2'-ethyl-3-methylflavone-8-carboxylic acid | 90102-15-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2'-ethyl-3-methylflavone-8-carboxylic acid
• 英文别名: 2-(2-Ethylphenyl)-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylic acid；2-(2-ethylphenyl)-3-methyl-4-oxochromene-8-carboxylic acid
• CAS: 90102-15-1
• 化学式: C₁₉H₁₆O₄
• 分子量: 308.334
• InChiKey: NQOANTGTLFWHTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-substituted flavone-8-carboxamides
  申请人：Hokuriku Pharmaceutical Co.,Ltd

  公开号：EP0108986A1

  公开（公告）日：1984-05-23

  Derivatives of N-substituted flavone-8-carboxamides represented by general formula (I) wherein R, represents a hydrogen atom, a methyl group or an ethyl group, R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a halogen atom or a nitro group, R3 represents a hydrogen atom or a lower alkyl group, k represents 0, 1, 2, or 3, m represents 0 or 1, X and Y, which must be different, represents a hydrogen atom or a methyl group, A represents an amino group having the wherein, R4 and R5, which may be the same or different, represent a lower alkyl group or a cyclic amino group together with the nitrogen atom and with or without an oxygen atom, R6 represents a lower alkyl group and n represents 2 or 3, are disclosed as well as pharmaceutical compositions thereof and method of treating therewith. The N-substituted flavone-8-carboxamides derivatives are useful as agents for treatment of dysurea.

  通式(I)代表的N-取代黄酮-8-羧酰胺的衍生物 其中，R 代表氢原子、甲基或乙基；R2 代表氢原子、低级烷基、低级烷氧基、卤素原子或硝基；R3 代表氢原子或低级烷基；k 代表 0、1、2 或 3；m 代表 0 或 1；X 和 Y（必须不同）代表氢原子或甲基；A 代表具有以下性质的氨基：(1)、(2)、(3)或(4)；(5)、(6)或(7)；(8)、(9)、(10)或(11)。 其中，R4 和 R5（可以相同或不同）代表低级烷基或环状氨基，与氮原子一起，有或没有氧原子，R6 代表低级烷基，n 代表 2 或 3，本发明公开了这些化合物及其药物组合物和处理方法。 N-取代的黄酮-8-羧酰胺衍生物可作为治疗尿失禁的药物。
• Methylflavone derivatives
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0100250A2

  公开（公告）日：1984-02-08

  The invention relates to 3-methylflavone derivatives represented by the general formula and salts thereof: as well as manufacture methods therefor and pharmaceutical agents containing them as main ingredient(s) wherein R1, R2 and R3 are same or different and are hydrogen, halogen, lower alkyl with one to ten main chain carbons, or lower alkoxy with one to four main chain carbons, R4 is hydroxyl, lower alkoxy with one to three main chain carbons, hydroxyalkyloxy with one to three main chain carbons or where R5 is hydrogen or lower alkyl with one to seven main chain carbons, R6 is lower alkyl with one to seven main chain carbons or cyclo alkyl with five to seven mumbers, the case where R5 and R6 are combined forming a five to seven memberedring is included,

  本发明涉及通式所代表的 3-甲基黄酮衍生物及其盐类： 以及其制造方法和含有它们作为主要成分的药剂 其中 R1、R2 和 R3 相同或不同，并且是氢、卤素、一至十个主链碳原子的低级烷基或一至四个主链碳原子的低级烷氧基，R4 是羟基、一至三个主链碳原子的低级烷氧基、一至三个主链碳原子的羟基烷氧基或 其中 R5 为氢或主链碳原子数为 1 至 7 的低级烷基，R6 为主链碳原子数为 1 至 7 的低级烷基或碳原子数为 5 至 7 的环烷基、
• US4525356A
  申请人：——

  公开号：US4525356A

  公开（公告）日：1985-06-25
• US4594345A
  申请人：——

  公开号：US4594345A

  公开（公告）日：1986-06-10