3,3-dihydroperoxy-1,5-bis(4'-methoxyphenyl)pentane | 1374458-50-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,3-dihydroperoxy-1,5-bis(4'-methoxyphenyl)pentane
• 英文别名: 1-[3,3-Dihydroperoxy-5-(4-methoxyphenyl)pentyl]-4-methoxybenzene
• CAS: 1374458-50-0
• 化学式: C₁₉H₂₄O₆
• 分子量: 348.396
• InChiKey: IGWPXMZIYABWGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (1E,4e)-1,5-双(4-甲氧基苯基)-1,4-戊二烯-3-酮 在 phosphomolybdic acid 、 palladium 10% on activated carbon 、 氢气 、 双氧水 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 20.0 ℃ 、27.58 kPa 条件下， 反应 6.0h， 生成 3,3-dihydroperoxy-1,5-bis(4'-methoxyphenyl)pentane
  参考文献：
  名称：

  Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives

  摘要：

  Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.

  DOI：

  10.1111/j.1747-0285.2012.01345.x

文献信息

• Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives
  作者：Lucas Lopardi Franco、Mauro Vieira de Almeida、Luiz Francisco Rocha e Silva、Pedro Paulo Ribeiro Vieira、Adrian Martin Pohlit、Marcelo Siqueira Valle

  DOI：10.1111/j.1747-0285.2012.01345.x

  日期：2012.5

  Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.