2-环戊基戊酸 | 5732-83-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-环戊基戊酸
• 英文名称: 2-cyclopentyl-valeric acid
• 英文别名: 2-Cyclopentyl-valeriansaeure；2-Cyclopentylvaleriansaeure；2-Cyclopentyl-pentansaeure；2-Cyclopentylvaleric acid；2-cyclopentylpentanoic acid
• CAS: 5732-83-2
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: IDBPUJMARBNOJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-环戊基戊酸 在 氯化亚砜 作用下， 生成 2-cyclopentyl-valeric acid-(2,6-dimethyl-[3]pyridyl ester)
  参考文献：
  名称：

  PARASYMPATHETIC BLOCKING AGENTS. II^{1, 2}

  摘要：

  DOI：

  10.1021/jo01124a010
• 作为产物：
  描述：

  正戊酸 生成 2-环戊基戊酸
  参考文献：
  名称：

  Taillandier; Benoit Guyod; Boucherle, European Journal of Medicinal Chemistry, 1975, vol. 10, # 5, p. 453 - 462

  摘要：

  DOI：

文献信息

• NERVE REGENERATION PROMOTERS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1685832A1

  公开（公告）日：2006-08-02

  A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.

  由式 (I) 所表示的化合物组成的神经再生剂： (其中所有符号均在描述中显示）、其盐或其原药。本发明化合物可抑制神经细胞死亡，可作为加速干细胞（神经干细胞、胚胎干细胞、骨髓细胞等）生长和/或分化的物质、加速神经前体细胞生长和/或分化的物质、神经营养因子活性增效剂、神经营养因子样物质或神经退行性抑制剂，并通过新生、再生和/或轴突演化加速神经组织的修复和再生。此外，本发明的化合物可用于从脑组织、骨髓和/或胚胎干细胞中制备移植细胞（神经干细胞、神经前体细胞、神经细胞等），还可加速移植细胞的移植、生长、分化和/或功能表达，从而可用于预防和/或治疗神经退行性疾病。
• Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
  申请人：Chase Matthew

  公开号：US20050009151A1

  公开（公告）日：2005-01-13

  The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

  本发明涉及β-氨基酸的立体特异性合成和对映体富集方法。从一株新分离出来的藻类中纯化出了一种新型 D-β-氨基转移酶，它对 D-β-苯丙氨酸（D-3 氨基-3-苯丙氨酸）具有立体选择性。 从新分离的 .从一株新分离的藻类中纯化出一种新型 L-β-氨基转移酶。 藻类 .D- 和 L-β- 氨基转移酶可用于促进β-D-苯丙氨酸或β-L-苯丙氨酸的立体选择性生物合成，分别由 L-谷氨酸或 L-丙氨酸与 3-酮基-3-苯基丙酸的混合物在辅助因子磷酸吡哆醛的存在下合成。
• Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles
  作者：Frederick J. Brown、Ying K. Yee、Laura A. Cronk、Kevin C. Hebbel、Robert D. Krell、David W. Snyder

  DOI：10.1021/jm00168a036

  日期：1990.6

  A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes. A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents. The corresponding indazoles were equipotent. These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea.
• Antispasmodics. I. Cyclopentyl and Δ²-Cyclopentenyl Substituted Diethylaminoethyl Esters¹
  作者：Robert Bruce Moffett、Charlotte Anne Hart、Willard M. Hoehn

  DOI：10.1021/ja01200a003

  日期：1947.8
• 4,4'-(2-cycloalkyl-alkylidene) diphenols and ethers and esters thereof
  申请人：PARKE DAVIS + COMPANY

  公开号：US03661976A1

  公开（公告）日：1972-05-09