2-溴-1-吡啶-2-基-乙醇 | 55967-97-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴-1-吡啶-2-基-乙醇
• 英文名称: 2-bromo-1-pyridin-2-yl-ethanol
• 英文别名: 2-bromo-1-(pyridin-2-yl)ethan-1-ol；2-Bromo-1-(2-pyridyl)-ethanol；2-bromo-1-pyridin-2-ylethanol
• CAS: 55967-97-0
• 化学式: C₇H₈BrNO
• 分子量: 202.051
• InChiKey: JAQYQJPRUALUJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-1-吡啶-2-基-乙醇 在 sodium azide 、 potassium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 生成 2-Azido-1-(pyridin-2-yl)ethan-1-ol
  参考文献：
  名称：

  Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

  摘要：

  Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E = 1-16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-beta-azido alcohols and (R)-alpha-azido alcohols (ee >= 99%) were obtained. (C) 2016 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2016.08.003
• 作为产物：
  描述：

  2-乙烯基吡啶 在 溶剂黄146 、 potassium bromide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 0.53h， 以16%的产率得到2-溴-1-吡啶-2-基-乙醇
  参考文献：
  名称：

  烯烃、溴化物和 ROH——如何实现选择性？溴醇及其醚的电化学合成

  摘要：

  溴醇及其醚是通过使用溴化钾和水或醇的烯烃的羟基和烷氧基溴化而电化学合成的。只有使用 DMSO 作为溶剂和酸作为添加剂才能实现溴醇形成的高选择性。尽管有多种副产物（环氧化物、二溴化物、二醇），所提议的起始试剂、添加剂和溶剂的组合允许选择性地形成溴醇或其醚。溴醇以高产率获得，高达 96%，在配备玻璃碳和高电流密度铂电极的未分割电化学电池中具有广泛的底物范围。

  DOI：

  10.1002/adsc.202100161

文献信息

• [EN] HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES D'HETEROARYL-ETHANOLAMINE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2004022567A1

  公开（公告）日：2004-03-18

  The present invention provides a compound of formula (I), which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种化合物(I)的公式，其作为抗病毒剂特别是抗疱疹病毒家族的药剂。
• NOVEL PROCESS TO PREPARE PIOGLITAZONE VIA SEVERAL NOVEL INTERMEDIATES
  申请人：Pandey Bipin

  公开号：US20140088127A1

  公开（公告）日：2014-03-27

  A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.

  一种制备噻唑烷二酮类药物的新工艺，首选为吡格列酮。还描述了参与其合成的新中间体，以及用于它们的制备和在医药中的应用的工艺。
• Novel process to prepare pioglitazone via several novel intermediates
  申请人：Pandey Bipin

  公开号：US20080300282A1

  公开（公告）日：2008-12-04

  A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.

  一种制备噻唑烷二酮的新工艺，优选为吡格列酮。同时还描述了参与其合成的新中间体，以及用于其制备和在医学上的应用的工艺。
• Imidazo[2,1-b]thiazole derivatives
  申请人：Rhone-Poulenc S.A.

  公开号：US04005212A1

  公开（公告）日：1977-01-25

  Imidazo[2,1-b]thiazoles carrying in the 2-position a phenyl radical unsubstituted or substituted by one or two atoms or radicals selected from halogen atoms and alkyl, alkoxy, alkylthio, dialkylamino, dialkylsulphamoyl, nitro, cyano and trifluoromethyl radicals or carrying in the 2-position a 2-, 3- or 4-pyridyl radical unsubstituted or substituted by an alkyl or alkoxy radical, are new compounds possessing pharmacological properties and useful, in particular, as anti-depressants and psycho-energisers.

  2-位置带有苯基自由基的咪唑并[2,1-b]噻唑，该苯基未被取代或被取代一个或两个来自卤素原子和烷基，烷氧基，烷基硫基，二烷基氨基，二烷基磺酰氨基，硝基，氰基和三氟甲基基团的原子或基团所选的新化合物，或2-位置带有未被取代或被取代一个烷基或烷氧基的2-，3-或4-吡啶基团的新化合物，具有药理学性质，特别是作为抗抑郁剂和精神兴奋剂有用。
• 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases
  作者：Mark E. Schnute、David J. Anderson、Roger J. Brideau、Fred L. Ciske、Sarah A. Collier、Michele M. Cudahy、MariJean Eggen、Michael J. Genin、Todd A. Hopkins、Thomas M. Judge、Euibong J. Kim、Mary L. Knechtel、Sajiv K. Nair、James A. Nieman、Nancee L. Oien、Allen Scott、Steven P. Tanis、Valerie A. Vaillancourt、Michael W. Wathen、Janet L. Wieber

  DOI：10.1016/j.bmcl.2007.03.102

  日期：2007.6

  A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.