2-氰基戊酰胺 | 89600-72-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-氰基戊酰胺
• 英文名称: 2-cyano-valeric acid amide
• 英文别名: 2-Cyan-valeriansaeure-amid；cyanovaleramide；2-Cyan-pentansaeureamid；2-Propyl-cyanacetamid；Pentanamide, 2-cyano-；2-cyanopentanamide
• CAS: 89600-72-6
• 化学式: C₆H₁₀N₂O
• 分子量: 126.158
• InChiKey: JRZLXTBWVCJQFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  122 °C
• 沸点：
  299.4±23.0 °C(Predicted)
• 密度：
  1.032±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  2-氰基戊酰胺 在 四氢呋喃 、 甲醇 、 lithium aluminium tetrahydride 、 乙醚 、 sodium methylate 作用下， 生成 5-methyl-5-propyl-tetrahydro-pyrimidin-2-one
  参考文献：
  名称：

  Palazzo; Cecinati, Farmaco, Edizione Scientifica, 1956, vol. 11, p. 918,922

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氰基戊酸 在 苯酚 作用下， 生成 2-氰基戊酰胺
  参考文献：
  名称：

  �ber einige Versuche mit Cyanessigs�ure

  摘要：

  DOI：

  10.1007/bf01075442

文献信息

• Process for producing flexible polyurethane foam
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP2738192A1

  公开（公告）日：2014-06-04

  A composition and process useful to make flexible polyurethane foams and in particular flexible molded polyurethane foams is disclosed. The usage of dipolar aprotic liquids such as DMSO, DMI, sulfolane, N-methyl-acetoacetamide, N, N-dimethylacetoacetamide as well as glycols containing hydroxyl numbers OH# ≤ 1100 as cell opening aides for 2-cyanoacetamide or other similar molecules containing active methylene or methine groups to make a polyurethane foam is also disclosed. The advantage of using cell opener aids results in a) no foam shrinkage; b) lower use levels of cell opener; c) foam performance reproducibility d) optimum physical properties. In addition, combining the acid blocked amine catalyst together with the cell opener and the cell opener aid results in a less corrosive mixture as well as provides a method that does not require mechanical crushing for cell opening.

  本发明公开了一种用于制造软质聚氨酯泡沫，特别是软质模塑聚氨酯泡沫的组合物和工艺。本发明还公开了使用二极性烷基液体，如二甲基亚砜、二甲基亚砜、N-甲基乙酰乙酰胺、N, N-二甲基乙酰乙酰胺以及含有羟基数 OH# ≤ 1100 的乙二醇作为 2-氰基乙酰胺或其他含有活性亚甲基或甲基的类似分子的开孔助剂来制造聚氨酯泡沫。使用开孔助剂的优点是：a) 泡沫不会收缩；b) 开孔剂用量较少；c) 泡沫性能可再现；d) 物理性能最佳。此外，将酸性封端胺催化剂与开孔剂和开孔助剂结合在一起，可产生腐蚀性较低的混合物，并提供了一种无需机械破碎即可开孔的方法。
• Process for producing flexible polyurethane foam using natural oil polyols
  申请人：EVONIK DEGUSSA GMBH

  公开号：US10023678B2

  公开（公告）日：2018-07-17

  A composition and process useful to make flexible polyurethane foams and in particular flexible molded polyurethane foams is disclosed. The usage of dipolar aprotic liquids such as DMSO, DMI, sulfolane, N-methyl-acetoacetamide, N, N-dimethylacetoacetamide as well as glycols containing hydroxyl numbers OH#≤1100 as cell opening aides for 2-cyanoacetamide or other similar molecules containing active methylene or methine groups to make a polyurethane foam is also disclosed. The advantage of using cell opener aids results in a) no foam shrinkage; b) lower use levels of cell opener; c) foam performance reproducibility d) optimum physical properties. In addition, combining the acid blocked amine catalyst together with the cell opener and the cell opener aid results in a less corrosive mixture as well as provides a method that does not require mechanical crushing for cell opening.

  本发明公开了一种用于制造软质聚氨酯泡沫，特别是软质模塑聚氨酯泡沫的组合物和工艺。本发明还公开了使用二极性烷基液体，如二甲基亚砜、二甲基亚砜、N-甲基乙酰乙酰胺、N, N-二甲基乙酰乙酰胺以及含有羟基数 OH#≤1100 的乙二醇作为 2-氰基乙酰胺或其他含有活性亚甲基或甲基的类似分子的开孔助剂来制造聚氨酯泡沫。使用开孔助剂的优点是：a) 泡沫不会收缩；b) 开孔剂用量较少；c) 泡沫性能可再现；d) 物理性能最佳。此外，将酸性封端胺催化剂与开孔剂和开孔助剂结合在一起，可产生腐蚀性较低的混合物，并提供了一种无需机械破碎即可开孔的方法。
• Additives for improving polyurethane foam performance
  申请人：Evonik Degussa GmbH

  公开号：US10059823B2

  公开（公告）日：2018-08-28

  A composition and process useful to make flexible polyurethane foams and in particular flexible molded polyurethane foams is disclosed. The usage of dipolar aprotic liquids such as DMSO, DMI, sulfolane, N-methyl-acetoacetamide, N,N-dimethylacetoacetamide as well as glycols containing hydroxyl numbers OH#≤1100 as cell opening aides for 2-cyanoacetamide or other similar molecules containing active methylene or methine groups to make a polyurethane foam is also disclosed. The advantage of using cell opener aids results in a) no foam shrinkage; b) lower use levels of cell opener; c) foam performance reproducibility d) optimum physical properties. In addition, combining the acid blocked amine catalyst together with the cell opener and the cell opener aid results in a less corrosive mixture as well as provides a method that does not require mechanical crushing for cell opening.

  本发明公开了一种用于制造软质聚氨酯泡沫，特别是软质模塑聚氨酯泡沫的组合物和工艺。本发明还公开了使用二极性烷基液体，如二甲基亚砜、二甲基亚砜、N-甲基乙酰乙酰胺、N,N-二甲基乙酰乙酰胺以及含有羟基数 OH#≤1100 的乙二醇作为 2-氰基乙酰胺或其他含有活性亚甲基或甲基的类似分子的开孔助剂来制造聚氨酯泡沫。使用开孔助剂的优点是：a) 泡沫不会收缩；b) 开孔剂用量较少；c) 泡沫性能可再现；d) 物理性能最佳。此外，将酸性封端胺催化剂与开孔剂和开孔助剂结合在一起，可产生腐蚀性较低的混合物，并提供了一种无需机械破碎即可开孔的方法。
• Organic Syntheses with Anion Exchange Resins. I. The Malonic Ester Synthesis and Related Reactions
  作者：Kotaro Shimo、Shigeru Wakamatsu

  DOI：10.1021/jo01037a058

  日期：1963.2
• Solvent-Catalyzed Michael Reaction of Derivatives of Malonic and Cyanoacetic Acids with Acrylic Acid Derivatives in Liquid Ammonia
  作者：SHIGERU WAKAMATSU

  DOI：10.1021/jo01051a039

  日期：1962.4