1-n-Octyl-3,6-dioxa-1,8-octanediol | 112371-12-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-n-Octyl-3,6-dioxa-1,8-octanediol
• 英文别名: 1-[2-(2-Hydroxyethoxy)ethoxy]decan-2-ol
• CAS: 112371-12-7
• 化学式: C₁₄H₃₀O₄
• 分子量: 262.39
• InChiKey: ONSSONFMUIJOPS-UHFFFAOYSA-N

物化性质

• 沸点：
  381.3±22.0 °C(Predicted)
• 密度：
  0.980±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-n-Octyl-3,6-dioxa-1,8-octanediol 在 氯化亚砜 作用下， 反应 18.0h， 生成 Dimethyl 4-n-Octyl-3,6,9,12-tetraoxatetradecanedioate
  参考文献：
  名称：

  Bradshaw, Jerald S.; Huszthy, Peter; Izatt, Reed M., Journal of Heterocyclic Chemistry, 1986, vol. 23, # 6, p. 1673 - 1676

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-二甲基丁炔酯 、 二乙二醇 在 sodium 作用下， 反应 72.0h， 以78%的产率得到1-n-Octyl-3,6-dioxa-1,8-octanediol
  参考文献：
  名称：

  Bradshaw, Jerald S.; Huszthy, Peter; Izatt, Reed M., Journal of Heterocyclic Chemistry, 1986, vol. 23, # 6, p. 1673 - 1676

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING CYCLIC ESTER
  申请人：Kureha Corporation

  公开号：US20200392102A1

  公开（公告）日：2020-12-17

  In a method for producing a cyclic ester according to an embodiment of the present invention, a mixture (I) containing an aliphatic polyester, a specific polyalkylene glycol diether, and a sulfonic acid compound as a thermal stabilizer is prepared and heated in predetermined conditions to obtain a mixture (II) in a state of solution. Furthermore, heating of the mixture (II) is continued to distill, together with the polyalkylene glycol diether, a cyclic ester formed by the depolymerization reaction, and thus a distillate (III) is obtained. The cyclic ester is recovered from the distillate (III). At this time, a specific solubilizing agent is added to at least one of the mixture (I) or (II). In this production method, the sulfonic acid compound as the thermal stabilizer is contained in the mixtures (I) and (II) and the distillate (III).

  根据本发明实施例的一种制备环酯的方法中，制备含有脂肪族聚酯、特定聚烷基醚二醇和磺酸化合物作为热稳定剂的混合物(I)，并在预定条件下加热，得到处于溶液状态的混合物(II)。此外，继续加热混合物(II)以蒸馏，与聚烷基醚二醇一起蒸馏出由去聚合反应形成的环酯，从而得到馏出物(III)。从馏出物(III)中回收环酯。此时，在混合物(I)或(II)中至少添加一种特定的溶解剂。在此生产方法中，磺酸化合物作为热稳定剂被包含在混合物(I)、(II)和馏出物(III)中。
• METHOD FOR PRODUCING GLYCOLIDE
  申请人：Kureha Corporation

  公开号：EP2980084A1

  公开（公告）日：2016-02-03

  A method for producing glycolide (GL) by heating a glycolic acid oligomer (GAO) to depolymerize the GAO. The method for producing GL comprises: a step 1 of heating a mixture containing a GAO having a terminal COOH concentration of 400 eq/t or less and a polar organic solvent to a GAO depolymerization temperature under ambient pressure or reduced pressure; a step 2 of continuing the heating at the temperature for depolymerizing of the GAO and then codistilling out the produced GL and the solvent from the depolymerization reaction system to the outside the reaction system; and a step 3 of obtaining GL from the codistillation product. In the method for producing GL, the GAO is preferably prepared by a GAO production method which comprises a step of condensing glycolic acid (GA) and a dehydration step of continuing the heating together with a polar organic solvent or a depolymerization reaction solution to allow the GA condensation reaction to continue.

