N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine | 438226-84-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine
• 英文别名: 1-[4-(oxan-2-yloxy)phenyl]-N-trimethylsilylmethanimine
• CAS: 438226-84-7
• 化学式: C₁₅H₂₃NO₂Si
• 分子量: 277.439
• InChiKey: KLTJWUOJQCSTAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine 在 正丁基锂 、 4-甲基苯磺酸吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 异丙醇 为溶剂， 反应 23.0h， 生成 4-[(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-(5-nitro-pyridin-2-ylamino)-methyl]-phenol
  参考文献：
  名称：

  Liposomes from Novel Photolabile Phospholipids:  Light-Induced Unloading of Small Molecules As Monitored by PFG NMR

  摘要：

  A molecular dithiane-based approach to synthesis of novel photolabile phospholipids is developed. These lipids are used in formulations with egg-POPC and cholesterol to prepare light-sensitive liposomes. Irradiation of such liposomes in PBS buffer (medium pressure mercury lamp, Pyrex filter, lambda > 300 nm) significantly increases the bilayer permeability and accelerates the release of entrapped small organic molecules by an order of magnitude. A simple assay, based on (1)H or (19)F PFG NMR measurements of diffusion coefficients, is developed to monitor light-induced unloading of the probe molecules.

  DOI：

  10.1021/ja016874i
• 作为产物：
  描述：

  4-(四氢-吡喃-2-基氧基)-苯甲醛 、 六甲基二硅氮烷 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine
  参考文献：
  名称：

  Liposomes from Novel Photolabile Phospholipids:  Light-Induced Unloading of Small Molecules As Monitored by PFG NMR

  摘要：

  A molecular dithiane-based approach to synthesis of novel photolabile phospholipids is developed. These lipids are used in formulations with egg-POPC and cholesterol to prepare light-sensitive liposomes. Irradiation of such liposomes in PBS buffer (medium pressure mercury lamp, Pyrex filter, lambda > 300 nm) significantly increases the bilayer permeability and accelerates the release of entrapped small organic molecules by an order of magnitude. A simple assay, based on (1)H or (19)F PFG NMR measurements of diffusion coefficients, is developed to monitor light-induced unloading of the probe molecules.

  DOI：

  10.1021/ja016874i