(L)-2,3-diaminopropionic acid methyl ester dihydrochloride | 6059-44-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (L)-2,3-diaminopropionic acid methyl ester dihydrochloride
• 英文别名: (S)-methyl 2,3-diaminopropanoate dihydrochloride；methyl 2(S),3-diaminopriopionate dihydrochloride；(S)-2,3-diamino-propionic acid methyl ester; dihydrochloride；(S)-2,3-Diamino-propionsaeure-methylester; Dihydrochlorid；Methyl 2(S),3-diaminopropionate hydrochloride；methyl (2S)-2,3-diaminopropanoate;hydrochloride
• CAS: 6059-44-5；106973-48-2；147857-43-0
• 化学式: C₄H₁₀N₂O₂*2ClH
• 分子量: 191.057
• InChiKey: IQEZFJIELCEIAX-DFWYDOINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.13
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 (L)-2,3-diaminopropionic acid methyl ester dihydrochloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以53%的产率得到L-3-N-Boc-2,3-二氨基丙酸甲酯
  参考文献：
  名称：

  [EN] LABELLED COMPOUNDS THAT BIND TO ALPHA-V-BETA-3 INTEGRIN
  [FR] COMPOSÉS MARQUÉS QUI SE LIENT À L'INTÉGRINE ALPHA V BÊTA 3

  摘要：

  本发明涉及体内成像，特别是一种具有化学式（I）的新型体内成像剂。本发明还提供了一种用于制备所述体内成像剂的方法，以及在该方法中有用的前体化合物。本发明的体内成像剂在诊断表达整合素αvβ3异常的疾病情况方面具有用途。

  公开号：

  WO2014122228A1
• 作为产物：
  描述：

  N-β-叔丁氧羰基-L-Alpha,β-二氨基丙酸甲酯盐酸盐 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以99 %的产率得到(L)-2,3-diaminopropionic acid methyl ester dihydrochloride
  参考文献：
  名称：

  METHOD FOR INDUCING ENVIRONMENTAL STRESS TOLERANCE IN PLANTS

  摘要：

  A technique for inducing tolerance to environmental stress in a plant is provided. Tolerance to environmental stress in a plant is induced by applying to the plant an abscisic acid-like substance, such as abscisic acid and agonists thereof, in combination with a nitrogen-containing compound, such as amino acids and amino acid derivatives.

  公开号：

  US20230210110A1

文献信息

• Compounds and methods for identifying activated platelets
  申请人：Merck & Co., Inc.

  公开号：US05646000A1

  公开（公告）日：1997-07-08

  The invention is directed to a series of novel compounds, and their pharmaceutically acceptable salts, of the formula ##STR1## wherein R is C.sub.0-6 alkyl substituted with R.sup.5 or a mono or polycyclic aromatic or heteroaromatic system comprised of 5 or 6-membered aromatic or heteroaromatic rings that are either unsubstituted or substituted with one or more of R.sup.1 and R.sup.2 ; R.sup.1 and R.sup.2 are independently C.sub.1-6 alkyl, carboxyl, hydroxyl, azido, nitro, amino, C.sub.1-6 alkylamino, C.sub.1-6 dialkylamino, arylamino, aryl C.sub.1-6 alkylamino, hydroxysulfonyl or arylazo; aryl is a phenyl or naphthyl ring which is unsubstituted or substituted with one or more of R.sup.3 and R.sup.4 ; R.sup.3 and R.sup.4 are independently C.sub.1-6 alkyl, azido, nitro, amino, C.sub.1-6 dialkylamino or hydroxysulfonyl; R.sup.5 is ##STR2## provided that when R is an unsubstituted monocyclic ring, the monocyclic ring is not phenyl or pyridyl. Such compounds are useful as fluorescent probes for identifying antiplatelet agents which selectively bind to activated platelets.

