Selective Synthesis of 1-Functionalized-alkyl-1H-indazoles
摘要:
An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.
Selective Synthesis of 1-Functionalized-alkyl-1<i>H</i>-indazoles
作者:Kevin W. Hunt、David A. Moreno、Nicole Suiter、Christopher T. Clark、Ganghyeok Kim
DOI:10.1021/ol902050m
日期:2009.11.5
An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.