1,4-Anhydro-2-deoxy-D-erythro-pentitol 5-(Trifluoromethanesulfonate) | 161857-07-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1,4-Anhydro-2-deoxy-D-erythro-pentitol 5-(Trifluoromethanesulfonate)
• 英文别名: [(2R,3S)-3-hydroxyoxolan-2-yl]methyl trifluoromethanesulfonate
• CAS: 161857-07-4
• 化学式: C₆H₉F₃O₅S
• 分子量: 250.196
• InChiKey: RFHIIAJADAAWIV-CRCLSJGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,4-Anhydro-2-deoxy-D-erythro-pentitol 5-(Trifluoromethanesulfonate) 在 nBuNN₃ 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到1,4-Anhydro-5-azido-2,5-dideoxy-D-erythro-pentitol
  参考文献：
  名称：

  Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

  摘要：

  A series of twelve highly active aminomethyl-THF 1 beta-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00282-5
• 作为产物：
  描述：

  1,2-二脱氧-D-核糖 、 三氟甲磺酸酐 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 1,4-Anhydro-2-deoxy-D-erythro-pentitol 5-(Trifluoromethanesulfonate)
  参考文献：
  名称：

  Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems II

  摘要：

  Two series of active aminomethyl-THF 1 beta-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10143-3

文献信息

• 2-thiosubstituted carbapenems
  申请人：American Cyanamid Company

  公开号：US05602118A1

  公开（公告）日：1997-02-11

  Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.

  通式为：##STR1## 的头孢菌素类抗生素化合物，其中基团##STR2## 是一个含有单个、双重或三重取代的氧或硫的4、5或6环；其中Z为氧、硫、亚砜和磺酰基，其制备过程中有用于治疗细菌感染的药物组成物，制备化合物的过程以及在过程中有用的新中间体。
• Method for producing tetrahydrofuranyl compounds
  申请人：——

  公开号：US05623081A1

  公开（公告）日：1997-04-22

  Tetrahydrofuanyl compounds of the following formulae: ##STR1## are disclosed.

  披露了以下式子的四氢呋喃基化合物：##STR1##。
• Method of inhibiting a .beta.-lactamase enzyme by administering novel
  申请人：American Cyanamid Company

  公开号：US05744465A1

  公开（公告）日：1998-04-28

  Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, method of inhibiting a Beta-lactamase enzyme by administering said compounds, processes for preparing the compounds and new intermediates useful in the process are disclosed.

  本发明涉及一般式为##STR1##的碳青霉烯类抗生素化合物，其中基团##STR2##是4、5或6成员的单、二或三取代氧或硫含环；其中Z是氧、硫、亚砜和磺酰基，所述药物组成物对治疗细菌感染有用，通过给予所述化合物抑制β-内酰胺酶酶的方法，揭示了制备该化合物的过程以及在该过程中有用的新中间体。
• Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems II
  作者：Yang-I Lin、Panayota Bitha、Subas M. Sakya、Stanley A. Lang、Youjun Yang、William J. Weiss、Peter J. Petersen、Karen Bush、Raymond T. Testa

  DOI：10.1016/s0960-894x(97)10143-3

  日期：1997.12

  Two series of active aminomethyl-THF 1 beta-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa. (C) 1997 Elsevier Science Ltd.
• US5602118A
  申请人：——

  公开号：US5602118A

  公开（公告）日：1997-02-11