4-pentylimidazole | 110453-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-pentylimidazole
• 英文别名: 4-pentyl-1(3)H-imidazole；4-Pentyl-1(3)H-imidazol；5-pentyl-1H-imidazole
• CAS: 110453-29-7
• 化学式: C₈H₁₄N₂
• mdl: MFCD20617820
• 分子量: 138.213
• InChiKey: QTNOWIJWHWQTTF-UHFFFAOYSA-N

物化性质

• 熔点：
  44-46 °C
• 沸点：
  188-188.5 °C(Press: 16 Torr)
• 密度：
  0.964±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-(n-pentyl)-4-tosyl-2-oxazoline 在 氨 作用下， 以 乙醇 为溶剂， 反应 25.0h， 生成 4-pentylimidazole
  参考文献：
  名称：

  Synthesis and histamine H3 receptor activity of 4-(n-alkyl)-1H-imidazoles and 4-(ω-phenylalkyl)-1H-imidazoles

  摘要：

  The influence of lipophilic moieties attached to a 4-1H-imidazole ring on the histamine H-3 receptor activity was systematically investigated. Series of 4-(n-alkyl)-1H-imidazoles and 4-(omega-phenylalkyl)-1H-imidazoles were prepared, with an alkyl chain varying from 2-9 methylene groups and from 1-9 methylene groups, respectively. The compounds were tested for their activity on the H-3 receptor under in vitro conditions. For the 4-(n-alkyl)-1H-imidazoles the activity is proportional to chain length, ranging from a pA(2) value of 6.3 +/- 0.2 for 4-(n-propyl)-1H-imidazoIe to a pA(2) value of 7.2 +/- 0.1 for 4-(n-decyl)-1H-imidazole. For the series 4-(omega-phenylalkyl)-4H-imidazoles an optimum in H-3 activity was found for the pentylene spacer: 4-(omega-phenylpentyl)-1H-imidazole has a pA(2) value of 7.8 +/- 0.1. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00253-9

文献信息

• Enantioselective N-heterocyclic carbene-catalyzed annulation reactions with imidazolidinones
  申请人：Scheidt Karl A.

  公开号：US20140206886A1

  公开（公告）日：2014-07-24

  Enantiomeric bicyclic lactone compounds as can be prepared via an N-heterocyclic carbene-catalyzed annulation reaction.

  通过N-杂环卡宾催化的环加成反应可以制备对映异构的双环内酯化合物。
• [EN] AROMATIC IMIDAZOLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES OF BACTERIAL NATURE<br/>[FR] DÉRIVÉS D'IMIDAZOLIDINONES AROMATIQUES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES DE NATURE BACTÉRIENNE
  申请人：UNIV JAGIELLONSKI

  公开号：WO2013151450A1

  公开（公告）日：2013-10-10

  The invention introduces new derivatives of aromatic imidazolidinones, which fall within the scope of the general formula I and their pharmaceutical forms of suitable additive salts with acids, wherein R1 and R2 are as defined herein, in particular for the prevention or treatment of diseases of bacterial nature. The invention further introduces the use of compounds according to the invention for the manufacture of a medication useful for the treatment of various conditions as described above.

  该发明介绍了芳香基咪唑烷酮的新衍生物，其属于一般式I范围内，以及它们与酸适当添加盐的药用形式，其中R1和R2如本文所定义，特别用于预防或治疗细菌性疾病。该发明进一步介绍了根据该发明的化合物用于制造用于治疗上述各种疾病的药物的用途。
• Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
  申请人：Gregor Vlad E.

  公开号：US20080171769A1

  公开（公告）日：2008-07-17

  Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.

  提供的是化合物的结构式(I)：或其立体异构体、互变异构体、盐、水合物或前药，这些化合物调节酪氨酸激酶活性，包括这些化合物的组合物以及它们的使用方法。
• Compounds of the family of 3-alkyl-(4,5-diphenyl-imidazol-1-yl) and their use as soothing agents
  申请人：——

  公开号：US20040162328A1

  公开（公告）日：2004-08-19

  The invention concerns novel compounds of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), their synthesis method and cosmetic, hygienic or pharmaceutical compositions containing them The invention also concerns the use, in a physiologically acceptable medium, in or for preparing a soothing composition, of at least a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl). The invention further concerns the use, in a physiologically acceptable medium, in or for preparing a composition, a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), the compound and the composition being designed for soothing skin troubles such as sensitive skins, discomfort, gnawing, itching, irritations, red spots, heat and/or flush sensations, advantageously sensitive and/or irritable and/or reactive and/or allergic symptoms of the skin and/or the scalp and/or mucosa. Finally, the invention concerns a soothing cosmetic treatment using such a composition

  本发明涉及3-烷基-(4,5-二苯基-咪唑-1-基)家族的新化合物，其合成方法以及含有它们的化妆品、卫生或药物组合物。本发明还涉及在生理上可接受的介质中使用3-烷基-(4,5-二苯基-咪唑-1-基)家族的至少一个化合物制备舒缓组合物。本发明还涉及在生理上可接受的介质中使用3-烷基-(4,5-二苯基-咪唑-1-基)家族的化合物制备舒缓皮肤问题的组合物，例如敏感皮肤、不适、痒、刺激、红斑、热和/或潮红感，优选敏感和/或易激和/或反应和/或过敏症状的皮肤和/或头皮和/或粘膜。最后，本发明涉及使用这样的组合物进行舒缓化妆治疗。
• Novel compounds of the family of 3-alkyl-(4,5-diphenyl-imidazol-1-yl) and their use as soothing agents
  申请人：——

  公开号：US20040192928A1

  公开（公告）日：2004-09-30

  The invention concerns novel compounds of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), their synthesis method and cosmetic, hygienic or pharmaceutical compositions containing them. The invention also concerns the use, in a physiologically acceptable medium, in or for preparing a soothing composition, of at least a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl). The invention further concerns the use, in a physiologically acceptable medium, in or for producing a composition, of at least a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), the compound or the composition being designed to soothe skin troubles such as sensitive skins, discomfort, gnawing, itching, irritations, red spots, heat and/or flush sensations, advantageously sensitive and/or irritable and/or reactive and/or allergic symptoms of the skin and/or the scalp and/or mucosa. Finally, the invention concerns a soothing cosmetic method using such

  本发明涉及一类新的化合物，即3-烷基-(4,5-二苯基-咪唑-1-基)家族化合物，其合成方法以及含有它们的化妆品、卫生或药物组合物。本发明还涉及在生理上可接受的介质中，使用至少一种3-烷基-(4,5-二苯基-咪唑-1-基)家族化合物制备舒缓组合物的用途。本发明还涉及在生理上可接受的介质中，使用至少一种3-烷基-(4,5-二苯基-咪唑-1-基)家族化合物制备舒缓组合物的用途，该化合物或组合物旨在缓解皮肤问题，例如敏感皮肤、不适、咬痒、刺激、红斑、热感和/或潮红感，尤其是皮肤和/或头皮和/或黏膜的敏感和/或易怒和/或反应和/或过敏症状。最后，本发明涉及使用这种舒缓化妆方法。