(E)-5-bromo-2,3-dihydro-1H-inden-1-one oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (E)-5-bromo-2,3-dihydro-1H-inden-1-one oxime
• 英文别名: 5-Bromo-1-indanone oxime；(NZ)-N-(5-bromo-2,3-dihydroinden-1-ylidene)hydroxylamine
• 化学式: C₉H₈BrNO
• 分子量: 226.073
• InChiKey: FKVWLYRRDKFLBM-LUAWRHEFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-5-bromo-2,3-dihydro-1H-inden-1-one oxime 在 溶剂黄146 、 锌 作用下， 反应 48.0h， 以59%的产率得到5-溴-2,3-二氢-1H-茚-1-胺
  参考文献：
  名称：

  [EN] INDANE DERIVATIVES
  [FR] DÉRIVÉS D'INDANE

  摘要：

  本发明涉及一种根据式I定义的邻二氢茚衍生物，其中变量如规范中所定义，或其药学上可接受的盐或溶剂。本发明还涉及一种含有一种或多种所述邻二氢茚衍生物的制药组合物，以及它们在治疗中的应用，例如在需要增强由AMPA受体介导的突触反应的精神疾病治疗或预防中，包括精神分裂症、抑郁症和阿尔茨海默病。

  公开号：

  WO2010115952A1
• 作为产物：
  描述：

  5-溴茚酮 在 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以87%的产率得到(E)-5-bromo-2,3-dihydro-1H-inden-1-one oxime
  参考文献：
  名称：

  [EN] INDANE DERIVATIVES
  [FR] DÉRIVÉS D'INDANE

  摘要：

  本发明涉及一种根据式I定义的邻二氢茚衍生物，其中变量如规范中所定义，或其药学上可接受的盐或溶剂。本发明还涉及一种含有一种或多种所述邻二氢茚衍生物的制药组合物，以及它们在治疗中的应用，例如在需要增强由AMPA受体介导的突触反应的精神疾病治疗或预防中，包括精神分裂症、抑郁症和阿尔茨海默病。

  公开号：

  WO2010115952A1

文献信息

• ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20170137385A1

  公开（公告）日：2017-05-18

  A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

  式（I）的化合物：其中取代基如描述中所定义。含有相同化合物的药品，可用于治疗或预防由RhoA/ROCK途径的激活和肌球蛋白轻链的磷酸化所导致的病理。
• INDANE DERIVATIVES
  申请人：Gillen Kevin James

  公开号：US20120202781A1

  公开（公告）日：2012-08-09

  The present invention relates to anindane derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said indane derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.

  本发明涉及一种按照公式I定义的indane衍生物，其中变量如规范中所定义，或其药学上可接受的盐或溶剂。本发明还涉及一种包括一种或多种所述indane衍生物的制药组合物，并且涉及它们在治疗中的应用，例如在需要增强由AMPA受体介导的突触反应的精神疾病的治疗或预防中，包括精神分裂症、抑郁症和阿尔茨海默病。
• PROCESS FOR THE PREPARATION OF PYRROLINES FROM GAMMA-NITROKETONES. USE OF THE GAMMA-NITROKETONES AS PESTICIDAL AGENTS
  申请人：Moradi Wahed Ahmed

  公开号：US20130109757A1

  公开（公告）日：2013-05-02

  The invention is directed to method for the preparation of pyrrolines of the general formula (I) by catalytic hydration of a nitroketone of the general formula (II) employing a transition metal catalyst and gaseous hydrogen at an elevated pressure in a solvent, optionally in the presence of at least one additive selected among Lewis acids, Brønstedt acids, organic sulfur-containing compounds, organic or inorganic bases, and water scavengers, wherein in formulae (I) and (II) B 1 , B 2 , B 3 , B 4 , X, R, and T are as defined in the specification, and to a nitroketone of formula (II) to be used as intermediate in the process according to the invention and as pesticidal agent.

  本发明涉及一种制备一般式为（I）的吡咯烷的方法，通过在溶剂中使用过渡金属催化剂和气态氢，在升高的压力下催化水合一般式为（II）的硝基酮，可选地，在Lewis酸，Brønstedt酸，有机含硫化合物，有机或无机碱和水清除剂中选择至少一种添加剂的存在下进行，其中在公式（I）和（II）中，B1，B2，B3，B4，X，R和T如规范所定义，并提供了一种公式（II）的硝基酮作为本发明中间体和杀虫剂。
• Pesticide Compounds
  申请人：BASF SE

  公开号：US20160157491A1

  公开（公告）日：2016-06-09

  The present invention relates to novel compounds of the formula I and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein C 1 is C or CH; C 2 is C or CH; A 1 is N or C; A 2 is N, C(R 2 ), N(R 3 ), O, S or C(R 4 ,R 5 ); and A 3 is N, O, S, N(R 6 ), C(R 7 ) or C(R 8 ,R 9 ); where one or two non-adjacent bonds in the 5-membered ring formed by C 1 , C 2 , A 1 , A 2 and A 3 are double bonds, while the others are single bonds, provided that the bond between A 1 and A 2 or the bond between A 1 and C 1 or the bond between A 2 and A 3 or the bond between C 1 and C 2 or the bond between A 3 and C 2 is a double bond further provided that at least one of A 1 , A 2 and A 3 is N, N(R 3 ) or N(R 6 ), and where Ar, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and (R) k are as defined in the claims and in the description, which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式I及其N-氧化物、立体异构体、互变异构体和农业或兽医可接受的盐的新化合物，其中C1为C或CH; C2为C或CH; A1为N或C; A2为N、C（R2）、N（R3）、O、S或C（R4，R5）; A3为N、O、S、N（R6）、C（R7）或C（R8，R9）; 在由C1、C2、A1、A2和A3形成的5元环中，一个或两个非相邻的键为双键，而其他键为单键，前提是A1和A2之间的键或A1和C1之间的键或A2和A3之间的键或C1和C2之间的键或A3和C2之间的键为双键，进一步前提是A1、A2和A3中至少有一个为N、N（R3）或N（R6），其中Ar、R1、R2、R3、R4、R5、R6、R7、R8、R9和（R）k如权利要求和说明书中所定义，该化合物对于防治或控制无脊椎动物害虫，特别是节肢动物害虫和线虫有用。本发明还涉及使用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料和农业和兽医组合物。
• AZOLOBENZAZINE COMPOUNDS, COMPOSITIONS COMPRISING THESE COMPOUNDS AND THEIR USE FOR CONTROLLING INVERTEBRATE PESTS
  申请人：BASF SE

  公开号：US20180002346A1

  公开（公告）日：2018-01-04

  Azolobenzazine compounds of the formula I and N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof are disclosed, as well as are methods for controlling invertebrate pests using the disclosed compounds. Further disclosed are plant propagation materials, agricultural compositions, and veterinary compositions that include the disclosed compounds.