2,2'-(3,6-dioxa-octanediyl)-di-malonic acid tetraethyl ester | 78649-90-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2'-(3,6-dioxa-octanediyl)-di-malonic acid tetraethyl ester
• 英文别名: 2,2'-(3,6-Dioxa-octandiyl)-di-malonsaeure-tetraaethylester；Aethylenglykol-bis-(3.3-dicarbaethoxy-propyl)-aether；Diethyl 2-[2-[2-(4-ethoxy-3-ethoxycarbonyl-4-oxobutoxy)ethoxy]ethyl]propanedioate；diethyl 2-[2-[2-(4-ethoxy-3-ethoxycarbonyl-4-oxobutoxy)ethoxy]ethyl]propanedioate
• CAS: 78649-90-8
• 化学式: C₂₀H₃₄O₁₀
• 分子量: 434.484
• InChiKey: FXHHNYNCZYZBAI-UHFFFAOYSA-N

物化性质

• 沸点：
  484.6±45.0 °C(Predicted)
• 密度：
  1.125±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,2'-(3,6-dioxa-octanediyl)-di-malonic acid tetraethyl ester 在 Alkaline 、 水 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 1,4,10,13,19,22-Hexaoxa-cycloheptacosane-7,7,16,16,25,25-hexacarboxylic acid
  参考文献：
  名称：

  大环六羧酸。铀酰离子的高选择性宿主

  摘要：

  以前成功地制备了有效结合铀酰离子的大环六酮。最近，通过在大环骨架上对称排列六个羧酸盐来制备两种类型的大环六羧酸配体，其中调整环的大小以提供一个空腔以舒适地容纳铀酰离子。六个羧酸盐中的三个似乎构成了一个结合位点。两个配体中的三个额外羧酸单元之一可以连接到合适的聚合物载体上。另外两个可能起到使金属结合位点周围的微观环境更具亲水性以及减少络合中涉及的熵损失的作用。与之前的六酮相比，新的大环六羧酸能够以合理的总产率更容易地制备，并且对铀酰离子的结合更加有效和选择性。制备是正癸烷-1,1,-10,10-四羧酸四乙酯和..cap alpha..,..cap alpha..-双(8-碘辛基)丙二酸二乙酯之间的直接反应。在高稀释条件下实现环化，通过硅胶柱层析分离得到大环六羧酸六乙酯。碱水解产生六羧酸。类似的程序得到含有醚桥的六羧酸。铀酰离子是已知的 » 与碳酸盐 (CO/sub 3//sup 2 -/)

  DOI：

  10.1021/ja00538a060
• 作为产物：
  描述：

  三乙二醇 在 吡啶 、 乙醇 、 三溴化磷 作用下， 生成 2,2'-(3,6-dioxa-octanediyl)-di-malonic acid tetraethyl ester
  参考文献：
  名称：

  Rethinking the Analysis of Ethnic Residential Patterns: Segregation, Isolation, or Concentration Thresholds in Auckland, New Zealand?

  摘要：

  Data from the 1996 New Zealand Census on ethnicity in Auckland Urban Area are used to illustrate a new approach to measuring spatial separation. The traditionally employed single‐number indices are found wanting and a method based on thresholds is introduced. This provides more detailed information on the geography of ethnic groups that is consistent with the requirements for testing hypotheses regarding the relationship between social and spatial distance. The results show that (with a few exceptions) Polynesian groups were more encapsulated groups in Auckland than were Asian and European groups, and that most of the European groups—along with the “host society,” the New Zealand Europeans—were not spatially exposed to members of the Polynesian and Asian groups.

  DOI：

  10.1111/j.1538-4632.2002.tb01087.x

文献信息

• US4564690A
  申请人：——

  公开号：US4564690A

  公开（公告）日：1986-01-14
• Rethinking the Analysis of Ethnic Residential Patterns: Segregation, Isolation, or Concentration Thresholds in Auckland, New Zealand?
  作者：Ron Johnston、Michael Poulsen、Jantes Forrest

  DOI：10.1111/j.1538-4632.2002.tb01087.x

  日期：2002.7

  Data from the 1996 New Zealand Census on ethnicity in Auckland Urban Area are used to illustrate a new approach to measuring spatial separation. The traditionally employed single‐number indices are found wanting and a method based on thresholds is introduced. This provides more detailed information on the geography of ethnic groups that is consistent with the requirements for testing hypotheses regarding the relationship between social and spatial distance. The results show that (with a few exceptions) Polynesian groups were more encapsulated groups in Auckland than were Asian and European groups, and that most of the European groups—along with the “host society,” the New Zealand Europeans—were not spatially exposed to members of the Polynesian and Asian groups.
• Macrocyclic hexacarboxylic acid. A highly selective host for uranyl ion
  作者：Iwao Tabushi、Yoshiaki Kobuke、Kiyoto Ando、Masanari Kishimoto、Eiichi Ohara

  DOI：10.1021/ja00538a060

  日期：1980.8

  ether bridge. Uranyl ion is known tomore » form a stable complex with carbonate (CO/sub 3//sup 2 -/). High selectivity of these ligands to uranyl was ascertained also by competition with other metal cations such as: Na/sup +/, Mg/sup 2 +/, Ni/sup 2 +/, and Zn/sup 2 +/. These results indicate that uranyl ions can be extracted efficiently from sea water using these hexacarboxylic acid ligands which are attached

  以前成功地制备了有效结合铀酰离子的大环六酮。最近，通过在大环骨架上对称排列六个羧酸盐来制备两种类型的大环六羧酸配体，其中调整环的大小以提供一个空腔以舒适地容纳铀酰离子。六个羧酸盐中的三个似乎构成了一个结合位点。两个配体中的三个额外羧酸单元之一可以连接到合适的聚合物载体上。另外两个可能起到使金属结合位点周围的微观环境更具亲水性以及减少络合中涉及的熵损失的作用。与之前的六酮相比，新的大环六羧酸能够以合理的总产率更容易地制备，并且对铀酰离子的结合更加有效和选择性。制备是正癸烷-1,1,-10,10-四羧酸四乙酯和..cap alpha..,..cap alpha..-双(8-碘辛基)丙二酸二乙酯之间的直接反应。在高稀释条件下实现环化，通过硅胶柱层析分离得到大环六羧酸六乙酯。碱水解产生六羧酸。类似的程序得到含有醚桥的六羧酸。铀酰离子是已知的 » 与碳酸盐 (CO/sub 3//sup 2 -/)