1-[(2-Methylbutan-2-YL)disulfanyl]octane | 663622-76-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: 1-[(2-Methylbutan-2-YL)disulfanyl]octane
• 英文别名: 1-(2-methylbutan-2-yldisulfanyl)octane
• CAS: 663622-76-2
• 化学式: C₁₃H₂₈S₂
• 分子量: 248.497
• InChiKey: UZPHYYFUSKJHGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基-2-丁硫醇 、 1-辛硫醇 在 bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以75%的产率得到二正辛基二硫
  参考文献：
  名称：

  Cationic rhodium(I)/PPh3 complex-catalyzed dehydrogenation of alkanethiols to disulfides under inert atmosphere

  摘要：

  A cationic rhodium(I)/PPh3 complex is an effective catalyst for dehydrogenation of primary or secondary alkanethiols to symmetrical disulfides under inert atmosphere. The dependence of reactivity on the structure of thiols is examined in detail. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.120

文献信息

• [EN] POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS<br/>[FR] CONSTRUCTIONS POLYNUCLÉOTIDIQUES CONTENANT DES GROUPES DISULFURE
  申请人：SOLSTICE BIOLOG LTD

  公开号：WO2015069932A1

  公开（公告）日：2015-05-14

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internudeotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  该发明涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）包含靠近二硫键的一个或多个臃肿基团。该发明还涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分（i）连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）在二硫键和核苷酸桥连基团或末端基团的磷原子之间的链中至少包含4个原子；并且该链不包含磷酸酯、酰胺、酯或烯基烃。该发明还涉及使用该发明的聚核苷酸构造将聚核苷酸传递到细胞的方法。
• Cationic rhodium(I)/PPh3 complex-catalyzed dehydrogenation of alkanethiols to disulfides under inert atmosphere
  作者：Ken Tanaka、Kaori Ajiki

  DOI：10.1016/j.tetlet.2003.10.120

  日期：2004.1

  A cationic rhodium(I)/PPh3 complex is an effective catalyst for dehydrogenation of primary or secondary alkanethiols to symmetrical disulfides under inert atmosphere. The dependence of reactivity on the structure of thiols is examined in detail. (C) 2003 Elsevier Ltd. All rights reserved.