7-Carbethoxyamino-4-methyl-6-nitro-coumarin | 79571-80-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-Carbethoxyamino-4-methyl-6-nitro-coumarin
• 英文别名: 4-Methyl-6-nitro-7-carbethoxyaminocoumarin；6-nitro-7-carbethoxyamino-4-methylcoumarin；ethyl N-(4-methyl-6-nitro-2-oxochromen-7-yl)carbamate
• CAS: 79571-80-5
• 化学式: C₁₃H₁₂N₂O₆
• 分子量: 292.248
• InChiKey: FMYNTYRRCJXIMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-Carbethoxyamino-4-methyl-6-nitro-coumarin 在 盐酸 、 tin 、 硫酸 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 4.0h， 生成 8-methylchromeno[7,6-d]imidazol-6(3H)-one
  参考文献：
  名称：

  Synthesis and fluorescence study of 6,7-diaminocoumarin and its imidazolo derivatives

  摘要：

  Novel 6,7-diamino-4-methylcoumarin and derived imidazolocoumarins were synthesized and their absorption and fluorescence properties were recorded in solvents of varying polarity. 6,7-Diamino-4-methylcoumarin is highly fluorescent, with a quantum yield of 0.78 in dioxane. The fluorescence intensity of 6,7-diamino-4-methylcoumarin, when mixed with different carbonyl group containing compounds, decreased. Based on the interaction of this diaminocoumarin with the carbonyl compound a fluorescent sensor with high selectivity towards electron rich benzaldehydes and cinnamaldehyde was developed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2012.08.021
• 作为产物：
  描述：

  (3-羟基-苯基)-氨基甲酸乙酯 在 硫酸 、 硝酸 作用下， 生成 7-Carbethoxyamino-4-methyl-6-nitro-coumarin
  参考文献：
  名称：

  甲基三唑并香豆素：呋喃香豆素的新等排体是潜在的光化学治疗剂

  摘要：

  合成了许多具有线性补骨脂素样结构或有角安吉辛样结构的新甲基三唑并香豆素。从合适的甲基化7-氨基香豆素开始进行合成，将其硝化，还原并随后伴随环化而重氮化以形成稠合的三唑环。新的甲基三唑并香豆素显示出有希望的光谱性质，这可能预示了它们的光化学和光生物学行为。

  DOI：

  10.1002/jhet.5570270464

文献信息

• Methyltriazolocoumarins: New furocoumarin isosters as potential photochemotherapeutic agents
  作者：P. Rodighiero、A. Chilin、G. Pastorini、A. Guiotto、P. Manzini

  DOI：10.1002/jhet.5570270464

  日期：1990.5

  A number of new methyltriazolocoumarins with a linear psoralen-like structure or an angular angelicin-like structure were synthetized. The syntheses were performed starting from the appropriate methylated 7-aminocoumarins which were nitrated, reduced and successively diazotized with concomitant cyclization to form the condensed triazolo ring. The new methyltriazolocoumarins show promising spectroscopic

  合成了许多具有线性补骨脂素样结构或有角安吉辛样结构的新甲基三唑并香豆素。从合适的甲基化7-氨基香豆素开始进行合成，将其硝化，还原并随后伴随环化而重氮化以形成稠合的三唑环。新的甲基三唑并香豆素显示出有希望的光谱性质，这可能预示了它们的光化学和光生物学行为。
• Intracellular detection of hazardous <b>Cd</b>²⁺ through a fluorescence imaging technique by using a nontoxic coumarin based sensor
  作者：Chanda Kumari、Dibyendu Sain、Ashish Kumar、Sushanta Debnath、Partha Saha、Swapan Dey

  DOI：10.1039/c6dt04833a

  日期：——

  A new coumarin based turn on fluorescent sensor (R1) was reported for the detection of highly hazardous Cd²⁺ with excellent selectivity and sensitivity without any interference of other metal ions.

  一种基于香豆素的开关型荧光传感器（R1）被报道用于检测高危的Cd²⁺，具有优秀的选择性和灵敏度，没有其他金属离子的干扰。
• Vara Prasad Rao, K.; Sundaramurthy, V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 8, p. 707 - 709
  作者：Vara Prasad Rao, K.、Sundaramurthy, V.

  DOI：——

  日期：——
• RODIGHIERO, P.;CHILIN, A.;PASTORINI, G.;GUIOTTO, A.;MANZINI, P., J. HETEROCYCL. CHEM., 27,(1990) N, C. 1153-1158
  作者：RODIGHIERO, P.、CHILIN, A.、PASTORINI, G.、GUIOTTO, A.、MANZINI, P.

  DOI：——

  日期：——
• RAO, K. VARA;SUNDARAMURTHY, V., INDIAN J. CHEM., 1981, 20, N 8, 707-709
  作者：RAO, K. VARA、SUNDARAMURTHY, V.

  DOI：——

  日期：——