2-<2-<(Methylsulfonyl)oxy>ethoxy>ethanol | 118591-57-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-<2-<(Methylsulfonyl)oxy>ethoxy>ethanol
• 英文别名: S-(2-hydroxy-ethoxy)-ethyl methanesulfonate；2-(2-hydroxyethoxy)ethyl methanesulfonate；5-hydroxy-3-oxapentyl methanesulphonate；Diethylne glycol monomesylate
• CAS: 118591-57-4
• 化学式: C₅H₁₂O₅S
• 分子量: 184.213
• InChiKey: NENTXTVKVQPSTN-UHFFFAOYSA-N

物化性质

• 沸点：
  369.3±22.0 °C(Predicted)
• 密度：
  1.294±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-<2-<(Methylsulfonyl)oxy>ethoxy>ethanol 在 sodium azide 作用下， 以 乙腈 为溶剂， 生成 2-(2-叠氮乙氧基)乙醇
  参考文献：
  名称：

  A convergent synthesis of heterocyclic dendrimers using the 1,3-dipolar cycloaddition reaction of organic azides and acetylenedicarboxylate esters

  摘要：

  利用有机叠氮化物和乙炔二羧酸酯的 1,3 双极环加成反应，制备了含有 1,2,3 三唑环的树枝状聚合物。

  DOI：

  10.1039/b000025f
• 作为产物：
  描述：

  甲基磺酰氯 、 二乙二醇 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以45%的产率得到2-<2-<(Methylsulfonyl)oxy>ethoxy>ethanol
  参考文献：
  名称：

  设计用于蛋白质二维结晶的类固醇激素衍生物相关的新磷脂的合成

  摘要：

  据报道，合理设计用于孕酮和雌二醇受体的二维结晶的磷脂1 n - 3 n的合成。这些脂质的结构为它们提供了必要的特性，例如当在空气/ H 2 O界面扩散为单层时的流动性和稳定性，对要结晶的蛋白质的亲和力以及脂质单层下配体的可及性。

  DOI：

  10.1002/hlca.19910740810

文献信息

• SULFORAPHANE-DERIVED COMPOUNDS, PRODUCTION METHOD THEREOF AND THE MEDICAL, FOOD AND COSMETIC USE OF SAME
  申请人：Consejo Superior De Investigaciones CientÍficas (CSIC)

  公开号：US20150110863A1

  公开（公告）日：2015-04-23

  The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.

  本发明涉及具有一般式(I)及其光学异构体或对映体形式的新系列化合物，属于硫代异硫氰酸酯衍生物家族。该发明还涉及其生产方法。此发明还涉及该系列化合物的多种医学（药用、顺势疗法和植物疗法）、食品、化妆品和膳食用途，特别是在预防和/或治疗与氧化过程相关的疾病和任何类型的疾病或损伤方面的使用，或者虽然不涉及该过程，但受Nrf2转录因子介导，例如癌症。这些化合物可以单独使用，或者被包埋在环糊精中。
• New chemical tools for investigating human mitotic kinesin Eg5
  作者：Emmanuel Klein、Salvatore DeBonis、Bernd Thiede、Dimitrios A. Skoufias、Frank Kozielski、Luc Lebeau

  DOI：10.1016/j.bmc.2007.06.016

  日期：2007.10

  We have designed and synthesized a series of monastrol derivatives, an allosteric inhibitor of Eg5, a motor protein responsible for the formation and maintenance of the bipolar spindle in mitotic cells. Sterically demanding structural modifications have been introduced on the skeleton of the parent drug either via a multicomponent Biginelli reaction or a stepwise modification of monastrol. The ability of these compounds to inhibit Eg5 activity has been investigated using two in vitro steady-state ATPase assays (basal and microtubule-stimulated) as well as a cell-based assay. One compound in the series appeared more potent than monastrol by a fivefold factor. Three other compounds that were unable to inhibit Eg5 ATPase activity in vitro proved potent Eg5 inhibitors in the cell-based assay. The results obtained led to the identification of structure-activity relationships further used to design an affinity matrix that can be used for fast and efficient purification of Eg5 from crude lysate of eukaryotic cells. (C) 2007 Elsevier Ltd. All rights reserved.
• [EN] DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5- AMINE<br/>[FR] DÉRIVÉS DE 6- (2,3-DICHLOROPHÉNYL) -1,2,4-TRIAZIN -5-AMINE
  申请人：NEKTAR THERAPEUTICS INDIA PVT LTD

  公开号：WO2015092819A3

  公开（公告）日：2015-11-12
• WO2007/2540
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis of New Phospholipids Linked to Steroid-Hormone Derivatives Designed for Two-Dimensional Crystallization of Proteins
  作者：Luc Lebeau、Pierre Oudet、Charles Mioskowski

  DOI：10.1002/hlca.19910740810

  日期：1991.12.11

  The synthesis of phospholipids 1n–3n, rationally designed for two-dimensional crystallization of progesterone and estradiol receptors, is reported. The structure of these lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H2O interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer

  据报道，合理设计用于孕酮和雌二醇受体的二维结晶的磷脂1 n - 3 n的合成。这些脂质的结构为它们提供了必要的特性，例如当在空气/ H 2 O界面扩散为单层时的流动性和稳定性，对要结晶的蛋白质的亲和力以及脂质单层下配体的可及性。