  一种通过加热乙醇酸低聚物（GAO）使其解聚来生产乙二醇化物（GL）的方法。生产 GL 的方法包括：步骤 1：在环境压力或减压条件下，将含有末端 COOH 浓度为 400 eq/t 或更低的 GAO 和极性有机溶剂的混合物加热到 GAO 解聚温度；步骤 2：在 GAO 解聚温度下继续加热，然后将生成的 GL 和溶剂从解聚反应系统中分馏到反应系统之外；以及步骤 3：从分馏产物中获得 GL。在生产 GL 的方法中，优选使用 GAO 生产方法制备 GAO，该方法包括缩合乙醇酸 （GA）的步骤，以及与极性有机溶剂或解聚反应溶液一起继续加热以允许 GA 缩合反 应继续进行的脱水步骤。
• GLYCOLIDE PRODUCTION METHOD
  申请人：Kureha Corporation

  公开号：EP3770154A1

  公开（公告）日：2021-01-27

  The object of the present invention is to provide a glycolide production method capable of sufficiently increasing the production rate of glycolide. The glycolide production method according to the present invention includes: adding metal titanium to an aqueous glycolic acid solution; subjecting glycolic acid contained in the aqueous glycolic acid solution to which the metal titanium is added, to dehydrating polycondensation to obtain a glycolic acid oligomer; and heating and depolymerizing the glycolic acid oligomer to obtain glycolide.

  本发明的目的是提供一种能够充分提高乙二酸生产率的乙二酸生产方法。根据本发明的缩水甘油醚生产方法包括：在乙醇酸水溶液中加入金属钛；将加入金属钛的乙醇酸水溶液中所含的乙醇酸进行脱水缩聚，以获得乙醇酸低聚物；加热并解聚乙醇酸低聚物，以获得缩水甘油醚。
• Glycolide production method
  申请人：Kureha Corporation

  公开号：US11001565B2

  公开（公告）日：2021-05-11

  The object of the present invention is to provide a glycolide production method capable of further increasing the production rate of glycolide. The glycolide production method according to the present invention includes adding metal iron to an aqueous glycolic acid solution, subjecting glycolic acid contained in the aqueous glycolic acid solution to which the metal iron is added, to dehydrating polycondensation to obtain a glycolic acid oligomer, and heating and depolymerizing the glycolic acid oligomer to obtain glycolide.

  本发明的目的是提供一种能够进一步提高乙二酸生产率的乙二酸生产方法。根据本发明的缩水甘油醚生产方法，包括在乙醇酸水溶液中加入金属铁，将加入金属铁的乙醇酸水溶液中所含的乙醇酸进行脱水缩聚以获得乙醇酸低聚物，加热并解聚乙醇酸低聚物以获得缩水甘油醚。
• Method for producing cyclic ester
  申请人：Kureha Corporation

  公开号：US11078179B2

  公开（公告）日：2021-08-03

  In a method for producing a cyclic ester according to an embodiment of the present invention, a mixture (I) containing an aliphatic polyester, a specific polyalkylene glycol diether, and a sulfonic acid compound as a thermal stabilizer is prepared and heated in predetermined conditions to obtain a mixture (II) in a state of solution. Furthermore, heating of the mixture (II) is continued to distill, together with the polyalkylene glycol diether, a cyclic ester formed by the depolymerization reaction, and thus a distillate (III) is obtained. The cyclic ester is recovered from the distillate (III). At this time, a specific solubilizing agent is added to at least one of the mixture (I) or (II). In this production method, the sulfonic acid compound as the thermal stabilizer is contained in the mixtures (I) and (II) and the distillate (III).

  根据本发明的一个实施例，在生产环酯的方法中，制备含有脂肪族聚酯、特定的聚 烃二醇二醚和作为热稳定剂的磺酸化合物的混合物（I），并在预定条件下加热，得到溶液状 态的混合物（II）。此外，继续加热混合物 (II)，与聚烷基二醇二醚一起蒸馏由解聚反应形成的环酯，从而得到蒸馏物 (III)。从馏分（III）中回收环酯。此时，在混合物（I）或（II）中的至少一种中加入特定的增溶剂。在这种生产方法中，作为热稳定剂的磺酸化合物包含在混合物（I）和（II）以及蒸馏物（III）中。