二硫代丁酸甲酯 | 32931-10-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 中文名称: 二硫代丁酸甲酯
• 英文名称: methyl dithiobutanoate
• 英文别名: 1,1-bis-methylsulfanyl-butane；1,1-bis(methylthio)butane；Butyraldehyd-dimethylthioacetal；3-Propyl-2,4-dithiapentane；1,1-bis(methylsulfanyl)butane
• CAS: 32931-10-5
• 化学式: C₆H₁₄S₂
• 分子量: 150.309
• InChiKey: NOCYIUVTTOGLND-UHFFFAOYSA-N

物化性质

• 沸点：
  84 °C(Press: 13 Torr)
• 密度：
  0.964±0.06 g/cm3(Predicted)
• 保留指数：
  1124

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二硫代丁酸甲酯 在 磷酸 作用下， 生成 1-丁烯基甲基硫醚
  参考文献：
  名称：

  Hydrogenation of 1-alkyl(aryl)thio-1-buten-3-ynes over palladium catalyst

  摘要：

  DOI：

  10.1007/bf00862210
• 作为产物：
  描述：

  甲硫醇 、 正丁醛 在 盐酸 作用下， 生成 二硫代丁酸甲酯
  参考文献：
  名称：

  烤肉顶部空间的研究II。取代的2、4、5-三硫代己烷的合成†

  摘要：

  通过两种不同的途径合成了2、4、5-三硫代己烷1（最近在烤肉中发现的一类物质）。

  DOI：

  10.1002/hlca.19780610708

文献信息

• PROCESS FOR PREPARING a-KETO ACIDS AND DERIVATIVES THEREOF
  申请人：Kobler Christoph

  公开号：US20090076302A1

  公开（公告）日：2009-03-19

  A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.

  一种制备α-酮酸，特别是α-酮甲硫氨酸及/或其衍生物的方法，其中醛与硫醇反应形成相应的二硫缩醛，所形成的二硫缩醛在强碱存在下与亲电试剂反应，生成的α，α-(二硫)羧酸在酸催化下溶解产生硫醇并生成α-酮酸或其衍生物。通过与硫醇反应实现脂肪族或芳香族醛的Umpolung。
• Amino alcohol derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030236297A1

  公开（公告）日：2003-12-25

  Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: 1 wherein R 1 and R 2 are a hydrogen atom, an amino protecting group; R 3 is a hydrogen atom, a hydroxy protecting group; R 4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C 1 -C 10 alkylene group, a C 1 -C 10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R 5 is an aryl group; R 6 and R 7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R 5 is a hydrogen atom, Y is not a single bond or a straight chain C 1 -C 10 alkylene group.

  式（I）的化合物表现出优异的免疫抑制活性，其药理学上可接受的盐，酯或其他衍生物：其中R1和R2是氢原子，氨基保护基；R3是氢原子，羟基保护基；R4是较低的烷基基团；n是1到6之间的整数；X是乙烯基团；Y是C1-C10烷基基团，带有1到3个从取代基a和b中选择的取代基的C1-C10烷基基团；R5是芳基基团；R6和R7是氢原子，从取代基a中选择的基团；但是当R5是氢原子时，Y不是单键或直链的C1-C10烷基基团。
• DEOXYGENATIVE THIOACETALIZATION OF CARBONYL COMPOUNDS WITH ORGANIC DISULFIDE AND TRIBUTYLPHOSPHINE
  作者：Masato Tazaki、Makoto Takagi

  DOI：10.1246/cl.1979.767

  日期：1979.7.5

  A new deoxygenative thioether formation from carbonyl compounds as well as epoxides is presented (eq. 1–3). The reaction proceeds with the combined use of alkyl or aryl disulfide and tributylphosphine under neutral and mild conditions. The reaction with aldehydes proceeds with special ease to give thioacetals in high yields, and can be a valuable synthetic reaction.

  提出了一种由羰基化合物和环氧化物形成的新脱氧硫醚（方程式 1-3）。在中性和温和条件下，该反应在烷基或芳基二硫化物和三丁基膦的组合使用下进行。与醛的反应特别容易以高产率得到硫代缩醛，并且可以是有价值的合成反应。
• Amino alcohol derivatives or phosphonic acid derivatives and pharmaceutical compositions containing these
  申请人：Nishi Takahide

  公开号：US20050043386A1

  公开（公告）日：2005-02-24

  Amino alcohol compounds and phosphonic acid compounds having excellent immunosuppressive activity, pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising such compounds, the compounds having the following formula: wherein R 1 and R 2 each represent hydrogen, or a protecting group of the amino group; R 3 represents hydrogen, or a protecting group of the hydroxyl group; R 4 represents a lower alkyl group; n is 1 to 6; X represents oxygen or nitrogen, which is unsubstituted or substituted with a lower alkyl group; Y represents ethylene; Z represents a C 1 -C 10 alkylene; R 5 represents an aryl group; and R 6 and R 7 each represents hydrogen; provided that when R 5 represents hydrogen, then Z represents a group other than a single bond or a straight chain C 1 -C 10 alkylene group.

  具有出色的免疫抑制活性的氨基醇化合物和膦酸化合物，其药理学上可接受的盐和药理学上可接受的酯，以及包含这些化合物的制药组合物，其中化合物具有以下式子：其中R1和R2各代表氢，或氨基保护基；R3代表氢，或羟基保护基；R4代表较低的烷基；n为1至6；X代表氧或氮，未取代或取代为较低的烷基；Y代表乙烯；Z代表C1-C10烷基；R5代表芳基；R6和R7各代表氢；但是当R5代表氢时，Z代表除单键或直链C1-C10烷基组以外的一种基团。
• Amino alcohol compounds
  申请人：Nishi Takahide

  公开号：US20070105933A1

  公开（公告）日：2007-05-10

  A method for the preventing a disease selected from the group consisting of rheumatoid arthritis and psoriasis in a mammal, such as a human, in need thereof, which includes administering to the mammal a pharmaceutically effective amount of a compound of formula (Ia) wherein R 1 and R 2 are each hydrogen; R 3 is hydrogen; R 4 is C 1 -C 2 alkyl; n is 2; X is=N-D, wherein D is hydrogen, C 1 -C 4 alkyl or phenyl; Y is ethylene, ethynylene, —CO—CH 2 or phenylene; Z is ethylene or trimethylene; R 5 is an unsubstituted C 3 -C 10 cycloalkyl, an unsubstituted C 6 -C 10 aryl, or a C 3 -C 10 cycloalkyl or C 6 -C 10 aryl substituted with 1 to 3 substituents selected from the group consisting of halogen, lower alkyl, halogeno lower alkyl and lower alkoxy; and R 6 and R 7 are each hydrogen.

  本发明涉及一种用于预防哺乳动物，例如人类，需要预防风湿性关节炎和银屑病等疾病的方法，包括向哺乳动物内部给予化合物（Ia）的药物有效量，其中R1和R2均为氢; R3为氢; R4为C1-C2烷基; n为2; X为=N-D，其中D为氢、C1-C4烷基或苯基; Y为乙烯基、乙炔基、-CO-CH2或苯基; Z为乙烯基或三亚甲基; R5为未取代的C3-C10环烷基、未取代的C6-C10芳基或取代有1-3个取代基的C3-C10环烷基或C6-C10芳基，所述取代基选自卤素、低碳基、卤代低碳基和低烷氧基的群体; R6和R7均为氢。