(E)-4-(1H-indol-3-yl)-5-methylhept-5-en-2-one | 1330578-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-4-(1H-indol-3-yl)-5-methylhept-5-en-2-one
• 英文别名: (E,4S)-4-(1H-indol-3-yl)-5-methylhept-5-en-2-one
• CAS: 1330578-97-6
• 化学式: C₁₆H₁₉NO
• 分子量: 241.333
• InChiKey: ZTPKRDRJRRGCDS-BJTBTHHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-吲哚甲醛 在 (1R,3'r)-3,3'-bis(perfluorophenyl)[1,1'-binaphthalene]-2,2'-diol 、 magnesium 2-methylpropan-2-olate 作用下， 以 甲苯 为溶剂， 反应 38.0h， 生成 (E)-4-(1H-indol-3-yl)-5-methylhept-5-en-2-one
  参考文献：
  名称：

  Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-Appended Enones

  摘要：

  An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3'-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu)(2). A range of a-branched indole derivatives are available from the transformation.

  DOI：

  10.1021/ol2020847

文献信息

• Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-Appended Enones
  作者：Brian J. Lundy、Santa Jansone-Popova、Jeremy A. May

  DOI：10.1021/ol2020847

  日期：2011.9.16

  An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3'-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu)(2). A range of a-branched indole derivatives are available from the transformation.