cyclo[Aoda-Trp(EtO2H)(EtO2H)-Ile-D-Pip] | 321798-87-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclo[Aoda-Trp(EtO2H)(EtO2H)-Ile-D-Pip]
• 英文别名: 2-[3-[[(3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-2,5,8,11-tetraoxo-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecan-6-yl]methyl]indol-1-yl]acetic acid
• CAS: 321798-87-2
• 化学式: C₃₅H₄₉N₅O₇
• 分子量: 651.803
• InChiKey: SOGXSPMNYVWNRR-FTXZBAAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  47
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  167
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  cyclo[Aoda-Trp(EtO2H)(EtO2H)-Ile-D-Pip] 在 臭氧 、 二甲基硫 、 potassium tert-butylate 作用下， 以 二氯甲烷 、 四氢呋喃 、 叔丁醇 为溶剂， 反应 0.17h， 以69%的产率得到{3-[(6S,9S,12S,14aR)-6-((S)-sec-Butyl)-5,8,11,14-tetraoxo-12-(6-oxo-octyl)-tetradecahydro-4a,7,10,13-tetraaza-benzocyclododecen-9-yl]-4-oxo-4H-quinolin-1-yl}-acetic acid
  参考文献：
  名称：

  Synthesis of Apicidin-Derived Quinolone Derivatives:  Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents

  摘要：

  Apicidin's indole was efficiently converted into a series of N-substituted quinolone derivatives by indole N-alkylation followed by a two-step, one-pot, ozonolysis/aldol condensation protocol. The new quinolones exhibited good parasite selectivity and potency both at the level of their molecular target, histone deacetylase, and in their whole cell antiproliferative activity in vitro.

  DOI：

  10.1021/jm0001976
• 作为产物：
  描述：

  {3-[(6S,9S,12S,14aR)-6-((S)-sec-Butyl)-5,8,11,14-tetraoxo-12-(6-oxo-octyl)-tetradecahydro-4a,7,10,13-tetraaza-benzocyclododecen-9-ylmethyl]-indol-1-yl}-acetic acid methyl ester 在 lithium hydroxide 作用下， 生成 cyclo[Aoda-Trp(EtO2H)(EtO2H)-Ile-D-Pip]
  参考文献：
  名称：

  Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

  摘要：

  It has been widely debated whether class IIa HDACs have catalytic deacetylase activity, and whether this plays any part in controlling gene expression. Herein, it has been demonstrated that class IIa HDACs isolated from mammalian cells are contaminated with other deacetylases, but can be prepared cleanly in Escherichia coli. These bacteria preparations have weak but measurable deacetylase activity. The low efficiency can be restored either by: mutation of an active site histidine to tyrosine, or by the use of a non-acetylated lysine substrate, allowing the development of assays to identify class IIa HDAC inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.025

文献信息

• Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases
  作者：Philip Jones、Sergio Altamura、Raffaele De Francesco、Paola Gallinari、Armin Lahm、Petra Neddermann、Michael Rowley、Sergio Serafini、Christian Steinkühler

  DOI：10.1016/j.bmcl.2008.02.025

  日期：2008.3

  It has been widely debated whether class IIa HDACs have catalytic deacetylase activity, and whether this plays any part in controlling gene expression. Herein, it has been demonstrated that class IIa HDACs isolated from mammalian cells are contaminated with other deacetylases, but can be prepared cleanly in Escherichia coli. These bacteria preparations have weak but measurable deacetylase activity. The low efficiency can be restored either by: mutation of an active site histidine to tyrosine, or by the use of a non-acetylated lysine substrate, allowing the development of assays to identify class IIa HDAC inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.
• Synthesis of Apicidin-Derived Quinolone Derivatives:  Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents
  作者：Peter T. Meinke、Steven L. Colletti、George Doss、Robert W. Myers、Anne M. Gurnett、Paula M. Dulski、Sandra J. Darkin-Rattray、John J. Allocco、Stefan Galuska、Dennis M. Schmatz、Matthew J. Wyvratt、Michael H. Fisher

  DOI：10.1021/jm0001976

  日期：2000.12.1

  Apicidin's indole was efficiently converted into a series of N-substituted quinolone derivatives by indole N-alkylation followed by a two-step, one-pot, ozonolysis/aldol condensation protocol. The new quinolones exhibited good parasite selectivity and potency both at the level of their molecular target, histone deacetylase, and in their whole cell antiproliferative activity in vitro.