Ethyl 2-(3-bromophenyl)ethanimidate;hydrochloride | 1446340-74-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-(3-bromophenyl)ethanimidate;hydrochloride
• 英文别名: ethyl 2-(3-bromophenyl)ethanimidate;hydrochloride
• CAS: 1446340-74-4
• 化学式: C₁₀H₁₂BrNO*ClH
• 分子量: 278.576
• InChiKey: BTOCFDUGXAIXBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Ethyl 2-(3-bromophenyl)ethanimidate;hydrochloride 在 potassium carbonate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 0.29h， 生成 methyl [5,6-dichloro-2-(3-bromobenzyl)-1H-benzimidazole-1-yl]acetate
  参考文献：
  名称：

  Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

  摘要：

  A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.

  DOI：

  10.3109/14756366.2012.753880
• 作为产物：
  描述：

  乙醇 、 3-溴氰苄 在 盐酸 作用下， 生成 Ethyl 2-(3-bromophenyl)ethanimidate;hydrochloride
  参考文献：
  名称：

  Efficient Microwave Assisted Synthesis of Some New Benzimidazoles Containing the Mebendazole Nucleus

  摘要：

  我们开发了一种简单实用的方法来合成含有生物活性甲苯咪唑核的苯并咪唑。在微波辐照下，苯乙酸的氨基酯盐酸盐被用作与 3,4-二氨基二苯甲酮反应的中间体，从而以良好的收率和较短的反应时间得到产物。

  DOI：

  10.3184/174751913x13603595770952

文献信息

• Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives
  作者：E. Menteşe、F. Yılmaz、N. Karaali、S. Ülker、B. Kahveci

  DOI：10.1134/s1068162014030091

  日期：2014.5

  This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H NMR and 13C NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with

  本研究通过微波技术合成了一些新系列的苯并咪唑、双苯并咪唑和哌啶衍生物，具有良好的产品收率和较短的反应时间。新合成化合物的结构经 1H NMR 和 13C NMR 谱证实。筛选这些化合物的脂肪酶抑制活性。然后，评估所有化合物的胰脂肪酶活性，并且一些 2-取代的双嘧啶、双嘧啶和双苯并咪唑衍生物在不同浓度下显示出脂肪酶抑制作用。
• Efficient Microwave Assisted Synthesis of Some New Benzimidazoles Containing the Mebendazole Nucleus
  作者：Emre Menteşe

  DOI：10.3184/174751913x13603595770952

  日期：2013.3

  A simple and practical method has been developed for the synthesis of benzimidazoles containing the biological active mebendazole nucleus. Iminoester hydrochlorides of phenylacetic acids were used as intermediates in the reaction with 3,4-diaminobenzophenone under microwave irradiation leading to the products in good yields and in short reaction times.

  我们开发了一种简单实用的方法来合成含有生物活性甲苯咪唑核的苯并咪唑。在微波辐照下，苯乙酸的氨基酯盐酸盐被用作与 3,4-二氨基二苯甲酮反应的中间体，从而以良好的收率和较短的反应时间得到产物。
• Rapid and Efficient Synthesis of a New Series of 2-Aryl-5-Fluoro-6-(4-Phenylpiperazin-1-Yl)-1H-Benzimidazoles Using Microwave Heating
  作者：Emre Menteşe、Fatih Yılmaz、Fatih İslamoğlu、Bahittin Kahveci

  DOI：10.3184/174751915x14268750943001

  日期：2015.4

  iminoester hydrochlorides. 4-Fluoro-5-(4-phenylpiperazin-1-yl)benzene-1,2-diamine was prepared from the reduction of 5-fluoro-2-nitro-4-(4-phenylpiperazin-1-yl)aniline by using Pd/C (10%) catalyst and hydrazine hydrate under microwave irradiation. The structures of newly synthesised compounds were identified by 1H NMR, 13C NMR, mass spectroscopy and elemental analysis data.

  由4-氟-5-(4-苯基哌嗪-1-基)苯反应合成了一系列新的2-芳基-5-氟-6-(4-苯基哌嗪-1-基)-1H-苯并咪唑- 1,2-二胺和亚氨基酯盐酸盐。4-氟-5-(4-苯基哌嗪-1-基)苯-1,2-二胺是由5-氟-2-硝基-4-(4-苯基哌嗪-1-基)苯胺还原制备的微波辐射下的 Pd/C (10%) 催化剂和水合肼。新合成化合物的结构通过1H NMR、13C NMR、质谱和元素分析数据进行鉴定。
• Synthesis of New Perimidine Derivatives from the Reaction of 1,8-Diaminonapthalene with Iminoester Hydrochlorides
  作者：Bahittin Kahveci、Nesrin Karaali、Emre Menteşe、Fatih Yilmaz

  DOI：10.3184/174751913x13691578103477

  日期：2013.6

  procedure is described for the synthesis of 2-substituted perimidines involving the reaction of 1,8-diaminonapthalene with iminoester hydrochlorides of substituted phenylacetic acids under microwave irradiation. This leads to good yields in short reaction times. The results were compared with those that used conventional heating. This new method may be preferable for the synthesis of perimidines.

  描述了一种用于合成 2-取代的 perimidines 的替代程序, 包括 1,8-二氨基萘与取代苯乙酸的亚氨基酯盐酸盐在微波辐射下的反应。这导致在较短的反应时间内获得良好的产率。将结果与使用传统加热的结果进行比较。这种新方法可能更适用于合成嘧啶。
• Mentese, Emre; Kahveci, Bahittin, Revue Roumaine de Chimie, 2014, vol. 59, # 2, p. 147 - 150
  作者：Mentese, Emre、Kahveci, Bahittin

  DOI：——

  日期：——