2-ethoxybutyric acid | 56674-70-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-ethoxybutyric acid
• 英文别名: α-methoxybutyric acid；2-ethoxy-butyric acid；2-Aethoxy-buttersaeure；α-Aethoxy-buttersaeure；2-Ethoxy-buttersaeure；2-Ethoxybutanoic acid
• CAS: 56674-70-5
• 化学式: C₆H₁₂O₃
• mdl: MFCD12067177
• 分子量: 132.159
• InChiKey: JEPGPKGGSYXGKV-UHFFFAOYSA-N

物化性质

• 沸点：
  82-84 °C(Press: 10 Torr)
• 密度：
  0.9931 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethoxybutyric acid 在 氯化亚砜 作用下， 生成 2-Ethoxybutanoyl chloride
  参考文献：
  名称：

  新合成的氟轻松 C-21 酯的溶剂分解动力学研究——一种前药活化的体外模型。

  摘要：

  在这项研究中，新合成的氟轻松 C-21 酯的溶剂分解与氟轻松在 24 小时的时间段内进行了比较。使用过量的 NaHCO 3 在乙醇-水 (90:10 v/v) 混合物中进行溶剂分解。已通过 RP-HPLC 方法使用甲醇-水 (75:25 v/v) 等度洗脱对每种研究的酯的溶剂分解混合物进行了测定；流速 1 mL/min；238 nm 检测；温度 25 °C。从获得的数据计算溶剂分解速率常数。几何优化和电荷计算由 Gaussian W03 软件进行。在溶剂分解速率常数和这些酯的 C-O2 键的极性之间获得了良好的相关性 (R = 0.9924)。

  DOI：

  10.3390/molecules16032658
• 作为产物：
  描述：

  sodium ethanolate 、 2-溴丁酸乙酯 生成 2-ethoxybutyric acid
  参考文献：
  名称：

  Duvillier, Annales de Chimie (Cachan, France), 1879, vol. <5>17, p. 532

  摘要：

  DOI：

文献信息

• 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof
  申请人：MUNEAUX Yvette

  公开号：US20080262020A1

  公开（公告）日：2008-10-23

  The disclosure relates to compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , are R 5 are as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.

  该公开涉及到式(I)的化合物： 其中R1、R2、R3、R4、R5如本公开所定义；它们的制备方法，含有这些化合物的组合物以及它们的治疗用途。
• Chemical amplification type resist composition
  申请人：Yamada Airi

  公开号：US20080269506A1

  公开（公告）日：2008-10-30

  The present invention provides a sulfonium salt of the formula (Ia) a polymeric compound comprising a structural unit of the formula (Ib) and a chemical amplification type positive resist composition comprising (A) an acid generator comprising at least one compound selected from the group consisting of a sulfonium salt of the formula (Ia), a polymeric compound comprising a structural unit of the formula (Ib), and a sulfonium salt of the formula (Ic); and (B) resin which contains a structural unit having an acid labile group and which itself is insoluble or poorly soluble in an alkali aqueous solution but becomes soluble in an alkali aqueous solution by the action of an acid.

  本发明提供了一种公式(Ia)的硫鎓盐，包括一个结构单元的聚合物化合物的公式(Ib)，以及一种化学放大型正性光刻胶组合物，包括(A)至少选择自硫鎓盐的公式(Ia)、一个结构单元的聚合物化合物的公式(Ib)和硫鎓盐的公式(Ic)组成的酸发生剂；以及(B)含有酸敏感基团的结构单元的树脂，本身在碱性水溶液中不溶或难溶，但在酸的作用下变得可溶于碱性水溶液。
• COMPOSITION, FILM, NEAR INFRARED CUT FILTER, LAMINATE, PATTERN FORMING METHOD, SOLID IMAGE PICKUP ELEMENT, IMAGE DISPLAY DEVICE, INFRARED SENSOR, AND COLOR FILTER
  申请人：FUJIFILM Corporation

  公开号：US20180305552A1

  公开（公告）日：2018-10-25

  The composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23° C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.

