-[4-[[bis(pyridin-2-ylmethyl)amino]methyl]triazol-1-yl]-7-(diethylamino)chromen-2-one
• CAS: 1271725-09-7
• 化学式: C₂₈H₂₉N₇O₂
• 分子量: 495.584
• InChiKey: JCKKTTVQRWIAOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.3
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  二甲基吡啶胺 在 copper(ll) sulfate pentahydrate 、 potassium carbonate 、 sodium ascorbate 作用下， 以 乙醇 、 水 、 甲苯 、 乙腈 为溶剂， 反应 24.0h， 生成 3-[4-[[Bis(pyridin-2-ylmethyl)amino]methyl]triazol-1-yl]-7-(diethylamino)chromen-2-one
  参考文献：
  名称：

  Visualization of Nitroxyl in Living Cells by a Chelated Copper(II) Coumarin Complex

  摘要：

  The coumarin-based probe Cu(II)-COT1 was successfully developed for the detection of HNO on the basis of the reduction reaction. In addition, highly selective "turn on" type fluorogenic behavior upon the addition of Angeli's salt (Na2N2O3) was also applied to bioimaging in A375 cells.

  DOI：

  10.1021/ol103077q

文献信息

• Visualization of Nitroxyl in Living Cells by a Chelated Copper(II) Coumarin Complex
  作者：Yi Zhou、Ke Liu、Ju-Ying Li、Yuan Fang、Tian-Chu Zhao、Cheng Yao

  DOI：10.1021/ol103077q

  日期：2011.3.18

  The coumarin-based probe Cu(II)-COT1 was successfully developed for the detection of HNO on the basis of the reduction reaction. In addition, highly selective "turn on" type fluorogenic behavior upon the addition of Angeli's salt (Na2N2O3) was also applied to bioimaging in A375 cells.