5,6-dichloro-2-(3-bromobenzyl)-1H-benzimidazole | 1550694-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5,6-dichloro-2-(3-bromobenzyl)-1H-benzimidazole
• 英文别名: 2-[(3-bromophenyl)methyl]-5,6-dichloro-1H-benzimidazole
• CAS: 1550694-26-2
• 化学式: C₁₄H₉BrCl₂N₂
• 分子量: 356.049
• InChiKey: ZEBMDFLTLFKMEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5,6-dichloro-2-(3-bromobenzyl)-1H-benzimidazole 在 potassium carbonate 、 一水合肼 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 0.2h， 生成 2-[5,6-dichloro-2-(3-bromobenzyl)-1H-benzimidazole-1-yl]acetohydrazide
  参考文献：
  名称：

  Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

  摘要：

  A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.

  DOI：

  10.3109/14756366.2012.753880
• 作为产物：
  描述：

  4,5-二氯邻苯二胺 、 Ethyl 2-(3-bromophenyl)ethanimidate;hydrochloride 以 甲醇 为溶剂， 反应 0.17h， 以91%的产率得到5,6-dichloro-2-(3-bromobenzyl)-1H-benzimidazole
  参考文献：
  名称：

  Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

  摘要：

  A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.

  DOI：

  10.3109/14756366.2012.753880

文献信息

• Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity
  作者：Emre Menteşe、Hakan Bektaş、Serdar Ülker、Olcay Bekircan、Bahittin Kahveci

  DOI：10.3109/14756366.2012.753880

  日期：2014.2.1

  A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.