N-tert-butyl-hydantoic acid | 86095-57-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tert-butyl-hydantoic acid
• 英文别名: 5-tert-butyl-hydantoic acid；N-tert-Butylcarbamoyl-glycin；5-tert-Butyl-hydantoinsaeure；2-(Tert-butylcarbamoylamino)acetic acid
• CAS: 86095-57-0
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: JDPGRKLCNPAWBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-噁唑烷二酮 、 叔丁胺 在 二氯甲烷 作用下， 生成 N-tert-butyl-hydantoic acid
  参考文献：
  名称：

  The Reaction of Amines with Amino Acid N-Carboxy Anhydrides

  摘要：

  DOI：

  10.1021/ja01560a041

文献信息

• [EN] PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R, 2S, 5S)-3-AZABICYCLO[3, 1, 0]HEXANE-2-CARBOXAMIDE, N-[3-AMINO-1-(CYCLOBUTYLMETHYL)-2, 3-DIOXOPROPYL] ]-3-[(2S)-2-[[[1, 1-DIMETHYLETHYL]AMINO]CARBONYLAMINO]-3, 3-DIMETHYL-1-OXOBUTYL]-6, 6-DIMETHYL<br/>[FR] PROCEDE ET INTERMEDIAIRES POUR PREPARER DU (1R,2S,5S)-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXAMIDE, N-[3-AMINO-1-(CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]-3-[(2S)-2-[[[1,1-DIMETHYLETHYL]AMINO]CARBONYLAMINO]-3,3-DIMETHYL-1-OXOBUTYL]-6,6-DIMETHYLE
  申请人：SCHERING CORP

  公开号：WO2004113294A1

  公开（公告）日：2004-12-29

  In one embodiment, the present application relates to a process of making a compound of formula (I): and to certain intermediate compounds that are made within the process of making the compound of formula (I).

  在一个实施例中，本申请涉及制备化合物(I)的过程，以及在制备化合物(I)过程中制备的某些中间化合物。
• [EN] PROCESS FOR THE PREPARATION OF (3S)-3-AMINO-N-CYCLOPROPYL-2-HYDROXYALKANAMIDE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE (3S)-3-AMINO-N-CYCLOPROPYL-2-HYDROXYALCANAMIDE
  申请人：VIROBAY INC

  公开号：WO2009114633A1

  公开（公告）日：2009-09-17

  The present invention relates to a process for the preparation of (2S,3S)-3-amino-N- cyclopropyl-2-hydroxyalkanamides, and their use in the preparation of HCV inhibitors and cathepsin inhibitors.

  本发明涉及一种制备（2S,3S）-3-氨基-N-环丙基-2-羟基脂肪酰胺的方法，以及它们在制备HCV抑制剂和卡特普星抑制剂中的应用。
• PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R, 2S, 5S)-3- AZABICYCLO[ 3, 1, 0]HEXANE-2-CARBOXAMIDE, N- [3-AMINO -1-(CYCLOBUTYLMETHYL)-2, 3-DIOXOPROPYL] ]-3- [ (2S)- 2-[[[1, 1-DIMETHYLETHYL ]AMINO]CARBONYLA MINO ]-3, 3-DIMETHYL-1-OXOBUTYL] -6, 6-DIMETHYL
  申请人：Schering Corporation

  公开号：EP1641754B1

  公开（公告）日：2008-03-26
• MOSTOWICZ, D.;ABRAMSKI, W.;BELZECKI, C., POL. J. CHEM., 1981, 55, N 6, 1387-1391
  作者：MOSTOWICZ, D.、ABRAMSKI, W.、BELZECKI, C.

  DOI：——

  日期：——
• [EN] ASSOCIATION OF COMPOUNDS IN CARBON DIOXIDE AND THE GELS AND/OR FOAMS FORMED THEREFROM<br/>[FR] ASSOCIATION DE COMPOSES AU GAZ CARBONIQUE, GELS ET/OU MOUSSES AINSI OBTENUS
  申请人：UNIV YALE

  公开号：WO2000035998A2

  公开（公告）日：2000-06-22

  The invention relates to a method of increasing the viscosity of supercritical CO2 by combining a compound having a CO2-philic functional group and an aggregating functional group which enables the compound to form a supramolecular network in solution with supercritical CO2 to form a solution. The compound is then aggregated in solution to form a supramolecular network such that the viscosity of the supercritical CO2 with the supramolecular network is greater than that of the starting supercritical CO2. The invention also relates to a method of making a microcellular foam by combining a compound having a CO2-philic functional group and an aggregating functional group which enables the compound to form a supramolecular network in solution, with supercritical CO2 to form a solution. The compound is aggregated to form a supramolecular network in solution. Then the CO2 is removed under conditions sufficient to form a microcellular foam.