3-methoxy-7,8-dimethyl-11H-isoindolo[2,1-a]benzimidazole | 1571902-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 3-methoxy-7,8-dimethyl-11H-isoindolo[2,1-a]benzimidazole
• CAS: 1571902-26-5
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: SQBYMGIKOZZXTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(4-methoxybenzyl)(5,6-dimethyl)benzimidazole 在 palladium diacetate 、 copper (I) acetate 、 copper(II) acetate monohydrate 、 cesium pivalate 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以63%的产率得到3-methoxy-7,8-dimethyl-11H-isoindolo[2,1-a]benzimidazole
  参考文献：
  名称：

  Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling

  摘要：

  Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.103

文献信息

• Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling
  作者：Kyle C. Pereira、Ashley L. Porter、Brenton DeBoef

  DOI：10.1016/j.tetlet.2014.01.103

  日期：2014.3

  Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif. (C) 2014 Elsevier Ltd. All rights reserved.