(3aS)-1-(4-chlorophenoxy)-1-oxido-3a,4-dihydro-3H-[1,3,2]oxazaphospholo[3,4-a]indol-1-ium | 1031238-93-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3aS)-1-(4-chlorophenoxy)-1-oxido-3a,4-dihydro-3H-[1,3,2]oxazaphospholo[3,4-a]indol-1-ium
• CAS: 1031238-93-3
• 化学式: C₁₅H₁₃ClNO₃P
• 分子量: 321.7
• InChiKey: KAKGHKCYHBLHEX-JRTLGTJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (S)-(+)-二氢吲哚-2-甲醇 、 4-氯苯基二氯磷酸酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以63%的产率得到(3aS)-1-(4-chlorophenoxy)-1-oxido-3a,4-dihydro-3H-[1,3,2]oxazaphospholo[3,4-a]indol-1-ium
  参考文献：
  名称：

  Synthesis of Novel (3a,S)‐1‐Aryl/aryloxy/alkoxy‐3a,4‐dihydro‐3H‐1λ⁵‐[1,3,2]oxazaphospholo [3,4‐a] indole‐1‐ones, Thiones, and Selenones

  摘要：

  Synthesis of novel (3a,S)-1-aryl/aryloxy/alkoxy-3a,4-dihydro-3H-1 lambda(5)-[1,3,2]oxazaphospholo [3,4-a] indole-1-ones, thiones, and selenones was achieved in two steps with high yields from 2,3-dihydro-1H-indol-2(S)yl methanol (1) and dichlorophenyl phosphine/ethyl dichlorophosphite (2a and b) in the presence of triethylamine in dry THF followed by treatment with hydrogen peroxide, sulfur, and selenium. The compounds 4g-k have been synthesized by the direct cyclocondensation of 1 with different substituted phenyl phosphorodichloridates (2c-e, g) and bis(2-chloroethyl) phosphoramidic dichloride (2f).

  DOI：

  10.1080/00397910801914236

文献信息

• Synthesis of Novel (3a,S)‐1‐Aryl/aryloxy/alkoxy‐3a,4‐dihydro‐3<i>H</i>‐1λ⁵‐[1,3,2]oxazaphospholo [3,4‐a] indole‐1‐ones, Thiones, and Selenones
  作者：B. Hari Babu、G. Syam Prasad、C. Naga Raju、C. Suresh Reddy

  DOI：10.1080/00397910801914236

  日期：2008.4

  Synthesis of novel (3a,S)-1-aryl/aryloxy/alkoxy-3a,4-dihydro-3H-1 lambda(5)-[1,3,2]oxazaphospholo [3,4-a] indole-1-ones, thiones, and selenones was achieved in two steps with high yields from 2,3-dihydro-1H-indol-2(S)yl methanol (1) and dichlorophenyl phosphine/ethyl dichlorophosphite (2a and b) in the presence of triethylamine in dry THF followed by treatment with hydrogen peroxide, sulfur, and selenium. The compounds 4g-k have been synthesized by the direct cyclocondensation of 1 with different substituted phenyl phosphorodichloridates (2c-e, g) and bis(2-chloroethyl) phosphoramidic dichloride (2f).