  该发明涉及一系列新颖化合物及其药用可接受的盐，其化学式为##STR1##其中R是C.sub.0-6烷基，被R.sup.5取代，或者是一个由5个或6个芳香环或杂芳环组成的单环或多环芳香体系，这些环要么未取代，要么被一个或多个R.sup.1和R.sup.2取代；R.sup.1和R.sup.2独立地是C.sub.1-6烷基，羧基，羟基，叠氮基，硝基，氨基，C.sub.1-6烷基氨基，C.sub.1-6二烷基氨基，芳基氨基，芳基C.sub.1-6烷基氨基，羟基磺酰基或芳基偶氮基；芳基是一个未取代或被一个或多个R.sup.3和R.sup.4取代的苯环或萘环；R.sup.3和R.sup.4独立地是C.sub.1-6烷基，叠氮基，硝基，氨基，C.sub.1-6二烷基氨基或羟基磺酰基；R.sup.5是##STR2##但是当R是一个未取代的单环时，该单环不是苯基或吡啶基。这些化合物可用作荧光探针，用于鉴定选择性结合到活化血小板的抗血小板药物。
• Synthesis and Antibacterial Activities of Yanglingmycin Analogues
  作者：Long-Bo Li、Wen-Jia Dan、Fang-Fang Tan、Li-Hui Cui、Zhi-Peng Yuan、Wen-Jun Wu、Ji-Wen Zhang

  DOI：10.1248/cpb.c14-00578

  日期：——

  The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 µg/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides.

  报告了阳灵霉素及其对映体，以及十八种阳灵霉素类药物的合成。其结构主要通过核磁共振(NMR)光谱数据的分析得以确认。抗菌活性测定表明，阳灵霉素及其部分类药物对两种重要的农业病原菌——苏云金芽孢杆菌（Ralstonia solanacearum）和青枯病细菌（Pseudomonas syringae pv. actinidiae）具有显著的抗菌活性，最低抑菌浓度（MIC）值范围为3.91至15.62 µg/mL。阳灵霉素及其类药物表现出的抗菌活性具有潜力，建议在新型杀菌剂的化合物开发中具有应用前景。
• [EN] LABELLED COMPOUNDS THAT BIND TO ALPHA-V-BETA-3 INTEGRIN<br/>[FR] COMPOSÉS MARQUÉS QUI SE LIENT À L'INTÉGRINE ALPHA V BÊTA 3
  申请人：UNIV MUENSTER WILHELMS

  公开号：WO2014122228A1

  公开（公告）日：2014-08-14

  The present invention concerns in vivo imaging and in particular a novel in vivo imaging agent of formula (I). Also provided by the present invention is a method for the preparation of the in vivo imaging agent of the invention, and precursor compounds useful in said method. The in vivo imaging agent of the invention is useful in the diagnosis of conditions where there is a deviation from normal in the expression of integrin αvβ3.

  本发明涉及体内成像，特别是一种具有化学式（I）的新型体内成像剂。本发明还提供了一种用于制备所述体内成像剂的方法，以及在该方法中有用的前体化合物。本发明的体内成像剂在诊断表达整合素αvβ3异常的疾病情况方面具有用途。
• A Selective Protection of 2,3-Diaminopropionic Acid
  作者：M. S. Egbertson、C. F. Homnick、G. D. Hartman

  DOI：10.1080/00397919308009829

  日期：1993.3.1

  A two step selective protection of 2,3-diaminopropionic acid yields the useful diaminopropionic acid methyl ester 3a. Further manipulation yields 2(S)-(N-benzyloxycarbonylamino)-3-aminopropionic acid methyl ester hydrochloride 5 in >99.9%ee.
• [EN] INHIBITORS OF MICROBIALLY INDUCED AMYLOID<br/>[FR] INHIBITEURS D'AMYLOÏDE INDUITE PAR VOIE MICROBIENNE
  申请人：AXIAL THERAPEUTICS INC

  公开号：WO2021142333A3

  公开（公告）日：2021-08-19