1,1-diphenyl-N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]methanimine | 1046045-78-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-diphenyl-N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]methanimine
• CAS: 1046045-78-6
• 化学式: C₃₀H₂₅N₃S
• 分子量: 459.615
• InChiKey: VENXUDIEWJURKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1-diphenyl-N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]methanimine 在 盐酸 、 sodium carbonate 作用下， 以 四氢呋喃 、 水 、 乙酸乙酯 为溶剂， 反应 2.0h， 以82%的产率得到4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)aniline
  参考文献：
  名称：

  WO2008/97835

  摘要：

  公开号：
• 作为产物：
  描述：

  二苯甲酮亚胺 、 4-(4-(4-bromophenyl)thiazol-2-yl)-2-propylpyridine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 2,2'-双(二苯基磷)联苯 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以98%的产率得到1,1-diphenyl-N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]methanimine
  参考文献：
  名称：

  WO2008/97835

  摘要：

  公开号：

文献信息

• Compositions and Methods for the Treatment of Metabolic and Related Disorders
  申请人：Uesugi Motonari

  公开号：US20140038984A1

  公开（公告）日：2014-02-06

  The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.

  本发明涉及一种用于治疗和/或预防一种或多种代谢性疾病的化合物，其利用A-B-C三部分结构，其中A、B和C是相同或不同的结构，例如，但不限于，含有或不含有取代的杂环、苯基或苯甲基环结构，并在此详细描述。本发明还提供了使用fatostatin A和/或其衍生物和/或类似物和/或A-B-C三部分化合物治疗和/或预防一种或多种代谢性疾病，例如肥胖症或糖尿病的方法。
• Methods and Compositions for the Treatment of Cancer and Related Hyperproliferative Disorders
  申请人：Uesugi Motonari

  公开号：US20140045854A1

  公开（公告）日：2014-02-13

  The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.

  本发明涉及通过给予具有一般三部分结构A-B-C的化合物的治疗有效量来治疗与细胞过度增殖相关的疾病的方法。在三部分结构A、B和C中，A、B和C可以是相同或不相同的结构，例如，但不限于，具有或不具有取代基的杂环、苯基或苄基环结构，并在此详细描述。该方法可以利用特定的化合物，例如，具有哌啶基、吡咯烷基或吡啶基A环、噻唑B环和苯基C环，这些环可以进一步独立地被取代。
• Methods and Compositions for the Treatment of Body Weight Related Disorders
  申请人：Uesugi Motonari

  公开号：US20160128985A1

  公开（公告）日：2016-05-12

  The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described.

  本发明涉及通过给予具有一般三部分结构A-B-C的化合物的治疗有效量，减轻需要减重的动物的体重的方法。在三部分结构中，A、B和C是相同或不相同的结构，例如，但不限于，具有或不具有取代基的杂环、苯基或苄基环结构，并在此详细描述。该方法可以利用特定的化合物，例如，具有哌啶基、吡咯啉基或吡啶基A环，噻唑B环和苯基C环，这些环可以进一步独立地进行取代。此外，本发明还提供了通过给予所述化合物的治疗有效量，增加动物的热原性而不减少瘦体重的方法。
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER AND RELATED HYPERPROLIFERATIVE DISORDERS
  申请人：UESUGI Motonari

  公开号：US20180071289A1

  公开（公告）日：2018-03-15

  The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.
• US9085566B2
  申请人：——

  公开号：US9085566B2

  公开（公告）日：2015-07-21