2-环己烯-1-酮,3-甲基-5-(1-甲基乙烯基)-,(5R)- | 179605-47-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-环己烯-1-酮,3-甲基-5-(1-甲基乙烯基)-,(5R)-
• 中文别名: (3-氨基-2-氧代-1-吡咯烷基)乙酸
• 英文名称: [(3R)-3-Amino-2-oxopyrrolidin-1-yl]acetic acid
• 英文别名: 2-[(3R)-3-amino-2-oxopyrrolidin-1-yl]acetic acid
• CAS: 179605-47-1
• 化学式: C₆H₁₀N₂O₃
• 分子量: 158.16
• InChiKey: ZMCJOKMEFYSAOH-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn
  申请人：Mezo R. Adam

  公开号：US20070254831A1

  公开（公告）日：2007-11-01

  The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
• PEPTIDES THAT BLOCK THE BINDING OF IgG TO FcRn
  申请人：MEZO ADAM R.

  公开号：US20110059889A1

  公开（公告）日：2011-03-10

  The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
• IMMUNOMODULATORY PEPTIDES
  申请人：Mezo Adam R.

  公开号：US20110230639A1

  公开（公告）日：2011-09-22

  The invention relates to peptides derivatized with a hydrophilic polymer which, in some embodiments, bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used in some embodiments, for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates, in further embodiments, to methods of using and methods of making the peptides of the invention.
• US8101186B2
  申请人：——

  公开号：US8101186B2

  公开（公告）日：2012-01-24
• US8906844B2
  申请人：——

  公开号：US8906844B2

  公开（公告）日：2014-12-09