3,8-dibromo-1,10-diphenyl-1,9-decadiyne | 303142-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,8-dibromo-1,10-diphenyl-1,9-decadiyne
• 英文别名: (3,8-Dibromo-10-phenyldeca-1,9-diynyl)benzene；(3,8-dibromo-10-phenyldeca-1,9-diynyl)benzene
• CAS: 303142-54-3
• 化学式: C₂₂H₂₀Br₂
• 分子量: 444.209
• InChiKey: IXHIQBZBPNGCQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3,8-dibromo-1,10-diphenyl-1,9-decadiyne 在 六甲基磷酰三胺 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以94%的产率得到(cyclohexene-1,2-diyl-bisethynyl)-bisbenzene
  参考文献：
  名称：

  Synthesis and Protein Degradation Capacity of Photoactivated Enediynes

  摘要：

  The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.

  DOI：

  10.1021/jo051403q
• 作为产物：
  描述：

  己二酰氯 在 2,6-二甲基吡啶 、 manganese(II) iodide 、 sodium tetrahydroborate 、 正丁基锂 、 溴 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 3,8-dibromo-1,10-diphenyl-1,9-decadiyne
  参考文献：
  名称：

  Synthesis and Protein Degradation Capacity of Photoactivated Enediynes

  摘要：

  The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.

  DOI：

  10.1021/jo051403q

文献信息

• Synthesis and Photochemical Activity of Designed Enediynes
  作者：Graham B. Jones、Justin M. Wright、Gary Plourde、Ajay D. Purohit、Justin K. Wyatt、George Hynd、Farid Fouad

  DOI：10.1021/ja000766z

  日期：2000.10.1
• Synthesis and Protein Degradation Capacity of Photoactivated Enediynes
  作者：Farid S. Fouad、Justin M. Wright、Gary Plourde II,、Ajay D. Purohit、Justin K. Wyatt、Ahmed El-Shafey、George Hynd、Curtis F. Crasto、Yiqing Lin、Graham B. Jones

  DOI：10.1021/jo051403q

  日期：2005.11.1

  The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.