1'-[[10-methyl-6H,7H-indolo[2,3-c]isoquinolin-5-one-6-yl]formyl]-3',5'-diphenylpyrazole | 1416780-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1'-[[10-methyl-6H,7H-indolo[2,3-c]isoquinolin-5-one-6-yl]formyl]-3',5'-diphenylpyrazole
• 英文别名: 6-(3,5-diphenylpyrazole-1-carbonyl)-10-methyl-7H-indolo[2,3-c]isoquinolin-5-one
• CAS: 1416780-24-9
• 化学式: C₃₂H₂₂N₄O₂
• 分子量: 494.552
• InChiKey: RVKSIBPNSZYPMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-methyl-6,7-dihydroindolo[2,3-c]isoquinolin-5-one 在 盐酸 、 一水合肼 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 1'-[[10-methyl-6H,7H-indolo[2,3-c]isoquinolin-5-one-6-yl]formyl]-3',5'-diphenylpyrazole
  参考文献：
  名称：

  Synthesis of some new indolo[2,3-c]isoquinolinyl pyrazoles, -1,3,4-oxadiazoles and their biological activities

  摘要：

  A new series of novel compounds [10-substituted 6H, 7H-indolo[2,3-c]isoquinolin-5-one-6-yl]carbohydrazides (3a-c), 1-[10-substituted 6H, 7H-indolo[2,3-c]isoquinolin-5-one-6-yl]fomyl-, -3',5'-dimethylpyrazoles (4a-c), -3',5'-diphenylpyrazoles (5a-c), -3'-methylpyrazol-5'-ones (6a-c) and -1',3',4'-oxidiazole-2'-thiones (7a-c) linked to indoloisoquinoline at position-6 through formyl bridge was prepared. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial and antioxidant activities. Compounds 4a, 4b, 5a, 5b, 5c, 6b, 7a, and 7c exhibited the maximum zone of inhibition against A. niger, A. flavus, and A. fumigatus. Compounds 4a, 5a, 5c, 6b, 6c, 7a, and 7b showed good antibacterial activity. Compounds 4b, 4c, 5b, 5c, 6a, 6b, 7a, 7b, and 7c showed good radical scavenging activity compared with standards.

  DOI：

  10.1007/s00044-012-0366-6

文献信息

• Synthesis of some new indolo[2,3-c]isoquinolinyl pyrazoles, -1,3,4-oxadiazoles and their biological activities
  作者：Anand R. Saundane、Vaijinath A. Verma、Katkar Vijaykumar

  DOI：10.1007/s00044-012-0366-6

  日期：2013.8

  A new series of novel compounds [10-substituted 6H, 7H-indolo[2,3-c]isoquinolin-5-one-6-yl]carbohydrazides (3a-c), 1-[10-substituted 6H, 7H-indolo[2,3-c]isoquinolin-5-one-6-yl]fomyl-, -3',5'-dimethylpyrazoles (4a-c), -3',5'-diphenylpyrazoles (5a-c), -3'-methylpyrazol-5'-ones (6a-c) and -1',3',4'-oxidiazole-2'-thiones (7a-c) linked to indoloisoquinoline at position-6 through formyl bridge was prepared. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial and antioxidant activities. Compounds 4a, 4b, 5a, 5b, 5c, 6b, 7a, and 7c exhibited the maximum zone of inhibition against A. niger, A. flavus, and A. fumigatus. Compounds 4a, 5a, 5c, 6b, 6c, 7a, and 7b showed good antibacterial activity. Compounds 4b, 4c, 5b, 5c, 6a, 6b, 7a, 7b, and 7c showed good radical scavenging activity compared with standards.