dithiobis(6-hexaneamine) | 45186-02-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: dithiobis(6-hexaneamine)
• 英文别名: 6,6'-disulfanediyldihexan-1-amine；bis-(6-amino-hexyl)-disulfide；Bis-(6-amino-hexyl)-disulfid；Bis-(omega-amino-n-hexyl)-disulfid；6-(6-aminohexyldisulfanyl)hexan-1-amine
• CAS: 45186-02-5
• 化学式: C₁₂H₂₈N₂S₂
• 分子量: 264.5
• InChiKey: ISJROKKGVWIKMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  381.6±27.0 °C(Predicted)
• 密度：
  1.009±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dithiobis(6-hexaneamine) 在 盐酸 、 1,1,2,3-四甲基胍 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 、 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors

  摘要：

  Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of I was significantly reduced by free folic acid, suggesting that cellular uptake of I is mediated by FR. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.040
• 作为产物：
  描述：

  N-(6-羟基己基)氨基甲酸叔丁酯 在 盐酸 、 sodium hydroxide 、 碘 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙酸乙酯 、 丙酮 为溶剂， 生成 dithiobis(6-hexaneamine)
  参考文献：
  名称：

  Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors

  摘要：

  Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of I was significantly reduced by free folic acid, suggesting that cellular uptake of I is mediated by FR. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.040

文献信息

• Microorganism detection and analysis using carbohydrate and lectin recognition
  申请人：Zeng Xiangqun

  公开号：US09366672B2

  公开（公告）日：2016-06-14

  Methods of binding and detecting a microorganism on a solid substrate. The microorganism is bound on a solid substrate covalently bound to a capture agent having a saccharide moiety. A lectin capable of binding to the microorganism and the saccharide moiety of the capture agent is added to the sample to bind the microorganism on the solid substrate. Further provided are biosensor devices, such as a quartz crystal microbalance (QCM) device or a surface plasmon resonance (SPR) device, that incorporate the solid substrate for the detection of microorganisms.

  将微生物绑定在固体基质上的方法。微生物以共价结合到具有糖基团的捕获剂的固体基质上。添加能够与微生物和捕获剂的糖基团结合的凝集素到样品中，以将微生物绑定在固体基质上。还提供了生物传感器设备，如石英晶体微平衡（QCM）设备或表面等离子共振（SPR）设备，这些设备包含用于检测微生物的固体基质。
• SELF ASSEMBLED MOLECULES ON IMMERSION SILVER COATINGS
  申请人：Abys Joseph A.

  公开号：US20120276409A1

  公开（公告）日：2012-11-01

  A method for enhancing the corrosion resistance of an article comprising a silver coating deposited on a solderable copper substrate is provided. The method comprises exposing the copper substrate having the immersion-plated silver coating thereon to an anti-corrosion composition comprising: a) a multi-functional molecule comprising at least one organic functional group that interacts with and protects copper surfaces and at least one organic functional group that interacts with and protects silver surfaces; b) an alcohol; and c) a surfactant.

  本发明提供了一种增强银涂层在可焊接铜基底上耐腐蚀性的方法。该方法包括将浸镀银涂层的铜基底暴露在一种抗腐蚀组合物中，该组合物包括：a)一种多功能分子，其中至少包括一种有机功能基与保护铜表面相互作用并保护铜表面，以及至少包括一种有机功能基与保护银表面相互作用并保护银表面；b)一种醇；和c)一种表面活性剂。
• Dirscherl; Weingarten, Justus Liebigs Annalen der Chemie, 1951, vol. 574, p. 131,139
  作者：Dirscherl、Weingarten

  DOI：——

  日期：——
• Action of hydrogen sulfide on aminoalkanethiosulfuric acids (Bunte salts) to give di-, tri-, and tetrasulfides
  作者：Daniel L. Klayman、David Kenny、Richard B. Silverman、Joseph E. Tomaszewski、Robert J. Shine

  DOI：10.1021/jo00823a005

  日期：1971.12
• Epigenetic profiling of the antitumor natural product psammaplin A and its analogues
  作者：José García、Gianluigi Franci、Raquel Pereira、Rosaria Benedetti、Angela Nebbioso、Fátima Rodríguez-Barrios、Hinrich Gronemeyer、Lucia Altucci、Angel R. de Lera

  DOI：10.1016/j.bmc.2010.12.026

  日期：2011.6

  A collection of analogues of the dimeric natural product psammaplin A that differ in the substitution on the ( halo) tyrosine aryl ring, the oxime and the diamine connection has been synthesized. The effects on cell cycle, induction of differentiation and apoptosis of the natural-product inspired series were measured on the human leukaemia U937 cell line. Epigenetic profiling included induction of p21(WAF1), effects on global H3 histone and tubulin acetylation levels as well as in vitro enzymatic assays using HDAC1, DNMT1, DNMT3A, SIRT1 and a peptide domain with p300/CBP HAT activity. Whereas the derivatives of psammaplin A with modifications in the length of the connecting chain, the oxime bond and the disulfide unit showed lower potency, the analogues with changes on the bromotyrosine ring exhibited activities comparable to those of the parent compound in the inhibition of HDAC1 and in the induction of apoptosis. The lack of HDAC1 activity of analogues modified on the disulfide bond suggests that its cleavage must occur in cells to produce the monomeric Zn2+-chelating thiol. This assumption is consistent with the molecular modelling of the complex of psammaplin A thiol with h-HDAC8. Only a weak inhibition of DNMT1, DNMT3A and residual activities with SIRT1 and a p300/CBP HAT peptide were measured for these compounds. (C) 2010 Elsevier Ltd. All rights reserved.