(2R,3R)-Bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl dichloride | 4582-21-2

• 物质功能分类: 化学试剂 - 有机试剂 - 酰卤
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: (2R,3R)-Bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl dichloride
• 英文别名: trans-Bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl dichloride；(2R,3R)-bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl chloride
• CAS: 4582-21-2
• 化学式: C₉H₈Cl₂O₂
• 分子量: 219.067
• InChiKey: KANQIAARVSWKKG-TVVDDFTJSA-N

物化性质

• 沸点：
  114-118 °C/11 mmHg (lit.)
• 密度：
  1.349 g/mL at 25 °C (lit.)
• 闪点：
  >230 °F

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  8
• 危险品标志：
  C
• 安全说明：
  S23,S24/25,S26,S28,S36/37/39,S45
• 危险类别码：
  R34
• WGK Germany：
  3
• 海关编码：
  2917209090
• 危险品运输编号：
  UN 3265 8/PG 2
• 包装等级：
  III
• 危险标志：
  GHS05,GHS07
• 危险性描述：
  H312 + H332,H314
• 危险性防范说明：
  P280,P305 + P351 + P338,P310

反应信息

• 作为反应物：
  描述：

  desformyldistamycin A 、 (2R,3R)-Bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl dichloride 以 四氢呋喃 为溶剂， 以53%的产率得到
  参考文献：
  名称：

  Anti-HIV-I activity of linked lexitropsins

  摘要：

  Five groups of lexitropsin oligopeptides have been synthesized that are structurally related to the natural antiviral agents netropsin and distamycin and bearing two such moieties joined by flexible or rigid linkers. Inhibitory activity of these types of agents against murine leukemia retrovirus (MuLV) led to an evaluation of their inhibition of HIV-I in cell culture. The antiretroviral activity of the five different classes of lexitropsins is discussed in terms of their structural differences.

  DOI：

  10.1021/jm00093a023

文献信息

• 1H-imidazo dimers
  申请人：Griesgraber W. George

  公开号：US20050026947A1

  公开（公告）日：2005-02-03

  1H-imidazo dimer compounds are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

  1H-咪唑二聚体化合物可用作免疫反应调节剂。该发明的化合物和组合物能够诱导各种细胞因子的生物合成，可用于治疗包括病毒性疾病和肿瘤性疾病在内的多种疾病。
• Cycloalkene terminated polyarylene ether and polyarylene ether polyalkenamer block copolymers made therefrom
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0467115A1

  公开（公告）日：1992-01-22

  Polyarylene ether-polyalkenamer copolymers are provided by effecting a ring-opening metathesis polymerization (ROMP) of a cycloalkene such as, cyclooctene in the presence of a polyarylene ether having an ester link cycloalkenyl group. An effective amount of a metallic catalyst, such as an osmium or a ruthenium halide, can be used to catalyze the metathesis.

  在具有酯链环烯基的聚芳基醚存在下，通过环烯烃（如环辛烯）的开环偏聚聚合反应（ROMP），可提供聚芳基醚-聚烯酰胺共聚物。有效量的金属催化剂，如锇或卤化钌，可用于催化该偏析反应。
• Plasticized PVC admixtures with surface modifying macromolecules and articles made therefrom
  申请人：Evonik Canada Inc.

  公开号：US10557030B2

  公开（公告）日：2020-02-11

  The present invention relates to polyvinvyl chloride (PVC) admixtures with plasticizers and surface modifying macromolecules. In accordance with embodiments, articles formed from the compositions disclosed herein may reduce leaching of plasticizers.

  本发明涉及含有增塑剂和表面改性大分子的聚氯乙烯（PVC）外加剂。根据本发明的实施方案，用本发明公开的组合物制成的物品可减少增塑剂的沥滤。
• Ester-linked surface modifying macromolecules
  申请人：Evonik Canada Inc.

  公开号：US10975197B2

  公开（公告）日：2021-04-13

  The invention relates to ester-linked surface-modifying macromolecules and admixtures thereof as shown below by the representative compounds. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules).

  本发明涉及酯连接表面改性大分子及其混合物，如下文代表性化合物所示。这些混合物可用于需要增强表面特性（例如，表面特性可减少或防止生物污染、固定生物分子或使某些生物分子变性）的工业和医疗应用中。
• Polymeric organic coatings and method of manufacture thereof
  申请人：——

  公开号：US20010038925A1

  公开（公告）日：2001-11-08

  Polymeric organic coating for electroluminescent lamp components, particularly for phosphor particles and electrodes and a method of making same, wherein the polymer is formed using an initiator, preferably by ring-opening metathesis polymerization. A dense hydrophobic organic coating is formed which is capable of protecting the electroluminescent device components from exogenous agents such as moisture and eventual degradation. The polymer layer may be attached to an outer surface of the component by one or more tethering layers.

  用于电致发光灯元件，特别是用于荧光粉颗粒和电极的聚合物有机涂层及其制造方法，其中聚合物是使用引发剂，最好是通过开环偏聚聚合反应形成的。形成的致密疏水性有机涂层能够保护电致发光器件元件不受外源物质（如湿气）的影响，并防止最终降解。聚合物层可通过一个或多个系留层附着在元件的外表面。