2-(furan-2-yl)-2-[4-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxymethyl]triazol-1-yl]ethanol | 1225219-29-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: 2-(furan-2-yl)-2-[4-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxymethyl]triazol-1-yl]ethanol
• CAS: 1225219-29-3
• 化学式: C₂₁H₂₉N₃O₈
• 分子量: 451.477
• InChiKey: KBEHSSOVVDUERU-YZFOFTHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1,2:3,4-di-O-isopropylidene-6-O-(prop-2-ynyl)-α-D-galactopyranoside 、 D-葡萄烯糖 在 叠氮基三甲基硅烷 、 copper(II) bis(trifluoromethanesulfonate) 、 铜 作用下， 以 乙腈 为溶剂， 反应 7.83h， 以85%的产率得到2-(furan-2-yl)-2-[4-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxymethyl]triazol-1-yl]ethanol
  参考文献：
  名称：

  Multicomponent Cascade Transformation of d-Glucal to Furan-Appended Triazole Glycoconjugates

  摘要：

  Novel one-pot three- and four-component transformations of D-glucal to furan-based hydroxy triazole glycoconjugates have been achieved by sequential addition of reagents in the presence of Cu(OTf)(2)-Cu powder as catalysts. In general the carbohydrate-derived products were formed with high diastereomeric purity.

  DOI：

  10.1021/jo100475e

文献信息

• Cu–Mn bimetallic catalyst for Huisgen [3+2]-cycloaddition
  作者：Syed Khalid Yousuf、Debaraj Mukherjee、Baldev Singh、Sudip Maity、Subhash Chandra Taneja

  DOI：10.1039/c005088a

  日期：——

  Cu–Mn spinel oxide catalyst has been investigated for the ligand-free Huisgen [3+2] cycloaddition. The copper(I) species required in the cycloaddition reaction has been stabilized in the tetrahedral site of the spinel without the need of a stabilizing agent. The new catalyst is robust and can be reused several times under MW conditions with negligible loss in catalytic activity.

  铜锰尖晶石 氧化物 已针对无配体的Huisgen [3 + 2]对催化剂进行了研究 环加成。这铜（I） 所需的物种 环加成不需要稳定剂，反应已稳定在尖晶石的四面体部位。新的催化剂 具有很强的鲁棒性，可以在兆瓦特条件下重复使用几次，而损耗很小 催化活性。
• Multicomponent Cascade Transformation of <scp>d</scp>-Glucal to Furan-Appended Triazole Glycoconjugates
  作者：Syed Khalid Yousuf、Subhash Chandra Taneja、Debaraj Mukherjee

  DOI：10.1021/jo100475e

  日期：2010.5.7

  Novel one-pot three- and four-component transformations of D-glucal to furan-based hydroxy triazole glycoconjugates have been achieved by sequential addition of reagents in the presence of Cu(OTf)(2)-Cu powder as catalysts. In general the carbohydrate-derived products were formed with high diastereomeric purity.