(3-benzyloxy-4-methoxybenzyl)triphenylphosphonium chloride | 51458-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-benzyloxy-4-methoxybenzyl)triphenylphosphonium chloride
• 英文别名: {[3-(Benzyloxy)-4-methoxyphenyl]methyl}(triphenyl)phosphanium chloride；(4-methoxy-3-phenylmethoxyphenyl)methyl-triphenylphosphanium;chloride
• CAS: 51458-25-4
• 化学式: C₃₃H₃₀O₂P*Cl
• 分子量: 525.027
• InChiKey: CBALSFATPVHGTL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.77
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  (3-benzyloxy-4-methoxybenzyl)triphenylphosphonium chloride 在 palladium on activated charcoal 、 potassium tert-butylate 、 氢气 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 11.25h， 生成 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl 2-(2,2-dichloroacetamido)acetate
  参考文献：
  名称：

  二氯乙酸偶联二苯乙烷类化合物、其制备方法和应用

  摘要：

  本发明属于药物合成技术领域，尤其是涉及二氯乙酸偶联二苯乙烷类化合物及其制备方法和应用。本发明的二氯乙酸偶联二苯乙烷类化合物结构如通式(I)所示，其中R1、R2和R3分别选自但不限于‑OH、‑OMe、H中的任意一种，R4选自但不限于‑OMe、‑OEt中的任意一种，R5和R6选自氯原子或氟原子，m为0或者1，n选自1‑8或者11‑12中的正整数。本发明的二氯乙酸偶联二苯乙烷类化合物结构稳定、毒性低，制备工艺简便、收率高，并且不需要避光保存，对多种体外培养的肿瘤细胞均有明显的抗肿瘤活性，体内抗肿瘤效果显著。通式(I)为：

  公开号：

  CN114230466A
• 作为产物：
  描述：

  4-(氯甲基)-1-甲氧基-2-苯基甲氧基苯 、 三苯基膦 以 甲苯 为溶剂， 反应 24.0h， 以74%的产率得到(3-benzyloxy-4-methoxybenzyl)triphenylphosphonium chloride
  参考文献：
  名称：

  Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives

  摘要：

  The synthesis of new acridinone and dioxophenothiazine derivatives along with their tubulin polymerization inhibitory and antiproliferative activities is reported. The analysis of correlation for cytotoxic and antitubulin potential of tested compounds showed that 4-methoxyphenylethyl derivatives 18a and 19a were highly cytotoxic but were regarded to have no significant antitubulin activity. However, the introduction of a 3-hydroxy substituent leading to compounds 18e and 19e, strongly increased the antitubulin potential but was associated with a loss of the antiproliferative activity. Modeling studies, topoisomerase inhibition assays and cell cycle analysis have been performed to better investigate the mechanism of action of such compounds. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.10.051

文献信息

• ANTIMICROBIAL SOLUTION COMPRISING A METALLIC SALT AND A SURFACTANT
  申请人：CTT GROUP INC.

  公开号：EP1976388A1

  公开（公告）日：2008-10-08
• Antimicrobial Solution Comprising a Metallic Salt and a Surfactant
  申请人：Tessier Dominic

  公开号：US20080199502A1

  公开（公告）日：2008-08-21

  The present invention concerns solutions having an antimicrobial activity. The solutions described herein comprise particles containing slightly soluble metallic salt and surfactant. In the solutions described herein, the molar ratio between the slightly soluble metallic salt and the surfactant is lower than or equal to about 1. Also described are substrates comprising the solutions, methods for producing substrate comprising the solutions, methods for producing the solutions and uses of the solutions for substrate finishing and substrate sanitization.
• NEW ANTIMICROBIAL COMPOSITIONS AND USES THEREOF
  申请人：CTT Group Inc.

  公开号：US20150201622A1

  公开（公告）日：2015-07-23

  The present invention concerns solutions having an antimicrobial activity. The solutions described herein comprise particles containing slightly soluble metallic salt and surfactant. In the solutions described herein, the molar ratio between the slightly soluble metallic salt and the surfactant is lower than or equal to about 1. Also described are substrates comprising the solutions, methods for producing substrate comprising the solutions, methods for producing the solutions and uses of the solutions for substrate finishing and substrate sanitization.
• [EN] ANTIMICROBIAL SOLUTION COMPRISING A METALLIC SALT AND A SURFACTANT<br/>[FR] SOLUTION ANTIMICROBIENNE COMPRENANT UN SEL MÉTALLIQUE ET UN TENSIOACTIF
  申请人：CTT GROUP INC

  公开号：WO2006105669A1

  公开（公告）日：2006-10-12

  [EN] The present invention concerns solutions having an antimicrobial activity. The solutions described herein comprise particles containing slightly soluble metallic salt and surfactant. In the solutions described herein, the molar ratio between the slightly soluble metallic salt and the surfactant is lower than or equal to about 1. Also described are substrates comprising the solutions, methods for producing substrate comprising the solutions, methods for producing the solutions and uses of the solutions for substrate finishing and substrate sanitization.
  [FR] La présente invention concerne des solutions présentant une activité antimicrobienne. Les solutions décrites dans la présente invention comprennent des particules contenant un sel métallique légèrement soluble ainsi qu'un tensioactif. Dans les solutions décrites dans la présente invention, le rapport molaire entre le sel métallique légèrement soluble et le tensioactif est inférieur ou égal à environ 1. La présente invention décrit en outre des substrats comprenant lesdites solutions, des méthodes de production de substrats comprenant lesdites solutions, des méthodes de production desdites solutions ainsi que des applications desdites solutions en finition de substrats et en désinfection de substrats.