3-((E)-3,7-dimethyl-octa-2,6-dienyloxy)-4-methoxy-benzoic acid methyl ester | 212958-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((E)-3,7-dimethyl-octa-2,6-dienyloxy)-4-methoxy-benzoic acid methyl ester
• 英文别名: 3-(3,7-Dimethyl-octa-2,6-dienyloxy)-4-methoxy-benzoic acid methyl ester；methyl 3-[(2E)-3,7-dimethylocta-2,6-dienoxy]-4-methoxybenzoate
• CAS: 212958-38-8
• 化学式: C₁₉H₂₆O₄
• 分子量: 318.413
• InChiKey: PQRFTHJYHYQWSD-RVDMUPIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-((E)-3,7-dimethyl-octa-2,6-dienyloxy)-4-methoxy-benzoic acid methyl ester 在 lithium hydroxide 、 水 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 84.0h， 生成 3-((E)-3,7-dimethyl-octa-2,6-dienyloxy)-4-methoxy-benzoic acid methoxymethyl ester
  参考文献：
  名称：

  Phenyl-prenyl-ether derivatives for the treatment of cognitive neurodegenerative or neuronal diseases or disorders

  摘要：

  本发明涉及一类公式（I）的苯基-烯丙基-醚衍生物家族，以及它们在治疗认知、神经退行性或神经疾病或障碍，如阿尔茨海默病或帕金森病中的应用。本发明还涉及包含相同衍生物的制药组合物。此外，本发明针对化合物在制造用于治疗和/或预防认知、神经退行性或神经疾病或障碍的药物方面的使用。

  公开号：

  EP1886990A1
• 作为产物：
  描述：

  香叶基溴 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.75h， 以43%的产率得到3-((E)-3,7-dimethyl-octa-2,6-dienyloxy)-4-methoxy-benzoic acid methyl ester
  参考文献：
  名称：

  Phenyl-prenyl-ether derivatives for the treatment of cognitive neurodegenerative or neuronal diseases or disorders

  摘要：

  本发明涉及一类公式（I）的苯基-烯丙基-醚衍生物家族，以及它们在治疗认知、神经退行性或神经疾病或障碍，如阿尔茨海默病或帕金森病中的应用。本发明还涉及包含相同衍生物的制药组合物。此外，本发明针对化合物在制造用于治疗和/或预防认知、神经退行性或神经疾病或障碍的药物方面的使用。

  公开号：

  EP1886990A1

文献信息

• [EN] PHENYL-PRENYL DERIVATIVES, OF MARINE AND SYNTHETIC ORIGIN, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS<br/>[FR] DÉRIVÉS DE PHÉNYLE-PRÉNYLE D'ORIGINE MARINE ET SYNTHÉTIQUE, DESTINÉS AU TRAITEMENT DE MALADIES OU TROUBLES COGNITIFS, NEURODÉGÉNÉRATIFS OU NEURONAUX
  申请人：NOSCIRA SA

  公开号：WO2009098287A1

  公开（公告）日：2009-08-13

  The present invention is related to a family of phenyl-prenyl derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the compounds of formula (I) for medical use, particularly for the use for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder, and to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

  本发明涉及一类具有式（I）的苯基-烯丙基衍生物，以及它们在治疗认知、神经退行性或神经疾病或障碍，如阿尔茨海默病或帕金森病中的用途。本发明还涉及包含相同化合物的药物组合物。此外，本发明针对式（I）的化合物用于医疗用途，特别是用于治疗和/或预防认知、神经退行性或神经疾病或障碍，并且用于制造用于治疗和/或预防认知、神经退行性或神经疾病或障碍的药物的化合物。
• PHENYL-PRENYL DERIVATIVES, OF MARINE AND SYNTHETIC ORIGIN, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS
  申请人：Lopez Ogalla Javier

  公开号：US20110092591A1

  公开（公告）日：2011-04-21

  The present invention is related to a family of phenyl-prenyl derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the compounds of formula (I) for medical use, particularly for the use for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder, and to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

  本发明涉及一类公式（I）的苯基-异戊烯基衍生物家族，以及它们在治疗认知、神经退行性或神经性疾病或疾病方面的用途，例如阿尔茨海默病或帕金森病。本发明还涉及包含这些化合物的制药组合物。此外，本发明针对公式（I）的化合物用于医疗用途，特别是用于治疗和/或预防认知、神经退行性或神经性疾病或疾病的用途，以及将这些化合物用于制造治疗和/或预防认知、神经退行性或神经性疾病或疾病的药物。
• PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS
  申请人：Martinez Gil Ana

  公开号：US20100267827A1

  公开（公告）日：2010-10-21

  The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

  本发明涉及一类公式（I）的苯基-异戊烯醚衍生物家族，以及它们在治疗认知、神经退行性或神经疾病或障碍，如阿尔茨海默病或帕金森病方面的应用。本发明还涉及包含这些化合物的制药组合物。此外，本发明还涉及将这些化合物用于制造治疗和/或预防认知、神经退行性或神经疾病或障碍的药物。
• Synthesis of Geranyl Phenyl Ethers Based on the Cytotoxic Monoterpenoids from the Liverwort Genus <i>Trichocolea</i>
  作者：Seung-Hwa Baek、Nigel B. Perry、Rex T. Weavers

  DOI：10.1021/np980031w

  日期：1998.9.1

  The synthesis of three geranyl ethers, methyl 4-[(2E)-3,7-dimethyl-5-oxo-2,6-octadienyl}oxy]-3-methoxybenzoate (1), methyl 4-[(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxybenzoate (2), and methyl 4-[(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-hydroxybenzoate (3), previously isolated from New Zealand Trichocolea liverworts, is described. Differing reactivity of the hydroxy groups of methyl protocatachuate toward alkylation and the ability of alkyl groups to migrate from oxygen to an ortho-oxygen in these benzene derivatives are noted.
• [EN] PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS<br/>[FR] DÉRIVÉS DE PHÉNYL-PRÉNYL-ÉTHER DESTINÉS AU TRAITEMENT DE MALADIES COGNITIVES OU NEURONALES, DE TROUBLES COGNITIFS OU NEURONAUX, OU DE TROUBLES OU MALADIES DE NEURODÉGÉNÉRESCENCE
  申请人：NEUROPHARMA SA

  公开号：WO2008015241A1

  公开（公告）日：2008-02-07

  [EN] The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.
  [FR] La présente invention concerne une famille de dérivés de phényl-prényl-éther de formule (I) et leur utilisation pour traiter des maladies cognitives ou neuronales, des troubles cognitifs ou neuronaux, ou des troubles ou maladies de neurodégénérescence tels que la maladie d'Alzheimer ou la maladie de Parkinson. L'invention concerne également des compositions pharmaceutiques comprenant ces dérivés. L'invention a également pour objet l'utilisation des composés pour fabriquer un médicament destiné au traitement et/ou à la prévention d'une maladie cognitive ou neuronale, d'un trouble cognitif ou neuronal, ou d'un trouble ou d'une maladie de neurodégénérescence.