3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)aniline | 86556-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)aniline
• 英文别名: 3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]aniline
• CAS: 86556-08-3
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: PUDOJDLATQIMAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)aniline 、 8-(3-(trifluoromethyl)phenyl)quinoline-2-carboxylic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以64%的产率得到N-(3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)-8-(3-(trifluoromethyl)phenyl)quinoline-2-carboxamide
  参考文献：
  名称：

  [EN] 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  [FR] QUINOLÉINES SUBSTITUÉES EN 8 ET ANALOGUES ASSOCIÉS UTILISÉS COMME MODULATEURS DE SIRTUINE

  摘要：

  本文提供了8-取代喹啉和相关类似物作为结构式（I）的抑制素调节化合物以及其使用方法。这些抑制素调节化合物可用于延长细胞寿命，并用于治疗和/或预防各种疾病和紊乱，包括与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症和/或潮红有关的疾病或紊乱，以及那些会受益于增加线粒体活性的疾病或紊乱。还提供了包含抑制素调节化合物与另一治疗剂结合的组合物。

  公开号：

  WO2010101949A1
• 作为产物：
  描述：

  2,2-dimethyl-4-((3-nitrophenoxy)methyl)-1,3-dioxolane 在 铁粉 氯化铵 作用下， 以 水 、 异丙醇 为溶剂， 反应 18.0h， 以79%的产率得到3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)aniline
  参考文献：
  名称：

  [EN] 3-SUBSTITUED IMIDAZO (4, 5-B) PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS
  [FR] PYRIDINES IMIDAZO (4, 5-B) 3-SUBSTITUÉES ET ANALOGUES UTILISÉS COMME MODULATEURS DE SIRTUINES

  摘要：

  本文提供了一种新型调节sirtuin的化合物及其使用方法。这些调节sirtuin的化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和紊乱，包括与老化或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症和/或潮红相关的疾病或紊乱，以及那些受益于增加线粒体活性的疾病或紊乱。还提供了含有sirtuin调节化合物与另一治疗剂结合的组合物。

  公开号：

  WO2011116176A1

文献信息

• [EN] BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] BENZIMIDAZOLES ET ANALOGUES ASSOCIÉS EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2010003048A1

  公开（公告）日：2010-01-07

  Provided herein are sirtuin-modulating compounds of formula (II) The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了公式（II）的调节sirtuin的化合物。这些调节sirtuin的化合物可用于延长细胞的寿命，并用于治疗和/或预防各种疾病和紊乱，包括与衰老或压力有关的疾病或紊乱、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症、潮红以及那些会受益于增加线粒体活性的疾病或紊乱。还提供了包含调节sirtuin化合物与另一治疗剂结合的组合物。
• [EN] IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] IMIDAZOPYRIDINE ET ANALOGUES LIÉS EN TANT QUE MODULATEURS DE LA SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009146358A1

  公开（公告）日：2009-12-03

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新颖的调节sirtuin的化合物及其使用方法。这些调节sirtuin的化合物可用于增加细胞的寿命，并用于治疗和/或预防各种疾病和紊乱，包括与老化或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症、潮红以及需要增加线粒体活性的疾病或紊乱相关的疾病或紊乱。还提供了包含sirtuin调节化合物与另一种治疗剂组合的组合物。
• IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Vu Chi B.

  公开号：US20110077248A1

  公开（公告）日：2011-03-31

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了一种新的调节sirtuin的化合物及其使用方法。这些调节sirtuin的化合物可用于增加细胞寿命，治疗和/或预防各种疾病和障碍，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块障碍、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或障碍。还提供了含有调节sirtuin的化合物和另一种治疗剂的组合物。
• QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Vu Chi B.

  公开号：US20110306612A1

  公开（公告）日：2011-12-15

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新型的sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和障碍，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块疾病、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或障碍。还提供了包含sirtuin调节化合物和另一种治疗剂的组合物。
• BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Vu Chi B

  公开号：US20110124637A1

  公开（公告）日：2011-05-26

  Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders relating to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供的是公式（II）的sirtuin调节化合物。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾患，包括与衰老或压力有关的疾病或疾患、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块疾病、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或疾患。还提供了包含sirtuin调节化合物与另一种治疗剂的组合物。