(3S,4R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-[(2R,4S,6S)-2,4,6,7-tetrakis[[tert-butyl(dimethyl)silyl]oxy]heptyl]-1,3-dithian-2-yl]pentanal | 1306603-27-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: (3S,4R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-[(2R,4S,6S)-2,4,6,7-tetrakis[[tert-butyl(dimethyl)silyl]oxy]heptyl]-1,3-dithian-2-yl]pentanal
• CAS: 1306603-27-9
• 化学式: C₄₆H₁₀₀O₆S₂Si₅
• 分子量: 953.856
• InChiKey: KGLDCRXLZXREAT-CSISHVCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.53
• 重原子数：
  59
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (3S,4R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-[(2R,4S,6S)-2,4,6,7-tetrakis[[tert-butyl(dimethyl)silyl]oxy]heptyl]-1,3-dithian-2-yl]pentanal 在 pyridine hydrofluoride 、 lithium hexamethyldisilazane 作用下， 生成
  参考文献：
  名称：

  Synthesis of C1–C20 and C21–C40 fragments of tetrafibricin

  摘要：

  Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.086
• 作为产物：
  描述：

  (4R,2'R,3'S)-4-benzyl-3-[3-hydroxy-2-methylpent-4-enoyl]-oxazolidin-2-one 在 锂硼氢 、 叔丁基锂 、 三氧化硫吡啶 、 戴斯-马丁氧化剂 、 magnesium bromide ethyl etherate 、 9λ²-borabicyclo[3.3.1]nonane 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成 (3S,4R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-[(2R,4S,6S)-2,4,6,7-tetrakis[[tert-butyl(dimethyl)silyl]oxy]heptyl]-1,3-dithian-2-yl]pentanal
  参考文献：
  名称：

  Synthesis of C1–C20 and C21–C40 fragments of tetrafibricin

  摘要：

  Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.086

文献信息

• Synthesis of C1–C20 and C21–C40 fragments of tetrafibricin
  作者：Venugopal Gudipati、Dennis P. Curran

  DOI：10.1016/j.tetlet.2011.01.086

  日期：2011.4

  Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction. (C) 2011 Elsevier Ltd. All rights reserved.