methyl 3-(2,3-dihydrofuran-3-yl)propionate | 1275552-74-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 3-(2,3-dihydrofuran-3-yl)propionate
• 英文别名: Methyl 3-(2,3-dihydrofuran-3-yl)propanoate；methyl 3-(2,3-dihydrofuran-3-yl)propanoate
• CAS: 1275552-74-3
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: IKWSASKLDWSFDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-二氢呋喃 、 丙烯酸甲酯（MA） 在 Ru(η6-naphthalene)(η4-1,5-COD) 作用下， 反应 24.0h， 生成 methyl (E)-3-(2,3-dihydrofuran-3-yl)prop-2-enoate 、 methyl 3-(2,3-dihydrofuran-3-yl)propionate
  参考文献：
  名称：

  Prostereogenic Face and Orientation Selective Oxidative Coupling Reaction between Methyl Methacrylate and 2,5-Dihydrofuran Catalyzed by a Ruthenium(0) Compound

  摘要：

  We disclose the first prostereogenic face and orientational control of coordinated olefins in an oxidative coupling reaction at a transition-metal center. Chemo-, regio-, and diastereoselective cross-dimerization between methyl methacrylate (MMA) and 2,5-dihydrofuran is catalyzed by Ru(eta(6)-naphthalene)(eta(4)-1,5-COD) (1; S mol %) at 0 degrees C in 24 h without use of solvent to give methyl rac-(2S)-3-[(3R)-2,3-dihydrofuran-3-yl]-2-methy1propionate (2a) in 81% yield.

  DOI：

  10.1021/om200091n

文献信息

• Prostereogenic Face and Orientation Selective Oxidative Coupling Reaction between Methyl Methacrylate and 2,5-Dihydrofuran Catalyzed by a Ruthenium(0) Compound
  作者：Yuki Hiroi、Nobuyuki Komine、Masafumi Hirano、Sanshiro Komiya

  DOI：10.1021/om200091n

  日期：2011.3.28

  We disclose the first prostereogenic face and orientational control of coordinated olefins in an oxidative coupling reaction at a transition-metal center. Chemo-, regio-, and diastereoselective cross-dimerization between methyl methacrylate (MMA) and 2,5-dihydrofuran is catalyzed by Ru(eta(6)-naphthalene)(eta(4)-1,5-COD) (1; S mol %) at 0 degrees C in 24 h without use of solvent to give methyl rac-(2S)-3-[(3R)-2,3-dihydrofuran-3-yl]-2-methy1propionate (2a) in 81% yield.