1,2-bis(anisylphenylphosphino)ethane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2-bis(anisylphenylphosphino)ethane
• 英文别名: (4-Methoxyphenyl)methyl-[2-[(4-methoxyphenyl)methyl-phenylphosphanyl]ethyl]-phenylphosphane；(4-methoxyphenyl)methyl-[2-[(4-methoxyphenyl)methyl-phenylphosphanyl]ethyl]-phenylphosphane
• 化学式: C₃₀H₃₂O₂P₂
• 分子量: 486.53
• InChiKey: HOUVMANXMAALNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-双(苯基膦酰)乙烷 、 4-甲氧基溴苄 在 Pt((R,R)-Me-DuPhos)(Ph)(Cl) sodium trimethylsilanolate 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 1,2-bis(anisylphenylphosphino)ethane 、 1,2-bis((4-methoxybenzyl)(phenyl)phosphaneyl)ethane
  参考文献：
  名称：

  WO2007/16264

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING ALCOHOL COMPOUND
  申请人：Shimizu Hideo

  公开号：US20110201819A1

  公开（公告）日：2011-08-18

  Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.

  本文揭示了一种实用的方法，通过使用易获得的低成本金属种类——均相铜催化剂，通过氢化醛类化合物高效产生醇类化合物。具体揭示了一种产生醇类化合物的方法，其特点在于在均相铜催化剂和二膦化合物存在下进行醛类化合物的氢化反应。
• Homogeneous asymmetric hydrogenation catalyst
  申请人：Shimizu Hideo

  公开号：US20090203927A1

  公开（公告）日：2009-08-13

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种用于均相氢化的有用催化剂，特别是用于均相不对称氢化的催化剂，特别是不对称氢化的催化剂，该催化剂易于获得，在经济性和可操作性方面表现出色，以及一种使用该催化剂产生不饱和化合物的氢化物的方法，特别是使用高产率和光学纯度的该催化剂产生手性活性化合物。
• [EN] PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED BETA AMINO ACID DERIVATIVES<br/>[FR] PROCEDE POUR LA PREPARATION DE DERIVES D'ACIDES AMINES BETA A ENRICHISSEMENT ENANTIOMERIQUE
  申请人：MERCK & CO INC

  公开号：WO2005097733A1

  公开（公告）日：2005-10-20

  The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

  本发明涉及一种高效制备对映富集的β-氨基酸衍生物的过程，其中氨基未受保护。所得的手性β-氨基酸衍生物在生物活性分子的不对称合成中很有用。该过程包括在铑金属前体与手性单膦或双膦配体络合物的存在下对氨基未受保护的丙烯酸β-氨基或其衍生物进行对映选择性的氢化。
• Optically Active a-Trifluoromethyl-B-Amino Acid Derivative Production Method
  申请人：MICROBIAL CHEMISTRY RESEARCH FOUNDATION

  公开号：US20170283411A1

  公开（公告）日：2017-10-05

  A method for producing an optically active α-trifluoromethyl-β-amino acid derivative, the method including: allowing a compound represented by the following General Formula (1) and a compound represented by the following General Formula (2) to react in the presence of a copper-optically active phosphine complex obtained from a copper compound and an optically active phosphine compound, to thereby obtain an optically active α-trifluoromethyl-β-amino acid derivative represented by the following General Formula (3):

  一种制备光学活性α-三氟甲基-β-氨基酸衍生物的方法，该方法包括：在存在铜化合物和光学活性膦化合物得到的铜-光学活性膦配合物的情况下，使下列通式（1）所代表的化合物和下列通式（2）所代表的化合物反应，从而得到下列通式（3）所代表的光学活性α-三氟甲基-β-氨基酸衍生物。
• MANUFACTURING METHOD OF ORGANOBORON COMPOUND
  申请人：SAWAMURA Masaya

  公开号：US20080262257A1

  公开（公告）日：2008-10-23

  A manufacturing method for one of, or a mixture of, an optically active allylboron compound and racemic or optically active boryl cyclopropane, including a coupling reaction, in the presence of a catalyst, between allyl compound and diboron compound. It is preferred that a copper (I) complex is used as the catalyst. It is preferred that a counterion of the copper (I) complex is an alkoxide or a hydride. It is preferred that the copper (I) complex has a phosphine ligand. It is preferred that the phosphine ligand is a chiral phosphine ligand.

  一种制备手性烯丙基硼化合物和外消旋或手性的硼代环丙烷混合物的方法，包括在催化剂存在下，烯丙基化合物和二硼化合物之间的偶联反应。最好使用铜(I)配合物作为催化剂。最好铜(I)配合物的反离子是醇盐或氢化物。最好铜(I)配合物具有膦配体。最好膦配体是手性膦配体。