[[2-(Phenylmethoxycarbonylamino)acetyl]amino]methylphosphonic acid | 136967-26-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [[2-(Phenylmethoxycarbonylamino)acetyl]amino]methylphosphonic acid
• CAS: 136967-26-5
• 化学式: C₁₁H₁₅N₂O₆P
• 分子量: 302.224
• InChiKey: SSNZNTVQANNDAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [[2-(Phenylmethoxycarbonylamino)acetyl]amino]methylphosphonic acid 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 以67%的产率得到glycyl-aminomethylenephosphonic acid
  参考文献：
  名称：

  Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group

  摘要：

  Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.

  DOI：

  10.1080/00397919108021063
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 1.5h， 生成 [[2-(Phenylmethoxycarbonylamino)acetyl]amino]methylphosphonic acid
  参考文献：
  名称：

  Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group

  摘要：

  Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.

  DOI：

  10.1080/00397919108021063

文献信息

• Kukhar, Valery; Solodenko, Vladimir; Soloshonok, Vadim, Phosphorus, Sulfur and Silicon and the Related Elements, 1996, vol. 109, # 1-4, p. 529 - 532
  作者：Kukhar, Valery、Solodenko, Vladimir、Soloshonok, Vadim、Kasheva, Tamara

  DOI：——

  日期：——
• Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group
  作者：Vladimir Solodenko、Tamara Kasheva、Valeri Kukhar

  DOI：10.1080/00397919108021063

  日期：1991.8

  Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.