des-A,B-18-[2-(methoxycarbonyl)ethyl]-20-methylpregn-20-en-8-one | 442200-73-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: des-A,B-18-[2-(methoxycarbonyl)ethyl]-20-methylpregn-20-en-8-one
• 英文别名: methyl 4-[(3R,3aS,7aR)-7-oxo-3-prop-1-en-2-yl-2,3,4,5,6,7a-hexahydro-1H-inden-3a-yl]butanoate
• CAS: 442200-73-9
• 化学式: C₁₇H₂₆O₃
• 分子量: 278.392
• InChiKey: FAANOFAUYSVKQQ-KEYYUXOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  des-A,B-18-[2-(methoxycarbonyl)ethyl]-20-methylpregn-20-en-8-one 在 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 23.0h， 生成 (5Z,7E)-(1S,3R)-18-(3-hydroxy-3-methylbutyl)-20-methyl-9,10-secopregna-5,7,10(19),20-tetraene-1,3-diol
  参考文献：
  名称：

  Synthesis of New 18-Substituted Analogues of Calcitriol Using a Photochemical Remote Functionalization

  摘要：

  A novel convergent synthetic approach to new analogues of calcitriol modified at the C-18 position is reported. The key step in the synthesis is the 20-hydroxyl-directed photochemical iodination of the 18-methyl group in the presence of (diacetoxyiodo)benzene. Using this methodology, two new analogues of calcitriol were prepared: the first contains a hydroxylated alkyl side chain attached at C-18 with the natural side chain replaced by an isopropylidene group; the second is a conformationally locked analogue due to an extra oxacycle between the C-18 and C-20 positions.

  DOI：

  10.1021/jo020022z
• 作为产物：
  描述：

  (8β)-des-A,B-18-[2-(methoxycarbonyl)ethyl]-20-methylpregn-20-en-8-ol 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以88%的产率得到des-A,B-18-[2-(methoxycarbonyl)ethyl]-20-methylpregn-20-en-8-one
  参考文献：
  名称：

  Synthesis of New 18-Substituted Analogues of Calcitriol Using a Photochemical Remote Functionalization

  摘要：

  A novel convergent synthetic approach to new analogues of calcitriol modified at the C-18 position is reported. The key step in the synthesis is the 20-hydroxyl-directed photochemical iodination of the 18-methyl group in the presence of (diacetoxyiodo)benzene. Using this methodology, two new analogues of calcitriol were prepared: the first contains a hydroxylated alkyl side chain attached at C-18 with the natural side chain replaced by an isopropylidene group; the second is a conformationally locked analogue due to an extra oxacycle between the C-18 and C-20 positions.

  DOI：

  10.1021/jo020022z

文献信息

• Synthesis of New 18-Substituted Analogues of Calcitriol Using a Photochemical Remote Functionalization
  作者：Iván Cornella、José Pérez Sestelo、Antonio Mouriño、Luis A. Sarandeses

  DOI：10.1021/jo020022z

  日期：2002.7.1

  A novel convergent synthetic approach to new analogues of calcitriol modified at the C-18 position is reported. The key step in the synthesis is the 20-hydroxyl-directed photochemical iodination of the 18-methyl group in the presence of (diacetoxyiodo)benzene. Using this methodology, two new analogues of calcitriol were prepared: the first contains a hydroxylated alkyl side chain attached at C-18 with the natural side chain replaced by an isopropylidene group; the second is a conformationally locked analogue due to an extra oxacycle between the C-18 and C-20 positions.