  该组合物包括两种或更多在波长范围为650到1000纳米具有吸收峰值的近红外吸收化合物，并且在23°C下其在水中的溶解度为0.1质量%或更低。其中，这两种或更多的近红外吸收化合物包括第一种在波长范围为650到1000纳米具有吸收峰值的近红外吸收化合物，以及第二种在波长范围为650到1000纳米具有比第一种近红外吸收化合物吸收峰值更短的吸收峰值的近红外吸收化合物，第一种近红外吸收化合物的吸收峰值与第二种近红外吸收化合物的吸收峰值之间的差值为1到150纳米。
• [EN] NEUTRAL ENDOPEPTIDASE INHIBITOR POLYMORPH<br/>[FR] POLYMORPHE INHIBITEUR D'ENDOPEPTIDASE NEUTRE
  申请人：PFIZER LTD

  公开号：WO2005123702A1

  公开（公告）日：2005-12-29

  Disclosed are (2S)-2-1-[(1S)-1-Isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric, Potassium-(2S)-2-1-[(1S)-1-Isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyrate, monohydrate and its Form I polymorph. Also disclosed are compositions of the described forms, kits including the described forms, and methods of using the described forms for the treatment diseases or disorders where the use of a neutral endopeptidase inhibitor is indicated, including cardiovascular diseases and conditions.

  披露了(2S)-2-1-[(1S)-1-异丁氧羰基-2-(5-苯基-噁唑-2-基)-乙基氨基]-环戊甲基}-4-甲氧基丁酸钾盐、(2S)-2-1-[(1S)-1-异丁氧羰基-2-(5-苯基-噁唑-2-基)-乙基氨基]-环戊甲基}-4-甲氧基丁酸盐、单水合物及其I型多形体。还披露了所述形式的组合物、包含所述形式的试剂盒，以及使用所述形式治疗心血管疾病和症状等需要使用中性内肽酶抑制剂的疾病或疾病的方法。
• [EN] ANTIMICROBIAL COMPOPSITION COMPRISING A POLYMERIC BIGUANIDE AND A COPOLYMER AND THEIR USE THEREOF<br/>[FR] COMPOSITION ANTIMICROBIENNE CONTENANT UN BIGUANIDE POLYMERIQUE ET UN COPOLYMERE ET UTILISATION ASSOCIEE
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100663A1

  公开（公告）日：2004-11-25

  The present invention relates to a composition comprising: (i) an antimicrobial agent; and (ii) a non-ionic co-polymer of Formula (1) wherein: [A] is of Formula (9), [B] is of Formula (10), and [X] is of Formula (11), wherein [A] and [B] may be in any order; T is an optionally substituted substituent; L is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted C1-20-alkyl or optionally substituted C 3-20-cycloalkyl; R4 and R5 are each independently H or C1-4alkyl; q is 15 to 1000; p is 3 to 50; and the molar ratio of [A] to [B] (m:n), is 1:10 to 10:1; provided that R1, R2, R3, T and L do not contain an ionisable group and provided that at least one of R4 and R5 is H.

  本发明涉及一种组合物，包括：(i)一种抗菌剂；和(ii)一种非离子共聚物，其化学式为(1)，其中：[A]的化学式为(9)，[B]的化学式为(10)，[X]的化学式为(11)，其中[A]和[B]可以以任何顺序存在；T是可选的取代基；L是可选的取代连接基；R1、R2和R3分别是H、可选的取代C1-20烷基或可选的取代C3-20环烷基；R4和R5分别是H或C1-4烷基；q为15至1000；p为3至50；[A]与[B]的摩尔比(m:n)为1:10至10:1；但要求R1、R2、R3、T和L不含有离子化基团，并且至少有一个R4和R5是H。